The polyphenol/saponin-rich Rhus tripartita extract has an apoptotic effect on THP-1 cells through the PI3K/AKT/mTOR signaling pathway

Autor: Hajer Tlili, Anca Macovei, Daniela Buonocore, Manuela Lanzafame, Hanen Najjaa, Anita Lombardi, Andrea Pagano, Maurizia Dossena, Manuela Verri, Abdelkarim Ben Arfa, Mohamed Neffati, Enrico Doria

Publikováno v: BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-13 (2021)

Abstract Background Hyperactivation of mechanistic target of rapamycin (mTOR) signaling pathway is involved in the regulation of cellular growth, proliferation, and more in general, is a common phenomenon in most types of cancers. Thus, natural subst

Externí odkaz: https://doaj.org/article/89b77a523e07455ba760e6ee0c3e21ba

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

Autor: Manuela Lanzafame, Gaia Bianco, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 3, p 682 (2018)

Whole-transcriptome analyses have revealed that a large proportion of the human genome is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs (lncRNAs). Rather than being “transcriptional noise”, increasing evidence

Externí odkaz: https://doaj.org/article/2ead261ae53844e9a975068a91cf287f

Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma

Autor: Bernhard Englinger, Salvatore Piscuoglio, Jean Rommelaere, Dominik Witzigmann, Sushilla van Schoonhoven, Walter Berger, David Grünig, Xue-Ting Tran, Patrick Hauswirth, Susanne H. Schenk, Stephan Krähenbühl, Jörg Huwyler, Luigi Terracciano, Manuela Lanzafame, Philip Grossen, Cristina Quintavalle, Jürg P. F. Nüesch, Luca Quagliata

Publikováno v: Journal of Controlled Release. 334:138-152

Hepatocellular carcinoma (HCC) is related to increasing incidence rates and poor clinical outcomes due to lack of efficient treatment options and emerging resistance mechanisms. The aim of the present study is to exploit a non-viral gene therapy enab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bad076640ca4aef3965956cab86bff0
https://doi.org/10.1016/j.jconrel.2021.04.023

Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens

Autor: Salvatore Piscuoglio, Stephanie Taha-Mehlitz, Antoine de Weck, Hesam Montazeri, Manuela Lanzafame, Sumana Srivatsa, Viola Paradiso, Guglielmo Roma, Charlotte K.Y. Ng, Ehsan Zangene, Niko Beerenwinkel, Gaia Bianco, Luigi Terracciano, Mairene Coto-Llerena, Markus von Flüe, Martin Bolli

Publikováno v: Nucleic Acids Research, 49 (15)
Montazeri, Hesam; Coto-Llerena, Mairene; Bianco, Gaia; Zangene, Ehsan; Taha-Mehlitz, Stephanie; Paradiso, Viola; Srivatsa, Sumana; de Weck, Antoine; Roma, Guglielmo; Lanzafame, Manuela; Bolli, Martin; Beerenwinkel, Niko; von Flüe, Markus; Terracciano, Luigi M; Piscuoglio, Salvatore; Ng, Charlotte K Y (2021). Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens. Nucleic acids research, 49(15), pp. 8488-8504. Oxford University Press 10.1093/nar/gkab627
Nucleic Acids Research

BackgroundSystematic perturbation screens provide comprehensive resources for the elucidation of cancer driver genes, including rarely mutated genes that are missed by approaches focused on frequently mutated genes and driver genes for which the basi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea8828b498526269a1316bc3a3ec366

Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation

Autor: Ana Luísa Correia, Alexander Schmidt, Mihaela Zavolan, Joao C. Guimaraes, Anastasiya Börsch, Sébastien Pfeffer, Luigi Terracciano, Gunter Meister, Salvatore Piscuoglio, Thomas Montavon, Souvik Ghosh, Johannes Danner, Nitish Mittal, Beatrice Dimitriades, Afzal Pasha Syed, Shreemoyee Ghosh, Manuela Lanzafame

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (18), ⟨10.15252/embj.2019103922⟩
The EMBO Journal

Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein‐level modulation. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47e999d1f62c666eb1f8b17ba27ab32
https://hal.archives-ouvertes.fr/hal-02954154/document