Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Manuela Simonetti"'
Autor:
Manuela Simonetti, Daniela Mauceri
Publikováno v:
Cells, Vol 12, Iss 8, p 1126 (2023)
Chronic pain affects a significant amount of the population and is responsible for vast worldwide socio-economic costs [...]
Externí odkaz:
https://doaj.org/article/f3f7fb03eec6445dbc6ec7fedc8a8b38
Publikováno v:
Cells, Vol 12, Iss 2, p 284 (2023)
Drugs enhancing the availability of noradrenaline are gaining prominence in the therapy of chronic neuropathic pain. However, underlying mechanisms are not well understood, and research has thus far focused on α2-adrenergic receptors and neuronal ex
Externí odkaz:
https://doaj.org/article/e1455e70dc3f4b0db10d27d0e8b55865
Autor:
Elisa Damo, Manuela Simonetti
Publikováno v:
Cells, Vol 11, Iss 19, p 3143 (2022)
Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community. Developmental molecules suc
Externí odkaz:
https://doaj.org/article/8dfba3227d0a47019ceae47072f944a5
Autor:
Eszter Paldy, Manuela Simonetti, Thomas Worzfeld, Kiran Kumar Bali, Lucas Vicuña, Stefan Offermanns, Rohini Kuner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Semaphorins and their receptors are involved in neurodevelopment, but their functions in the adult nervous system are not fully understood. This study finds that semaphorin 4C and its receptor Plexin B are expressed in sensory neurons and are pronoci
Externí odkaz:
https://doaj.org/article/527b909c401a4c5ebcc7de37bff5164a
Autor:
Rangel Silva, Phillip Rieder, Frank Kirchhoff, Manuela Simonetti, Amit Agarwal, Elisa Damo, Ilknur Coban
Publikováno v:
Neuroforum. 28:85-94
Several forms of chronic pain do not respond to the conventional analgesics, such as opioids, but can be treated with antidepressants, such as serotonin and noradrenalin reuptake inhibitors (SNRIs). Recent studies indicate that noradrenalin signallin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e727adb20c1fae6147f474e3ee45d29
https://doi.org/10.1515/nf-2021-0036
https://doi.org/10.1515/nf-2021-0036
Publikováno v:
Cells; Volume 12; Issue 2; Pages: 284
Drugs enhancing the availability of noradrenaline are gaining prominence in the therapy of chronic neuropathic pain. However, underlying mechanisms are not well understood, and research has thus far focused on α2-adrenergic receptors and neuronal ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0e4b31b0bef32f0998094d4862ef72
Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of persistent pain
Autor:
Sebastián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Hagen Wende, Katrin Schrenk-Siemens, Anna A. DePaoli-Roach, Anna M. Hagenston, Anke Tappe-Theodor, Manuela Simonetti, Rohini Kuner, Thomas Fleming, Jan Siemens
Long-lasting pain stimuli can trigger maladaptive changes in the spinal cord, reminiscent of plasticity associated with memory formation. Metabolic coupling between astrocytes and neurons has been implicated in neuronal plasticity and memory formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::371da4c40f6793037b14a7b628fac1cc
https://doi.org/10.1101/2022.12.03.518519
https://doi.org/10.1101/2022.12.03.518519
Autor:
Manuela Simonetti, Elisa Damo
Publikováno v:
Cells. 11(19)
Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community. Developmental molecules suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae840fe6aacfe48c242b70632a4b99c
https://pubmed.ncbi.nlm.nih.gov/36231105
https://pubmed.ncbi.nlm.nih.gov/36231105
Autor:
Rohini Kuner, Manuela Simonetti
Publikováno v:
Neuron. 109:1413-1416
How genetic loss of the sodium channel NaV1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, NaV1.7 channels at central terminals of pain-sensing afferents play a pivotal ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8105d62f20f4c3cfff5c04a55349b308
https://doi.org/10.1016/j.neuron.2021.04.011
https://doi.org/10.1016/j.neuron.2021.04.011
Autor:
Manuela Simonetti, Rohini Kuner
Publikováno v:
J Neurosci
Wnt signaling represents a highly versatile signaling system, which plays critical roles in developmental morphogenesis as well as synaptic physiology in adult life and is implicated in a variety of neural disorders. Recently, we demonstrated that Wn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f200f6a26332940150dde1207f797430
https://doi.org/10.1523/jneurosci.2942-19.2020
https://doi.org/10.1523/jneurosci.2942-19.2020