Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Manuela Raviña"'
Autor:
Eva Ramsay, Manuela Raviña, Sanjay Sarkhel, Sarah Hehir, Neil R. Cameron, Tanja Ilmarinen, Heli Skottman, Jørgen Kjems, Arto Urtti, Marika Ruponen, Astrid Subrizi
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 667 (2020)
Inflammation is involved in the pathogenesis of several age-related ocular diseases, such as macular degeneration (AMD), diabetic retinopathy, and glaucoma. The delivery of anti-inflammatory siRNA to the retinal pigment epithelium (RPE) may become a
Externí odkaz:
https://doaj.org/article/7b014436c1e74f209f9ae13ee1014655
Autor:
Manuela Raviña, Kati-Sisko Vellonen, Maxim Antopolsky, Anu J. Airaksinen, Arto Urtti, Blanca Arango-Gonzalez, Eero Hippeläinen, Mechthild Schmitt
Publikováno v:
Molecular Pharmaceutics. 16:4399-4404
Preclinical in vivo tests of retinal drug responses are carried out in mice and rats, often after intravitreal injections. However, quantitative pharmacokinetics in the mouse eye is poorly understood. Ocular pharmacokinetics studies are usually done
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a833489fb708101641a574dfa06ec77b
https://doi.org/10.1021/acs.molpharmaceut.9b00679
https://doi.org/10.1021/acs.molpharmaceut.9b00679
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72192 (2013)
In vitro cell-based assays are widely used during the drug discovery and development process to test the biological activity of new drugs. Most of the commonly used cell-based assays, however, lack the ability to measure in real-time or under dynamic
Externí odkaz:
https://doaj.org/article/34c9b4b500b44b23962f1e37d7c3de80
Autor:
Arto Urtti, Astrid Subrizi, Sanjay Sarkhel, Heli Skottman, Eva Ramsay, Neil R. Cameron, Jørgen Kjems, Sarah Hehir, Marika Ruponen, Tanja Ilmarinen, Manuela Raviña
Publikováno v:
Pharmaceutics, Vol 12, Iss 667, p 667 (2020)
Pharmaceutics
Volume 12
Issue 7
Ramsay, E, Raviña, M, Sarkhel, S, Hehir, S, Cameron, N R, Ilmarinen, T, Skottman, H, Kjems, J, Urtti, A, Ruponen, M & Subrizi, A 2020, ' Avoiding the pitfalls of siRNA delivery to the retinal pigment epithelium with physiologically relevant cell models ', Pharmaceutics, vol. 12, no. 7, 667 . https://doi.org/10.3390/pharmaceutics12070667
Pharmaceutics
Volume 12
Issue 7
Ramsay, E, Raviña, M, Sarkhel, S, Hehir, S, Cameron, N R, Ilmarinen, T, Skottman, H, Kjems, J, Urtti, A, Ruponen, M & Subrizi, A 2020, ' Avoiding the pitfalls of siRNA delivery to the retinal pigment epithelium with physiologically relevant cell models ', Pharmaceutics, vol. 12, no. 7, 667 . https://doi.org/10.3390/pharmaceutics12070667
Inflammation is involved in the pathogenesis of several age-related ocular diseases, such as macular degeneration (AMD), diabetic retinopathy, and glaucoma. The delivery of anti-inflammatory siRNA to the retinal pigment epithelium (RPE) may become a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa3134e1b32f7881de1292ee09d05c6
https://www.mdpi.com/1999-4923/12/7/667
https://www.mdpi.com/1999-4923/12/7/667
Akademický článek
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Publikováno v:
Encyclopedia of Biomedical Polymers and Polymeric Biomaterials ISBN: 1439898790
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc53039c03531f6a2378096ca6d13a8
https://doi.org/10.1081/e-ebpp-120049286
https://doi.org/10.1081/e-ebpp-120049286
Autor:
Ricardo Riguera, Eduardo Fernandez-Megia, Ramon Novoa-Carballal, Eva Cubillo, David Olmeda, Alejandro Sánchez, Amparo Cano, María J. Alonso, Manuela Raviña
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
[Purpose]: To design hyaluronic acid (HA) and chitosan-g-poly (ethylene glycol) (CS-g-PEG) nanoparticles intended for a broad range of gene delivery applications. [Methods]: Nanoparticles formulated at different HA/CS-g-PEG mass ratios were developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cceb9922785f656e2ae2e8aa9199d907
https://doi.org/10.1007/s11095-010-0263-y
https://doi.org/10.1007/s11095-010-0263-y
Autor:
Alejandro Sánchez, Juan Correa, Maria de la Fuente, Manuela Raviña, Ricardo Riguera, Ana Sousa-Herves, Jorge Pinto, María J. Alonso, Eduardo Fernandez-Megia
Publikováno v:
Macromolecules. 43:6953-6961
The development of dendriplexes as nanoarchitectures with sterically induced stoichiometry for gene delivery applications is described. The ability of four generations of amino-functionalized gallic acid-triethylene glycol (GATG) dendrons and PEG-den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9003c26cd7ca74c9ff1f562fb01b761a
https://doi.org/10.1021/ma100785m
https://doi.org/10.1021/ma100785m
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 10:73-86
The aim of this review is to provide the reader with an overview on the potential of dendritic polymers in the antisense delivery technology. Special emphasis has been placed on the different types of dendritic structures that have been reported and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe67d5b9bcbc2bdfb8a882053cf6b98
https://doi.org/10.2174/138955710791112569
https://doi.org/10.2174/138955710791112569
Autor:
Manuela Raviña, Maria de la Fuente, Alejandro Sánchez, María J. Alonso, Begoña Seijo, Patrizia Paolicelli
Publikováno v:
Advanced Drug Delivery Reviews. 62:100-117
Nanoscience and nanotechnology has caused important breakthroughs in different therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led to the development of novel strategies for the treatment of ocular disorders.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fff4261a6ec368764c1288afc15682d
https://doi.org/10.1016/j.addr.2009.11.026
https://doi.org/10.1016/j.addr.2009.11.026