Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Manuele Rebsamen"'
Autor:
Andras Boeszoermenyi, Léa Bernaleau, Xudong Chen, Felix Kartnig, Min Xie, Haobo Zhang, Sensen Zhang, Maeva Delacrétaz, Anna Koren, Ann-Katrin Hopp, Vojtech Dvorak, Stefan Kubicek, Daniel Aletaha, Maojun Yang, Manuele Rebsamen, Leonhard X. Heinz, Giulio Superti-Furga
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Dysregulation of pathogen-recognition pathways of the innate immune system is associated with multiple autoimmune disorders. Due to the intricacies of the molecular network involved, the identification of pathway- and disease-specific therap
Externí odkaz:
https://doaj.org/article/dc0ae7bb56a6425984c21f37fedceaaa
Autor:
Xudong Chen, Min Xie, Sensen Zhang, Marta Monguió-Tortajada, Jian Yin, Chang Liu, Youqi Zhang, Maeva Delacrétaz, Mingyue Song, Yixue Wang, Lin Dong, Qiang Ding, Boda Zhou, Xiaolin Tian, Haiteng Deng, Lina Xu, Xiaohui Liu, Zi Yang, Qing Chang, Jie Na, Wenwen Zeng, Giulio Superti-Furga, Manuele Rebsamen, Maojun Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Toll-like receptors (TLRs) are a class of proteins that play critical roles in recognizing pathogens and initiating innate immune responses. TASL, a recently identified innate immune adaptor protein for endolysosomal TLR7/8/9 signaling, is r
Externí odkaz:
https://doaj.org/article/7cfd7c5510254a58a60e7826c7afde97
Autor:
Haobo Zhang, Léa Bernaleau, Maeva Delacrétaz, Ed Hasanovic, Ales Drobek, Hermann Eibel, Manuele Rebsamen
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112916- (2023)
Summary: Endolysosomal Toll-like receptors (TLRs) play crucial roles in immune responses to pathogens, while aberrant activation of these pathways is associated with autoimmune diseases, including systemic lupus erythematosus (SLE). The endolysosomal
Externí odkaz:
https://doaj.org/article/6e5cfdfc81ad45c69d7f5c47d7b8e156
Autor:
Enrico Girardi, Gennaro Agrimi, Ulrich Goldmann, Giuseppe Fiume, Sabrina Lindinger, Vitaly Sedlyarov, Ismet Srndic, Bettina Gürtl, Benedikt Agerer, Felix Kartnig, Pasquale Scarcia, Maria Antonietta Di Noia, Eva Liñeiro, Manuele Rebsamen, Tabea Wiedmer, Andreas Bergthaler, Luigi Palmieri, Giulio Superti-Furga
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Maintenance of a mitochondrial NAD+ pool is critical for cellular life, yet the existence and identity of the transporter responsible for mitochondrial NAD+ uptake was unknown until recently. Here, the authors use genomic, genetic, and metabolomic ap
Externí odkaz:
https://doaj.org/article/e8ac6a683e1a429f8d643e2061a12835
Autor:
Eva Meixner, Ulrich Goldmann, Vitaly Sedlyarov, Stefania Scorzoni, Manuele Rebsamen, Enrico Girardi, Giulio Superti‐Furga
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 7, Pp n/a-n/a (2020)
Abstract Solute carriers (SLCs) are the largest family of transmembrane transporters in the human genome with more than 400 members. Despite the fact that SLCs mediate critical biological functions and several are important pharmacological targets, a
Externí odkaz:
https://doaj.org/article/4729b0d838f84270bf07a144b76beea3
Autor:
Leonhard X. Heinz, Christoph L. Baumann, Marielle S. Köberlin, Berend Snijder, Riem Gawish, Guanghou Shui, Omar Sharif, Irene M. Aspalter, André C. Müller, Richard K. Kandasamy, Florian P. Breitwieser, Andreas Pichlmair, Manuela Bruckner, Manuele Rebsamen, Stephan Blüml, Thomas Karonitsch, Astrid Fauster, Jacques Colinge, Keiryn L. Bennett, Sylvia Knapp, Markus R. Wenk, Giulio Superti-Furga
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1919-1928 (2015)
Lipid metabolism and receptor-mediated signaling are highly intertwined processes that cooperate to fulfill cellular functions and safeguard cellular homeostasis. Activation of Toll-like receptors (TLRs) leads to a complex cellular response, orchestr
Externí odkaz:
https://doaj.org/article/c15f42b992bc40058500731b1ade155b
Autor:
Manuele Rebsamen, Enrico Girardi, Vitaly Sedlyarov, Stefania Scorzoni, Konstantinos Papakostas, Manuela Vollert, Justyna Konecka, Bettina Guertl, Kristaps Klavins, Tabea Wiedmer, Giulio Superti-Furga
Publikováno v:
Life science alliance, vol. 5, no. 11, pp. e202201404
Life Science Alliance
Life Science Alliance
Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap,
Autor:
Celine Sin, Manuele Rebsamen, Ismet Srndic, Felix Kartnig, Jörg Menche, Meixner E, Felix Müller, Anna Skucha, Andreas Bergthaler, Sedlyarov, Ulrich Goldmann, Enrico Girardi, Giulio Superti-Furga, Benedikt Agerer, Giuseppe Fiume, Sabrina Lindinger
Solute Carriers (SLCs) represent the largest family of human transporter proteins, consisting of more than 400 members1,2. Despite the importance of these proteins in determining metabolic states and adaptation to environmental changes, a large propo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd23428e6825ff7750ec0d6815348820
https://doi.org/10.1101/2020.08.31.275818
https://doi.org/10.1101/2020.08.31.275818
Autor:
Ulrich Goldmann, Manuele Rebsamen, Vitaly Sedlyarov, Eva Meixner, Enrico Girardi, Stefania Scorzoni, Giulio Superti-Furga
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 16, Iss 7, Pp n/a-n/a (2020)
Molecular Systems Biology, Vol 16, Iss 7, Pp n/a-n/a (2020)
Solute carriers (SLCs) are the largest family of transmembrane transporters in the human genome with more than 400 members. Despite the fact that SLCs mediate critical biological functions and several are important pharmacological targets, a large pr
Autor:
Adrián César-Razquin, Manuele Rebsamen, Manuela Bruckner, Leonhard X. Heinz, Katrin Hörmann, Giulio Superti-Furga, Justyna Konecka, Astrid Fauster, Stefania Scorzoni, Fiorella Schischlik, Katharina L. Willmann, Johannes W. Bigenzahn, Enrico Girardi, Kaan Boztug
Publikováno v:
Cell Death and Differentiation
Cell Death & Differentiation
Cell Death & Differentiation
Regulation of cell and tissue homeostasis by programmed cell death is a fundamental process with wide physiological and pathological implications. The advent of scalable somatic cell genetic technologies creates the opportunity to functionally map su