Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Manuela Valsecchi"'
Autor:
Davide Sala, Francesca Ornaghi, Francesco Morena, Chiara Argentati, Manuela Valsecchi, Valeria Alberizzi, Roberta Di Guardo, Alessandra Bolino, Massimo Aureli, Sabata Martino, Angela Gritti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 170-189 (2022)
Genetic deficiency of β-N-acetylhexosaminidase (Hex) functionality leads to accumulation of GM2 ganglioside in Tay-Sachs disease and Sandhoff disease (SD), which presently lack approved therapies. Current experimental gene therapy (GT) approaches wi
Externí odkaz:
https://doaj.org/article/61bdd9f6fc0d43f78a06d041a2b5f2f0
Autor:
Francesca Ornaghi, Davide Sala, Fabiana Tedeschi, Maria Chiara Maffia, Martina Bazzucchi, Francesco Morena, Manuela Valsecchi, Massimo Aureli, Sabata Martino, Angela Gritti
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
The favorable outcome of in vivo and ex vivo gene therapy approaches in several Lysosomal Storage Diseases suggests that these treatment strategies might equally benefit GM2 gangliosidosis. Tay-Sachs and Sandhoff disease (the main forms of GM2 gangli
Externí odkaz:
https://doaj.org/article/e5ebadf6d2734a15bfc0f9c89dc37813
Autor:
Antonella Delle Fave, Marta Bassi, Beatrice Allegri, Sabina Cilia, Monica Falautano, Benedetta Goretti, Monica Grobberio, Eleonora Minacapelli, Marianna Pattini, Erika Pietrolongo, Manuela Valsecchi, Maria Pia Amato, Alessandra Lugaresi, Francesco Patti
Publikováno v:
Frontiers in Psychology, Vol 8 (2017)
The experience of persons with multiple sclerosis (MS) and their caregivers is usually investigated in terms of emotional distress and health-related quality of life, while well-being indicators remain largely underexplored. In addition, findings are
Externí odkaz:
https://doaj.org/article/355c5956b7204d9390c201cf81bb3e3d
Autor:
Manuela Valsecchi, Massimo Aureli, Laura Mauri, Giuditta Illuzzi, Vanna Chigorno, Alessandro Prinetti, Sandro Sonnino
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 7, Pp 1832-1840 (2010)
The dihydroceramide, ceramide, sphingomyelin, lactosylceramide, and ganglioside species of A2780 human ovarian carcinoma cells treated with the synthetic retinoids N-(4-hydroxyphenyl)retinamide (fenretinide, 4-HPR) and 4-oxo-N-(4-hydroxyphenyl)retina
Externí odkaz:
https://doaj.org/article/9369513b8fac414aa4643b20545a1d66
Autor:
Manuela Valsecchi, Laura Mauri, Riccardo Casellato, Simona Prioni, Nicoletta Loberto, Alessandro Prinetti, Vanna Chigorno, Sandro Sonnino
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 2, Pp 417-424 (2007)
The ceramide (Cer) and sphingomyelin (SM) species of cultured differentiated rat cerebellar granule cells and human fibroblasts were characterized by electrospray ionization-mass spectrometry. We identified 35 different species of Cer and 18 species
Externí odkaz:
https://doaj.org/article/1f676a8b8ff24166ac0d3710bd23a42d
Autor:
Xiqian Lan, Pravin C. Singhal, Manuela Valsecchi, Joanna Mikulak, Moin A. Saleem, Valentina Cazzetta, Massimo Aureli, Ferdinando Oriolo, Domenico Mavilio, Rocco Piazza
Publikováno v:
Glycoconjugate Journal
Apolipoprotein L1 (APOL1) wild type (G0) plays a role in the metabolism of sphingolipids, glycosphingolipids, sphingomyelin and ceramide, which constitute bioactive components of the lipid rafts (DRM). We asked whether APOL1 variants (APOL1-Vs) G1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394585106b03161c82dc709228ed5648
https://doi.org/10.1007/s10719-020-09944-w
https://doi.org/10.1007/s10719-020-09944-w
Autor:
Maria Fazzari, Giulia Lunghi, Pamela Fato, Maura Samarani, Erika Di Biase, Maria Grazia Ciampa, Diego Yuri Pomè, Simona Prioni, Manuela Valsecchi, Margherita Maggioni, Sandro Sonnino, Elena Chiricozzi, Laura Mauri
Publikováno v:
Glycoconjugate Journal. 37:329-343
It has been recently reported by our group that GM1-oligosaccharide added to neuroblastoma cells or administered to mouse experimental model mimics the neurotrophic and neuroprotective properties of GM1 ganglioside. In addition to this, differently f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3577ac02658450d970b7a677587afd32
https://doi.org/10.1007/s10719-020-09919-x
https://doi.org/10.1007/s10719-020-09919-x
Autor:
Elena Chiricozzi, Margherita Maggioni, Maria Fazzari, Erika Di Biase, Pamela Fato, Gianluca Verlengia, Gusheng Wu, Diego Yuri Pomè, Simona Prioni, Giulia Lunghi, Laura Mauri, Stefano Cattaneo, Robert Assini, Sandro Sonnino, Robert W. Ledeen, Nicoletta Loberto, Samar K. Alselehdar, Manuela Valsecchi, Maria Grazia Ciampa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1+/− mice, a model of sporadic Parkinson’s diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb574fc4f6a4bc857fd588d7d5193af4
http://link.springer.com/article/10.1038/s41598-019-55885-2
http://link.springer.com/article/10.1038/s41598-019-55885-2
Autor:
Elena, Chiricozzi, Massimo, Aureli, Laura, Mauri, Erika, Di Biase, Giulia, Lunghi, Maria, Fazzari, Manuela, Valsecchi, Emma Veronica, Carsana, Nicoletta, Loberto, Alessandro, Prinetti, Sandro, Sonnino
Publikováno v:
Advances in experimental medicine and biology. 1325
Glycosphingolipids are amphiphilic plasma membrane components formed by a glycan linked to a specific lipid moiety. In this chapter we report on these compounds, on their role played in our cells to maintain the correct cell biology.In detail, we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67f538b0f722727ddb9c9e406dc37699
https://pubmed.ncbi.nlm.nih.gov/34495530
https://pubmed.ncbi.nlm.nih.gov/34495530
Autor:
Maria Chiara Maffia, Francesco Morena, Fabiana Tedeschi, Manuela Valsecchi, Francesca Ornaghi, Massimo Aureli, Martina Bazzucchi, Angela Gritti, Davide Sala, Sabata Martino
Publikováno v:
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
The favorable outcome of in vivo and ex vivo gene therapy approaches in several Lysosomal Storage Diseases suggests that these treatment strategies might equally benefit GM2 gangliosidosis. Tay-Sachs and Sandhoff disease (the main forms of GM2 gangli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b90519f5c31319b1ca905eb61126b11
http://www.sciencedirect.com/science/article/pii/S0969996119303420
http://www.sciencedirect.com/science/article/pii/S0969996119303420