Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Manus J. Donahue"'
Autor:
Ahmad A. Toubasi, Jarrod J. Eisma, Jiacheng Wang, Habeeb F. Kazimuddin, Bryan Hernandez, Taegan Vinarsky, Caroline Gheen, Zachary Rohm, Carynn Koch, Margareta A. Clarke, Rachael Cheek, John Kramer, James Eaton, Manus J. Donahue, Francesca Bagnato
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 11, Pp 2912-2922 (2024)
Abstract Objective Paramagnetic rim lesions (PRLs) are a biomarker of chronic active lesions (CALs), and an important driver of neurological disability in multiple sclerosis (MS). The reason subtending some acute lesions evolvement into CALs is not k
Externí odkaz:
https://doaj.org/article/9f56998f082644d2a6ba15a2aaea67eb
Autor:
Melanie Leguizamon, Colin D. McKnight, Tristan Ponzo, Jason Elenberger, Jarrod J. Eisma, Alexander K. Song, Paula Trujillo, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen, Kilian Hett
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Intravenous arachnoid granulations (AGs) are protrusions of the arachnoid membrane into the venous lumen and function as contributors to the cerebrospinal fluid (CSF) flow circuit. Patients with Parkinson disease (PD) often present with accu
Externí odkaz:
https://doaj.org/article/27b4d6ccc982454ca3f3069043e82b4a
Autor:
Gabriela Pierobon Mays, Kilian Hett, Jarrod Eisma, Colin D. McKnight, Jason Elenberger, Alexander K. Song, Ciaran Considine, Wesley T. Richerson, Caleb Han, Adam Stark, Daniel O. Claassen, Manus J. Donahue
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background Parkinson’s disease is characterized by dopamine-responsive symptoms as well as aggregation of α-synuclein protofibrils. New diagnostic methods assess α-synuclein aggregation characteristics from cerebrospinal fluid (CSF) and
Externí odkaz:
https://doaj.org/article/c3db04b28b15466ba8491545ab2c8ce4
Autor:
Kilian Hett, Colin D. McKnight, Melanie Leguizamon, Jennifer S. Lindsey, Jarrod J. Eisma, Jason Elenberger, Adam J. Stark, Alexander K. Song, Megan Aumann, Ciaran M. Considine, Daniel O. Claassen, Manus J. Donahue
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Peri-sinus structures such as arachnoid granulations (AG) and the parasagittal dural (PSD) space have gained much recent attention as sites of cerebral spinal fluid (CSF) egress and neuroimmune surveillance. Neurofluid circulation
Externí odkaz:
https://doaj.org/article/530dea9866e74a5692c1c151d83a11d8
Autor:
Jarrod J. Eisma, Colin D. McKnight, Kilian Hett, Jason Elenberger, Caleb J. Han, Alexander K. Song, Ciaran Considine, Daniel O. Claassen, Manus J. Donahue
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background The choroid plexus functions as the blood-cerebrospinal fluid (CSF) barrier, plays an important role in CSF production and circulation, and has gained increased attention in light of the recent elucidation of CSF circulation dysfu
Externí odkaz:
https://doaj.org/article/d19b182c1aa74dad8a522a5900eb7c3c
Autor:
Elena Solopova, Wilber Romero-Fernandez, Hannah Harmsen, Lissa Ventura-Antunes, Emmeline Wang, Alena Shostak, Jose Maldonado, Manus J. Donahue, Daniel Schultz, Thomas M. Coyne, Andreas Charidimou, Matthew Schrag
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract We report the case of a 79-year-old woman with Alzheimer’s disease who participated in a Phase III randomized controlled trial called CLARITY-AD testing the experimental drug lecanemab. She was randomized to the placebo group and subsequen
Externí odkaz:
https://doaj.org/article/980393b02c7a4f79b9007c599dd91386
Autor:
Paula Trujillo, Alexander K. Song, Kaitlyn R. Hay, Megan Aumann, Yan Yan, Hakmook Kang, Manus J. Donahue, Daniel O. Claassen
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-7 (2022)
Abstract Impulsivity is inherent to behavioral disorders such as substance abuse and binge eating. While the role of dopamine in impulse behavior is well established, γ-aminobutyric acid (GABA) therapies have promise for the treatment of maladaptive
Externí odkaz:
https://doaj.org/article/f550958798004a4184c7b7065cd0d7a1
Autor:
Kilian Hett, Colin D. McKnight, Jarrod J. Eisma, Jason Elenberger, Jennifer S. Lindsey, Ciaran M. Considine, Daniel O. Claassen, Manus J. Donahue
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-13 (2022)
Abstract Background Recent studies have suggested alternative cerebrospinal fluid (CSF) clearance pathways for brain parenchymal metabolic waste products. One fundamental but relatively under-explored component of these pathways is the anatomic regio
Externí odkaz:
https://doaj.org/article/97d35ad6575d40ac933231d1887a941b
Autor:
R. Sky Jones, Manus J. Donahue, L. Taylor Davis, Sumit Pruthi, Spencer L. Waddle, Chelsea Custer, Niral J. Patel, Michael R. DeBaun, Adetola A. Kassim, Mark Rodeghier, Lori C. Jordan
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionSickle cell disease (SCD) increases cerebral infarct risk, but reported effects on brain volume have varied. More detailed information using larger cohorts and contemporary methods could motivate the use of longitudinal brain volume asses
Externí odkaz:
https://doaj.org/article/7a3cda7678494400b11625177b6cd744
Autor:
Ann T. Farrell, Julie Panepinto, C. Patrick Carroll, Deepika S. Darbari, Ankit A. Desai, Allison A. King, Robert J. Adams, Tabitha D. Barber, Amanda M. Brandow, Michael R. DeBaun, Manus J. Donahue, Kalpna Gupta, Jane S. Hankins, Michelle Kameka, Fenella J. Kirkham, Harvey Luksenburg, Shirley Miller, Patricia Ann Oneal, David C. Rees, Rosanna Setse, Vivien A. Sheehan, John Strouse, Cheryl L. Stucky, Ellen M. Werner, John C. Wood, William T. Zempsky
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 3982-4001 (2019)
Abstract: To address the global burden of sickle cell disease (SCD) and the need for novel therapies, the American Society of Hematology partnered with the US Food and Drug Administration to engage the work of 7 panels of clinicians, investigators, a
Externí odkaz:
https://doaj.org/article/94dcc43affc1405aa07a25c3738bac96