Elucidating the signal responses of multi-parametric surface plasmon resonance living cell sensing: a comparison between optical modeling and drug-MDCKII cell interaction measurements.

Autor: Tapani Viitala, Niko Granqvist, Susanna Hallila, Manuela Raviña, Marjo Yliperttula

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72192 (2013)

In vitro cell-based assays are widely used during the drug discovery and development process to test the biological activity of new drugs. Most of the commonly used cell-based assays, however, lack the ability to measure in real-time or under dynamic

Externí odkaz: https://doaj.org/article/34c9b4b500b44b23962f1e37d7c3de80

Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models

Autor: Arto Urtti, Astrid Subrizi, Sanjay Sarkhel, Heli Skottman, Eva Ramsay, Neil R. Cameron, Jørgen Kjems, Sarah Hehir, Marika Ruponen, Tanja Ilmarinen, Manuela Raviña

Publikováno v: Pharmaceutics, Vol 12, Iss 667, p 667 (2020)
Pharmaceutics
Volume 12
Issue 7
Ramsay, E, Raviña, M, Sarkhel, S, Hehir, S, Cameron, N R, Ilmarinen, T, Skottman, H, Kjems, J, Urtti, A, Ruponen, M & Subrizi, A 2020, ' Avoiding the pitfalls of siRNA delivery to the retinal pigment epithelium with physiologically relevant cell models ', Pharmaceutics, vol. 12, no. 7, 667 . https://doi.org/10.3390/pharmaceutics12070667

Inflammation is involved in the pathogenesis of several age-related ocular diseases, such as macular degeneration (AMD), diabetic retinopathy, and glaucoma. The delivery of anti-inflammatory siRNA to the retinal pigment epithelium (RPE) may become a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa3134e1b32f7881de1292ee09d05c6
https://www.mdpi.com/1999-4923/12/7/667

Nanocarriers: siRNA Delivery

Autor: Alejandro Sánchez, Begoña Seijo, Jenny E. Parraga, Manuela Raviña

Publikováno v: Encyclopedia of Biomedical Polymers and Polymeric Biomaterials ISBN: 1439898790

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecc53039c03531f6a2378096ca6d13a8
https://doi.org/10.1081/e-ebpp-120049286

Core−Shell Dendriplexes with Sterically Induced Stoichiometry for Gene Delivery

Autor: Alejandro Sánchez, Juan Correa, Maria de la Fuente, Manuela Raviña, Ricardo Riguera, Ana Sousa-Herves, Jorge Pinto, María J. Alonso, Eduardo Fernandez-Megia

Publikováno v: Macromolecules. 43:6953-6961

The development of dendriplexes as nanoarchitectures with sterically induced stoichiometry for gene delivery applications is described. The ability of four generations of amino-functionalized gallic acid-triethylene glycol (GATG) dendrons and PEG-den

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9003c26cd7ca74c9ff1f562fb01b761a
https://doi.org/10.1021/ma100785m

Chitosan-based nanostructures: A delivery platform for ocular therapeutics

Autor: Manuela Raviña, Maria de la Fuente, Alejandro Sánchez, María J. Alonso, Begoña Seijo, Patrizia Paolicelli

Publikováno v: Advanced Drug Delivery Reviews. 62:100-117

Nanoscience and nanotechnology has caused important breakthroughs in different therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led to the development of novel strategies for the treatment of ocular disorders.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fff4261a6ec368764c1288afc15682d
https://doi.org/10.1016/j.addr.2009.11.026