Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow‐up

Autor: Tomohiro Morio, Kentaro Endo, Nobutake Ozeki, Yoshinori Hasegawa, Mitsuru Mizuno, Ichiro Sekiya, Masaki Nomura, Naoki Amano, Hisako Katano, Naoko Takasu, Osamu Ohara, Hideyuki Koga

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 11, Pp 1530-1543 (2021)
Stem Cells Translational Medicine

Mesenchymal stem cells (MSCs) can show trisomy 7; however, the safety of these cells has not been fully investigated. The purposes of this study were to determine the ratio of patients whose synovial MSCs were transplanted clinically, to intensively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4debc41924d81b5d25f2562eae9e8bf5
https://doaj.org/article/82aae40d66d94edb8a750e0326874630

Coadministration of endothelial and smooth muscle cells derived from human induced pluripotent stem cells as a therapy for critical limb ischemia

Autor: Yang Woo Kwon, Chang-Seok Kim, Sang Mo Kwon, Da Sol Kim, Kinarm Ko, Sun Sik Bae, Jeong-Won Kim, Gyu Tae Park, Ye Seul Kim, Jin Ju Park, Jung Won Yoon, Jae Ho Kim

Publikováno v: Stem Cells Translational Medicine, Vol 10, Iss 3, Pp 414-426 (2021)
Stem Cells Translational Medicine

Critical limb ischemia is a condition in which tissue necrosis occurs due to arterial occlusion, resulting in limb amputation in severe cases. Both endothelial cells (ECs) and vascular smooth muscle cells (SMCs) are needed for the regeneration of per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05ff7148d382edee8c10a967f454f66
https://doaj.org/article/a17c1447f75744ffa9d3ec363982dae4

Mesenchymal stromal cells pretreated with pro‐inflammatory cytokines promote skin wound healing through VEGFC‐mediated angiogenesis

Autor: Qianwen Shang, Ying Wang, Gerry Melino, Yufang Shi, Lijuan Cao, Guozhong Lv, Mengting Zhu, Yongjing Chen, Jianchang Cao, Oscar K. Lee, Changshun Shao, Yunpeng Chu, Zhiyuan Zheng, Yanan Li

Publikováno v: Stem Cells Translational Medicine, Vol 9, Iss 10, Pp 1218-1232 (2020)
Stem Cells Translational Medicine

Skin is the largest organ of the human body. Skin wound is one of the most common forms of wound. Mesenchymal stromal cells (MSCs) have been used to aid skin wound healing via their paracrine factors. Because the secretome of MSCs can be greatly enri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbac2fc9117eaa45a3aba47b77e0e19f
https://doaj.org/article/95e227d6d28d47b7a07738afce53e162

Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration

Autor: Monica Aronsson, Anders Kvanta, Pankaj Kumar, Sara Padrell Sánchez, Fredrik Lanner, Helder André, Alvaro Plaza Reyes, Hammurabi Bartuma, Sandra Petrus-Reurer, Emeline F. Nandrot

Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, 2020, 9, pp.936-953. ⟨10.1002/sctm.19-0396⟩
Stem Cells Translational Medicine, Vol 9, Iss 8, Pp 936-953 (2020)
Stem Cells Translational Medicine, Wiley, 2020, 9, pp.936-953. ⟨10.1002/sctm.19-0396⟩

As pluripotent stem cell (PSC)‐based reparative cell therapies are reaching the bedside, there is a growing need for the standardization of studies concerning safety of the derived products. Clinical trials using these promising strategies are in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c0e54c212b317b23fb9947108ee411
https://doi.org/10.1002/sctm.19-0396

Facile bead-to-bead cell-transfer method for serial subculture and large-scale expansion of human mesenchymal stem cells in bioreactors

Autor: Yushi Sato, Katsuhiko Nakashima, Yasuhiko Tada, Shangwu Chen, Ryosuke Takahashi, Yuma Suzuki, Masahiro Okanojo

Publikováno v: Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 10, Iss 9, Pp 1329-1342 (2021)

The conventional planar culture of adherent cells is inefficient for large‐scale manufacturing of cell and gene therapy products. We developed a facile and efficient bead‐to‐bead cell‐transfer method for serial subculture and large‐scale ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e623914cda5bc4f7730859a6da65e4
https://pubmed.ncbi.nlm.nih.gov/34008349