Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Manuela Jaklin"'
Autor:
Johann Röhrl, Maria-Riera Piqué-Borràs, Manuela Jaklin, Markus Werner, Oliver Werz, Heinke Josef, Hubert Hölz, Aldo Ammendola, Gerald Künstle
Publikováno v:
Plants, Vol 12, Iss 6, p 1348 (2023)
Arnica montana is well known for its anti-inflammatory properties. While the anti-inflammatory activity of Arnica flowers (Arnicae flos) has been extensively studied, that of the whole plant (Arnicae planta tota) is less characterized. We compared th
Externí odkaz:
https://doaj.org/article/fbf4984b279641ed8810309dca72a1e8
Autor:
Manuela Jaklin, Nicole Clemann, Marcel Leist, Paul Barrow, Stefan Kustermann, Jitao David Zhang, Martin Ebeling
Publikováno v:
Reproductive Toxicology. 98:286-298
Human induced pluripotent stem cells (hiPSC) were used to develop an assay format that may deliver information on teratogenicity of drugs. A human pluripotent stem cell scorecard panel was used to monitor the expression of 96 marker genes that are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a724ed9e847601e6e120e459059e69
https://doi.org/10.1016/j.reprotox.2020.10.011
https://doi.org/10.1016/j.reprotox.2020.10.011
Autor:
Manuela Jaklin, Claudia McGinnis, Erich Kueng, Paul Barrow, Lisa Sach-Peltason, Marcel Leist, Stefan Kustermann, Jitao David Zhang, Nicole Schaefer, Nicole Clemann
Publikováno v:
Toxicological Sciences
Teratogenicity poses severe threats to patient safety. Stem-cell-based in vitro systems are promising tools to predict human teratogenicity. However, current in vitro assays are limited because they either capture effects on a certain germ layer, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb95219af3a197bc5805d486b9c288ab
https://doi.org/10.1101/2021.07.06.451364
https://doi.org/10.1101/2021.07.06.451364
Autor:
Manuela Jaklin, Naomi Moris, Alfonso Martinez Arias, Veronika Mantziou, Stefan Kustermann, Peter Baillie-Benson
Pharmaceuticals that are intended for use in patients of childbearing potential need to be tested for teratogenicity before marketing. Several pharmaceutical companies use animal-free in vitro models which allow a more rapid selection of lead compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50ab59d11b10a3d93154364e5922b71e
https://doi.org/10.1101/2021.03.30.437698
https://doi.org/10.1101/2021.03.30.437698
Autor:
Stefan Kustermann, Manuela Jaklin, Peter Baillie-Benson, Veronika Mantziou, Alfonso Martinez Arias, Naomi Moris
Publikováno v:
Reproductive Toxicology (Elmsford, N.y.)
Highlights • Gastruloids are a new in vitro platform for teratogenicity testing. • Teratogens disrupt gastruloid gene expression and morphology with imaging readout. • Medium-throughput gastruloid cultures are quantifiable with statistical robu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cf1b134dc9480f0b0e2fbc3a212015
http://hdl.handle.net/10230/52710
http://hdl.handle.net/10230/52710