New Perspectives of Immunosuppression

Autor: Tom Florian Fuller, Frank Friedersdorff, Mareen Matz, Manuela Schütz, Lu Huber, Klemens Budde, Fabian Halleck, Michael Dürr

Publikováno v: Transplantation Proceedings. 45:1224-1231

Efficient rejection prophylaxis and excellent short-term results in organ transplantation can not obscure the fact that long-term outcomes have not improved substantially over the last decade with rather constant graft attrition rates beyond the firs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b5223702a651fc41490660e98ddac7
https://doi.org/10.1016/j.transproceed.2013.02.033

Aktuelle Aspekte der Immunsuppression nach Nierentransplantation

Autor: L. Liefeldt, Manuela Schütz, Fritz Diekmann, Markus Giessing, Klemens Budde, Petra Glander, Hans-H. Neumayer

Publikováno v: Nieren- und Hochdruckkrankheiten. 37:602-613

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aada0f7296e7937a20095a13777d31d
https://doi.org/10.5414/nhp37602

Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma

Autor: Susanne Merkel, Nathalie Britzen-Laurent, Michael Stürzl, Daniela Regensburger, Tilman T. Rau, Alan Richard Clarke, Vera Schellerer, Patrick Kölbel, Lisa Haep, Elisabeth Naschberger, Ute Schaal, Thomas Wittmann, Barbara Dietel, Werner Hohenberger, Roland S. Croner, Andrea Liebl, Ludger Klein-Hitpass, Valerie Meniel, Manuela Schütz

Publikováno v: Naschberger, E.; Liebl, A.; Schellerer, V. S.; Schutz, M.; Britzen-Laurent, N.; Kolbel, P.; Schaal, U.; Haep, L.; Regensburger, D.; Wittmann, T.; Klein-Hitpass, L.; Rau, Tilman; Dietel, B.; Meniel, V. S.; Clarke, A. R.; Merkel, S.; Croner, R. S.; Hohenberger, W.; Sturzl, M. (2016). Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma. Journal of clinical investigation, 126(11), pp. 4187-4204. American Society for Clinical Investigation 10.1172/JCI78260

Different tumor microenvironments (TMEs) induce stromal cell plasticity that affects tumorigenesis. The impact of TME-dependent heterogeneity of tumor endothelial cells (TECs) on tumorigenesis is unclear. Here, we isolated pure TECs from human colore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570fc1fc55a3e90597342cc3e0426cfc

Reduced-exposure cyclosporine is safe and efficacious in de novo renal transplant recipients treated with enteric-coated mycophenolic acid and basiliximab

Autor: Petra Glander, Manuela Schütz, Martin Zeier, J. Sennesael, W. Fischer, Przemyslaw Pisarski, Klemens Budde, H.-H. Neumayer, J.L. Bosmans

Publikováno v: Clinical nephrology

Background: The lower limit of exposure to calcineurin inhibitors has not yet been established in de novo renal transplant patients receiving mycophenolic acid therapy with basiliximab. Methods: A 12-month, multicenter, randomized, open-label trial w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bf57c9ef6d91afaa89b176fc985cf9
https://doi.org/10.5414/cnp67164

FTY720 (fingolimod) in renal transplantation

Autor: Lutz Liefeldt, Hans-H. Neumayer, Torsten Böhler, Klemens Budde, Manuela Schütz, Petra Glander, Johannes Waiser, Harm Peters

Publikováno v: Clinical Transplantation. 20:17-24

FTY720 (Fingolimod) is a novel immunomodulator with a mode of action that is completely different from classical immunosuppressants. FTY is a structural and functional analogue of the natural serum lipid, sphingosine, and is the first in a new class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868e0bbaf6e33e08a02b1b6d0fd89f64
https://doi.org/10.1111/j.1399-0012.2006.00596.x