Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Manuela Rossol"'
Autor:
Veselina Radushev, Isabel Karkossa, Janina Berg, Martin von Bergen, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Matthias Blüher, Ulf Wagner, Kristin Schubert, Manuela Rossol
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionObesity is associated with a plethora of health complications, including increased susceptibility to infections or decreased vaccine efficacy, partly due to dysregulated immune responses. Monocytes play a crucial role in innate immunity,
Externí odkaz:
https://doaj.org/article/3c0f6472f2e7455c9082d531ecde85c1
Autor:
Supriya Murthy, Isabel Karkossa, Caroline Schmidt, Anne Hoffmann, Tobias Hagemann, Kathrin Rothe, Olga Seifert, Ulf Anderegg, Martin von Bergen, Kristin Schubert, Manuela Rossol
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract The danger signal extracellular calcium is pathophysiologically increased in the synovial fluid of patients with rheumatoid arthritis (RA). Calcium activates the NLRP3-inflammasome via the calcium-sensing receptor in monocytes/macrophages pr
Externí odkaz:
https://doaj.org/article/7f73afe06655423aa2e2b1408ca0f2aa
Autor:
Elisabeth Jäger, Supriya Murthy, Caroline Schmidt, Magdalena Hahn, Sarah Strobel, Anna Peters, Claudia Stäubert, Pelin Sungur, Tom Venus, Mandy Geisler, Veselina Radusheva, Stefanie Raps, Kathrin Rothe, Roger Scholz, Sebastian Jung, Sylke Wagner, Matthias Pierer, Olga Seifert, Wenhan Chang, Irina Estrela-Lopis, Nora Raulien, Knut Krohn, Norbert Sträter, Stephanie Hoeppener, Torsten Schöneberg, Manuela Rossol, Ulf Wagner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
How extracellular calcium can trigger Nlrp3 inflammasome activation has been somewhat controversial and unclear. Here the authors show calciprotein particles are taken up by myeloid cells via calcium-sensing receptor-dependent macropinocytosis in res
Externí odkaz:
https://doaj.org/article/13285a5fc1104c3ea401a9b5df22ded9
Autor:
Kathleen Friedrich, Miriam Sommer, Sarah Strobel, Stephan Thrum, Matthias Blüher, Ulf Wagner, Manuela Rossol
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Circulating monocytes can be divided into classical (CM), intermediate (IM), and non-classical monocytes (NCM), and the classical monocytes also contain CD56+ monocytes and monocytic myeloid-derived suppressor cells (M-MDSC). The aim of the study was
Externí odkaz:
https://doaj.org/article/cfb2a1eca48c4d158286cea5393de907
Autor:
Nora Raulien, Kathleen Friedrich, Sarah Strobel, Stefan Rubner, Sven Baumann, Martin von Bergen, Antje Körner, Martin Krueger, Manuela Rossol, Ulf Wagner
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Monocytes enter sites of microbial or sterile inflammation as the first line of defense of the immune system and initiate pro-inflammatory effector mechanisms. We show that activation with bacterial lipopolysaccharide (LPS) induces them to undergo a
Externí odkaz:
https://doaj.org/article/71cf90a8636b43909de2f52342d55cb5
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23539 (2011)
In rheumatoid arthritis, a significant proportion of cytokine and chemokine synthesis is attributed to innate immune mechanisms. TLR4 is a prominent innate receptor since several endogenous ligands known to activate the innate immune system bind to i
Externí odkaz:
https://doaj.org/article/1cf86345ea264f33be323839af221b03
Autor:
Stephan Thrum, Miriam Sommer, Nora Raulien, Martin Gericke, Lucas Massier, Peter Kovacs, Marco Krasselt, Kathrin Landgraf, Antje Körner, Arne Dietrich, Matthias Blüher, Manuela Rossol, Ulf Wagner
Publikováno v:
International Journal of Obesity. 46:1883-1891
Objective Obesity is complicated by inflammatory activation of the innate immune system. Stimulation of the calcium-sensing receptor (CaSR) by extra-cellular calcium ions ([Ca2+]ex) can trigger NLRP3 inflammasome activation and inflammation. We hypot
Autor:
S. Strobel, Manuela Rossol
Publikováno v:
Zeitschrift für Rheumatologie. 76:609-612
Autor:
Rowaida Refaat, Mennatallah A. Gowayed, Hanan S. El-Abhar, Ahmed S. Attia, Kathrin Rothe, Ulf Wagner, Christoph Baerwald, Manuela Rossol
Publikováno v:
Biochemical pharmacology. 170
Objective The evolution of the “cholinergic anti-inflammatory pathway” and the fact that the α 7 subunit of the nicotinic acetylcholine receptor (α7nAChR) is present in the spleen, joint and on the surface of lymphocytes, opened up the prospect
Autor:
Maria Klingner, Christoph Baerwald, R. Scholz, Simon Jasinski-Bergner, Manuela Rossol, Kristin Schubert, Dagmar Quandt, Barbara Seliger, Matthias Pierer, Kathrin Rothe, Ulf Wagner
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective Leukocyte immunoglobulin-like receptor 1 (LIR-1) is up-regulated by cytomegalovirus (CMV), which in turn, has been associated with premature aging and more severe joint disease in patients with rheumatoid arthritis (RA). The aim of this stu