Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Manuela Tumiati"'
Autor:
Fernando Perez-Villatoro, Jaana Oikkonen, Julia Casado, Anastasiya Chernenko, Doga C. Gulhan, Manuela Tumiati, Yilin Li, Kari Lavikka, Sakari Hietanen, Johanna Hynninen, Ulla-Maija Haltia, Jaakko S. Tyrmi, Hannele Laivuori, Panagiotis A. Konstantinopoulos, Sampsa Hautaniemi, Liisa Kauppi, Anniina Färkkilä
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-13 (2022)
Abstract Homologous recombination DNA-repair deficiency (HRD) is a common driver of genomic instability and confers a therapeutic vulnerability in cancer. The accurate detection of somatic allelic imbalances (AIs) has been limited by methods focused
Externí odkaz:
https://doaj.org/article/1510497742624a49b8fc5fba11d6c5dc
Autor:
Heli Kuisma, Simona Bramante, Kristiina Rajamäki, Lauri J. Sipilä, Eevi Kaasinen, Jaana Kaukomaa, Kimmo Palin, Netta Mäkinen, Jari Sjöberg, Nanna Sarvilinna, Jussi Taipale, Liisa Kauppi, Manuela Tumiati, Antti Hassinen, Janne Pitkäniemi, Jyrki Jalkanen, Sanna Heikkinen, Annukka Pasanen, Oskari Heikinheimo, Ralf Bützow, Niko Välimäki, Lauri A. Aaltonen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Many factors have been associated with chromosomal damage, including mechanical forces in a constrained cellular environment. Here the authors reveal an association between parity and chromosomal damage by analysing karyotypes of 1946 uterine leiomyo
Externí odkaz:
https://doaj.org/article/d2e867958c8a4229a73872634dd5e339
Autor:
Arafat Siddiqui, Manuela Tumiati, Alia Joko, Jouko Sandholm, Pia Roering, Sofia Aakko, Reetta Vainionpää, Katja Kaipio, Kaisa Huhtinen, Liisa Kauppi, Johanna Tuomela, Sakari Hietanen
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Critical DNA repair pathways become deranged during cancer development. This vulnerability may be exploited with DNA-targeting chemotherapy. Topoisomerase II inhibitors induce double-strand breaks which, if not repaired, are detrimental to the cell.
Externí odkaz:
https://doaj.org/article/6a72803515b2449c90dd67582d36c593
Autor:
Sanna Pikkusaari, Manuela Tumiati, Anni Virtanen, Jaana Oikkonen, Yilin Li, Fernando Perez-Villatoro, Taru Muranen, Matilda Salko, Kaisa Huhtinen, Anna Kanerva, Heidi Koskela, Johanna Tapper, Riitta Koivisto-Korander, Titta Joutsiniemi, Ulla-Maija Haltia, Heini Lassus, Sampsa Hautaniemi, Anniina Färkkilä, Johanna Hynninen, Sakari Hietanen, Olli Carpén, Liisa Kauppi
Publikováno v:
Clinical Cancer Research. :OF1-OF14
Purpose: Deficiency in homologous recombination (HR) repair of DNA damage is characteristic of many high-grade serous ovarian cancers (HGSC). It is imperative to identify patients with homologous recombination–deficient (HRD) tumors as they are mos
Autor:
Liisa Kauppi, Olli Carpén, Sakari Hietanen, Johanna Hynninen, Anniina Färkkilä, Sampsa Hautaniemi, Heini Lassus, Ulla-Maija Haltia, Titta Joutsiniemi, Riitta Koivisto-Korander, Johanna Tapper, Heidi Koskela, Anna Kanerva, Kaisa Huhtinen, Matilda Salko, Taru Muranen, Fernando Perez-Villatoro, Yilin Li, Jaana Oikkonen, Anni Virtanen, Manuela Tumiati, Sanna Pikkusaari
Comparison of different fHR score cut-off values.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf2368cec2030b2f5e654a9ea7cd9ca
https://doi.org/10.1158/1078-0432.22490492
https://doi.org/10.1158/1078-0432.22490492
Autor:
Liisa Kauppi, Olli Carpén, Sakari Hietanen, Johanna Hynninen, Anniina Färkkilä, Sampsa Hautaniemi, Heini Lassus, Ulla-Maija Haltia, Titta Joutsiniemi, Riitta Koivisto-Korander, Johanna Tapper, Heidi Koskela, Anna Kanerva, Kaisa Huhtinen, Matilda Salko, Taru Muranen, Fernando Perez-Villatoro, Yilin Li, Jaana Oikkonen, Anni Virtanen, Manuela Tumiati, Sanna Pikkusaari
Tumor percentages estimated from H&E images and comparison between HR, ovaHRDScar and Telli2016 status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5165fb84f8b6675c836c0e78cbb3859a
https://doi.org/10.1158/1078-0432.22490483.v1
https://doi.org/10.1158/1078-0432.22490483.v1
Autor:
Liisa Kauppi, Olli Carpén, Sakari Hietanen, Johanna Hynninen, Anniina Färkkilä, Sampsa Hautaniemi, Heini Lassus, Ulla-Maija Haltia, Titta Joutsiniemi, Riitta Koivisto-Korander, Johanna Tapper, Heidi Koskela, Anna Kanerva, Kaisa Huhtinen, Matilda Salko, Taru Muranen, Fernando Perez-Villatoro, Yilin Li, Jaana Oikkonen, Anni Virtanen, Manuela Tumiati, Sanna Pikkusaari
Purpose:Deficiency in homologous recombination (HR) repair of DNA damage is characteristic of many high-grade serous ovarian cancers (HGSC). It is imperative to identify patients with homologous recombination–deficient (HRD) tumors as they are most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576b149b8d2a58ae9d5515d1e7fccb01
https://doi.org/10.1158/1078-0432.c.6533165
https://doi.org/10.1158/1078-0432.c.6533165
Publikováno v:
Proceedings of the 12th International Conference on Biomedical Engineering and Technology.
Autor:
Fernando Perez-Villatoro, Jaana Oikkonen, Julia Casado, Anastasiya Chernenko, Doga C. Gulhan, Manuela Tumiati, Yilin Li, Kari Lavikka, Sakari Hietanen, Johanna Hynninen, Ulla-Maija Haltia, Jaakko S. Tyrmi, Hannele Laivuori, Panagiotis A. Konstantinopoulos, Sampsa Hautaniemi, Liisa Kauppi, Anniina Färkkilä
Homologous recombination DNA-repair deficiency (HRD) is a common driver of genomic instability and confers a therapeutic vulnerability in cancer. The accurate detection of somatic allelic imbalances (AIs) has been limited by methods focused onBRCA1/2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1cd54f7cea89a7e02467a78e3f77af8
https://doi.org/10.1101/2021.08.19.456809
https://doi.org/10.1101/2021.08.19.456809
Autor:
Manuela Tumiati, Sirpa Leppä, Ville Rantanen, Chiara Facciotto, Julia Casado, Rainer Lehtonen, Liisa Kauppi, Krister Wennerberg, Sampsa Hautaniemi, Laura Turunen, Suvi-Katri Leivonen
Publikováno v:
Clinical Epigenetics
Background The epigenome plays a key role in cancer heterogeneity and drug resistance. Hence, a number of epigenetic inhibitors have been developed and tested in cancers. The major focus of most studies so far has been on the cytotoxic effect of thes