Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Manuela Polydoro"'
Autor:
Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau prot
Externí odkaz:
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Fiona Elwood, John Alford, Carsten Russ, Christopher Acker, Audrey Gray, John S. Reece-Hoyes, Carlos G Sanchez, Sarah J. Luchansky, Christian Doherty, Lucas Craig, Gregory McAllister, Steven Paula, Ricardo E. Dolmetsch, Shaojian An, Cheng Song, Alicia Lindeman, Malini Varadarajan, Nadire Cochran, Manuela Polydoro, Ketthsy Capre, Gregory R. Hoffman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a06bbe1da74cbde2af5f7fb1d3fc80e
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Publikováno v:
Neurosci Lett
Tauopathies are a group of over 20 clinicopathological neurodegenerative diseases including Alzheimer's disease (AD), the most common type of dementia, progressive supranuclear palsy, Pick's disease, corticobasal degeneration, among others. Tauopathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7722bc1a654069f31f67a6f36f0c5ddf
https://europepmc.org/articles/PMC9212860/
https://europepmc.org/articles/PMC9212860/
Autor:
Bradley T. Hyman, Laura Sanchez, Dennis W. Dickson, Yan Ren, Tara L. Spires-Jones, Naruhiko Sahara, Carolina Ceballos, Wen Lang Lin, Manuela Polydoro
Publikováno v:
Journal of Alzheimer's disease : JAD. 38(3):589-600
Tau belongs to the microtubule-associated family of proteins that maintain cytoskeletal structure by regulating micro- tubule dynamics. In certain neurodegenerative diseases termed tauopathies, tau is abnormally phosphorylated and accumulates as fila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14a84f8adaf49e0a68e44225ac0a921
https://repo.qst.go.jp/records/46863
https://repo.qst.go.jp/records/46863
Autor:
Kevin R Kay, Tara L. Spires-Jones, Laura Sanchez, Amy M. Pooler, Teresa Gomez-Isla, Rose Pitstick, Bradley T. Hyman, George A. Carlson, Manuela Polydoro, Susanne Wegmann, Mark W. Albers
Publikováno v:
Journal of Comparative Neurology. 521:4236-4248
Early observations of the patterns of neurofibrillary tangles and amyloid plaques in Alzheimer's disease suggested a hierarchical vulnerability of neurons for tangles, and a widespread nonspecific pattern of plaques that nonetheless seemed to correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e617a76297cad90929c4b6d5c193905
https://doi.org/10.1002/cne.23411
https://doi.org/10.1002/cne.23411
Autor:
Jennifer I. Luebke, Johanna L. Crimins, Manuela Polydoro, Amy M. Pooler, Tara L. Spires-Jones
Publikováno v:
Ageing Research Reviews. 12:757-763
The synaptic connections that form between neurons during development remain plastic and able to adapt throughout the lifespan, enabling learning and memory. However, during aging and in particular in neurodegenerative diseases, synapses become dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1936b8f51a656c27d9dfc9a2aea9c12d
https://doi.org/10.1016/j.arr.2013.03.002
https://doi.org/10.1016/j.arr.2013.03.002
Autor:
David S. Miller, Marion Wittmann, Eva-Maria Mandelkow, Susanne Ostrowitzki, Michel Goedert, Lisa J. Bain, James Hendrix, Laura M. Gault, Michael Hutton, David M. Holtzman, Ana M. Catafau, Manuela Polydoro, Sean M. Smith, Eckhard Mandelkow, Maria C. Carrillo
Publikováno v:
Alzheimer's and dementia 12(10), 1033-1039 (2016). doi:10.1016/j.jalz.2016.03.018
Alzheimer's Association Research Roundtable Fall 2015-Tau: From research to clinical development. Tau pathology is recognized as the key driver of disease progression in Alzheimer's and other neurodegenerative diseases. Although this makes tau an att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234551578d4e54d18251aa5a4c4365d2
Autor:
Andrew M. Williams, Manuela Polydoro, Megumi Morimoto-Tomita, Pablo E. Castillo, Ning Tian, Ling Diao, Vladimir L. Buchman, Sachin Makani, Becket Greten-Harrison, Esther H. Nie, Sreeganga S. Chandra
Publikováno v:
Proceedings of the National Academy of Sciences. 107:19573-19578
Synucleins are a vertebrate-specific family of abundant neuronal proteins. They comprise three closely related members, α-, β-, and γ-synuclein. α-Synuclein has been the focus of intense attention since mutations in it were identified as a cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b9a79dc12dc3d08cbf95936f901ca7
https://doi.org/10.1073/pnas.1005005107
https://doi.org/10.1073/pnas.1005005107
Autor:
José Cláudio Fonseca Moreira, Patricia Budni, Maria Noêmia Martins de Lima, Manuela Polydoro, Nadja Schröder, Felipe Dal-Pizzol
Publikováno v:
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Increased levels of iron in specific brain regions have been reported in neurodegenerative disorders. It has been postulated that iron exerts its deleterious effects on the nervous system by inducing oxidative damage. In a previous study, we have sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c3805f02bdd5d9f25d689c69dbef86
https://doi.org/10.1007/s11064-006-9249-x
https://doi.org/10.1007/s11064-006-9249-x
Autor:
Brandley T. Hyman, Laiq-Jan Saidi, Tara L. Spires-Jones, Eva-Maria Mandelkow, Manuela Polydoro, Kevin R Kay, Laura Sanchez
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's disease 44(3), 937-947 (2015). doi:10.3233/JAD-142094
Journal of Alzheimer's disease 44(3), 937-947 (2015). doi:10.3233/JAD-142094
One of the hallmarks of Alzheimer's disease is the formation of neurofibrillary tangles, intracellular aggregates of hyperphosphorylated, mislocalized tau protein, which are associated with neuronal loss. Changes in tau are known to impair cellular t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d06a6bec55b4ee6ec3914b04abd5809
https://hdl.handle.net/11858/00-001M-0000-0029-70CA-011858/00-001M-0000-0029-70CC-C
https://hdl.handle.net/11858/00-001M-0000-0029-70CA-011858/00-001M-0000-0029-70CC-C