Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial

Autor: Tilman Reiff, Hans-Henning Eckstein, Ulrich Mansmann, Olav Jansen, Gustav Fraedrich, Harald Mudra, Dittmar Böckler, Michael Böhm, E Sebastian Debus, Jens Fiehler, Klaus Mathias, Erich B Ringelstein, Jürg Schmidli, Robert Stingele, Ralf Zahn, Thomas Zeller, Wolf-Dirk Niesen, Kristian Barlinn, Andreas Binder, Jörg Glahn, Werner Hacke, Peter Arthur Ringleb, Friedhelm Beyersdorf, Roland-Richard Macharzina, Gabriele Lechner, Carolin Menz, Sabine Schonhardt, Michael Weinbeck, Olga Greb, Dagmar Otto, Thomas Winker, Hermann Berger, Holger Poppert, Andreas Kühnl, Volker Pütz, Kathrin Haase, Ulf Bodechtel, Norbert Weiss, Hendrik Bergert, Johannes Meyne, Justus Groß, Matthias Kruse, Berthold Gerdes, Wolf-Dieter Reinbold, Helge Wuttig, Andreas Maier-Hasselmann, Manuela Segerer, Hans-Hermann Fuchs, Sabine Gass, Christoph Groden, Marco Niedergethmann, Martin Griebe, Michael Rosenkranz, Jürgen Beck, Götz Thomalla, Hermann H. Zeumer, Marek Jauß, Werner Kneist, Martina Kneist, Thomas Staudacher, Alfons Bernhard, Petra Jost, Nico Prey, Jürgen Knippschild, Oliver Kastrup, Martin Köhrmann, Benedikt Frank, Volkmar Bongers, Johannes Hoffmann, Horst-Wilhelm Kniemeyer, Michael Knauth, Kathrin Wasser, Tomislav Stojanovic, Hans Emmert, Josef Tacke, Bernhard Schwalbe, Eun-Mi Nam, Ulrike van Lengerich, Stephan Lowens, Klaus Gröschel, Timo Uphaus, Sonja Gröschel, Stephan Boor, Bernhard Dorweiler, Elisabeth Schmid, Hans Henkes, Thomas Hupp, Oliver Singer, Gerhard Hamann, Michaela Wagner-Heck, Sibylle Kerth-Krick, Metin Kilic, Peter Huppert, Kurt Niederkorn, Johannes Fruhwirth, Günther Klein, Ulrich Pulkowski, Karsten Jöster, Jens-Henning Wacks, Egbert Kloppmann, Bijan Vatankhah, Silke Hopf-Jensen, Henning Stolze, Stefan Müller-Hülsbeck, Knut Peer Walluscheck, Hans-Michael Schmitt, Albert Grüger, Jörg Seemann, Belay Tilahun, Martin Dichgans, Frank Arne Wollenweber, Angelika Dörr, Adelgunde Zollver, Gabor Gäbel, Günter Hedtmann, Rainer Kollmar, Detlef Claus, Christian Petermann, Stefanie Kirsch, Branko Bosnjak, Johannes Heiß, Holger Mühling, Silke Wunderlich, Peter Nikolaus Sabisch, Georg Gahn, Martin Storck, Sebastian Arnold, Urs Fischer, Jan Gralla, Matthias von Mering, Rüdiger Dißmann, Delia Kirsch, Christoph Schmidauer, Peter Waldenberger, Martin Furtner, Haiko Kazarians, Peter Breuer, Christian Arning, Jürgen Rieper, Georg Schmidt, Marcel Arnold, Gerhard Schroth, Jens Weise, Jürgen Zanow, Thomas Mayer, Rudolf Töpper, Walter Gross-Fengels, Harald Daum, Ralf Dittrich, Martin Ritter, Bernd Kasprzak, Giovanni Torsello, Carsten Pohlmann, Roland Brüning, Alexander Crispin, Miriam Hofmann, Thomas Müller, Erwin Blessing, Markus Möhlenbruch, Ines Ludwig, Hemasse Amiri

Publikováno v: The Lancet Neurology. 21:877-888

The optimal treatment for patients with asymptomatic carotid artery stenosis is under debate. Since best medical treatment (BMT) has improved over time, the benefit of carotid endarterectomy (CEA) or carotid artery stenting (CAS) is unclear. Randomis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd3183ef64d9c0d46c928b337f093b2
https://doi.org/10.1016/s1474-4422(22)00290-3

Carotid artery stenting in clinical practice depending on patient age

Autor: Harald Mudra, Henning Strohm, Stephan Staubach, Jakob Ledwoch, Manuela Segerer

Publikováno v: Catheterization and Cardiovascular Interventions. 90:451-460

Background The age-dependent outcome of carotid artery stenting (CAS) outside of randomized controlled trials is largely unknown. Therefore, we assessed acute and long-term results of CAS in a single-center real-world registry. Methods All symptomati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::343f5b938c85cb82b591a609ef25fbd8
https://doi.org/10.1002/ccd.27127

Stroke rates after carotid artery stenting depend on study-specific definitions

Autor: Manuela Segerer, Harald Mudra, Stephan Staubach, Jakob Ledwoch, Henning Strohm, Katharina Soekeland

Publikováno v: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 12(4)

Aims There is no consensus definition for minor and major stroke in trials comparing CAS vs. CEA. In this study the patients of our large single-centre CAS registry suffering a procedure-related stroke were categorised as minor or major stroke accord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c7d46d02f48eff9bd2f4702448bb0e
https://pubmed.ncbi.nlm.nih.gov/27436603

Incidence and risk factors of embolized particles in carotid artery stenting and association with clinical outcome

Autor: Henning Strohm, Stephan Staubach, Harald Mudra, Jakob Ledwoch, Manuela Segerer

Publikováno v: International journal of cardiology. 227

Background One of the mechanisms for periprocedural neurologic events in carotid artery stenting (CAS) is catheter manipulation within the aorta and supraaortic arteries causing plaque embolization. Therefore, the present analysis sought to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce323a0e97d25c9aaec7a7313742a254
https://pubmed.ncbi.nlm.nih.gov/27829527

Oral interferon-α treatment of mice with cryoglobulinemic glomerulonephritis

Autor: Andrew G. Farr, Yan Cui, Stephan Segerer, Charles E. Alpers, Manuela Segerer, Min Wen, Kelly L. Hudkins, Sekiko Taneda

Publikováno v: American Journal of Kidney Diseases. 39:876-888

Cryoglobulins are associated with the development of a membranoproliferative glomerulonephritis, often referred to as cryoglobulinemic glomerulonephritis, particularly in the setting of hepatitis C virus infection. Parenteral interferon-alpha (IFN-al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f47e6f5d0540c70e8a5caa6135e482b
https://doi.org/10.1053/ajkd.2002.32011