A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target

Autor: Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard, Manuela Mazzuferi, Andree Delahaye-Duriez, Juliette Van Steenwinckel, Pierre Gressens, Benedicte Danis, Catherine Vandenplas, Patrik Foerch, Karine Leclercq, Georges Mairet-Coello, Alvaro Cardenas, Frederic Vanclef, Liisi Laaniste, Isabelle Niespodziany, James Keaney, Julien Gasser, Gaelle Gillet, Kirill Shkura, Seon-Ah Chong, Jacques Behmoaras, Irena Kadiu, Enrico Petretto, Rafal M. Kaminski, Michael R. Johnson

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify

Externí odkaz: https://doaj.org/article/c0cffc3635504945bbe2f39f8175da2f

A Systems-Level Framework for Drug Discovery Identifies Csf1R As A Novel Anti-Epileptic Drug Target

Autor: Bénédicte Danis, Catherine Vandenplas, Manuela Mazzuferi, Andrée Delahaye-Duriez, Liisi Laaniste, Prashant K. Srivastava, Patrik Foerch, Enrico Petretto, Marvin Johnson, Patrice Godard, Rafal M. Kaminski, Karine Leclercq, Kirill Shkura, Frederic Vanclef, Jonathan van Eyll, Georges Mairet-Coello

The identification of mechanistically novel drug targets is highly challenging, particularly for diseases of the central nervous system. To address this problem we developed and experimentally validated a new computational approach to drug target ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b819cee406e6e53b3e29c211f519bf

Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis

Autor: Manuela Mazzuferi, Manuel Deprez, Bernard Rogister, Julie Crevecoeur, Catherine Vandenplas, Jérôme Kroonen, M Neveux, Patrik Foerch, Christophe Poulet, Gustave Moonen, Henrik Klitgaard, Estelle Rikir, Didier Martin, RM Kaminski, Bernard Sadzot

Publikováno v: Neuropathology and Applied Neurobiology. 40:191-204

Aims Synaptic vesicle proteins 2 (SV2) are neuronal vesicles membrane glycoproteins that appear as important targets in the treatment of partial and generalized epilepsies. Therefore, we analysed the expression of SV2 isoforms in the hippocampus of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53098e9cf8798d9e92db3f59cef289b0
https://doi.org/10.1111/nan.12054

Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization

Autor: Rafal M. Kaminski, Gaurav Kumar, Manuela Mazzuferi, Chiara Carla Rospo

Publikováno v: Experimental Neurology. 238:156-167

Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy and several rodent models allow studying the pathophysiology of this disorder. One of the best characterized models of TLE is the pilocarpine model. The model has been wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6522dbbb7dcae20f65f88875acddcca
https://doi.org/10.1016/j.expneurol.2012.08.022

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

Autor: Bénédicte Danis, Alessia Visconti, Owen J. L. Rackham, Alexander Grote, Christoph Helmstaedter, Blair H. Smith, Gail Davies, Caroline Hayward, Anaïs Katz, Kirill Shkura, Sandosh Padmanabhan, Rafal M. Kaminski, Aida Moreno-Moral, Andrée Delahaye-Duriez, David J. Porteous, Tiziana Rossetti, Albert J. Becker, W. David Hill, Lynne J. Hocking, Mario Falchi, Leonardo Bottolo, Ian J. Deary, Patrik Foerch, Marvin Johnson, Prashant K. Srivastava, David C. Liewald, John M. Starr, Sarah R. Langley, Manuela Mazzuferi, Maxime Rotival, Enrico Petretto, Doug Speed, Slavé Petrovski, Sarah E. Harris

Publikováno v: Johnson, M R, Shkura, K, Langley, S R, Delahaye-Duriez, A, Srivastava, P, Hill, W D, Rackham, O J L, Davies, G, Harris, S E, Moreno-Moral, A, Rotival, M, Speed, D, Petrovski, S, Katz, A, Hayward, C, Porteous, D J, Smith, B H, Padmanabhan, S, Hocking, L J, Starr, J M, Liewald, D C, Visconti, A, Falchi, M, Bottolo, L, Rossetti, T, Danis, B, Mazzuferi, M, Foerch, P, Grote, A, Helmstaedter, C, Becker, A J, Kaminski, R M, Deary, I J & Petretto, E 2016, ' Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease ', Nature Neuroscience, vol. 19, no. 2, pp. 223-232 . https://doi.org/10.1038/nn.4205

Genetic determinants of cognition are poorly characterized, and their relationship to genes that confer risk for neurodevelopmental disease is unclear. Here we performed a systems-level analysis of genome-wide gene expression data to infer gene-regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d64bd386720ed88c365f3e5533794b3
https://www.pure.ed.ac.uk/ws/files/26339468/imperial_man.pdf