Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Manuela Ecker"'
Autor:
Manuela Ecker, Richard Schregle, Natasha Kapoor-Kaushik, Pascal Rossatti, Verena M Betzler, Daryan Kempe, Maté Biro, Nicholas Ariotti, Gregory MI Redpath, Jeremie Rossy
Publikováno v:
eLife, Vol 11 (2022)
T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of activated T cells. While the role of TCR clustering in
Externí odkaz:
https://doaj.org/article/9fa3ef129084483c9e4e569334eb2288
Autor:
Gregory M. I. Redpath, Manuela Ecker, Natasha Kapoor-Kaushik, Haig Vartoukian, Michael Carnell, Daryan Kempe, Maté Biro, Nicholas Ariotti, Jérémie Rossy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Internalized receptors are recycled back to the cell surface, but their precise mechanisms are unclear. Here, the authors show that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positiv
Externí odkaz:
https://doaj.org/article/7a443cee32e1488c8af56115215e2eb5
Autor:
Ewoud B. Compeer, Felix Kraus, Manuela Ecker, Gregory Redpath, Mayan Amiezer, Nils Rother, Philip R. Nicovich, Natasha Kapoor-Kaushik, Qiji Deng, Guerric P. B. Samson, Zhengmin Yang, Jieqiong Lou, Michael Carnell, Haig Vartoukian, Katharina Gaus, Jérémie Rossy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear. Here the authors follow TCR and show that a mobile endocytic network
Externí odkaz:
https://doaj.org/article/5315f8de18a145b38208d17d8b1c2fbf
Autor:
Pascal Rossatti, Luca Ziegler, Richard Schregle, Verena M Betzler, Manuela Ecker, Jérémie Rossy
Publikováno v:
Cells, Vol 8, Iss 11, p 1388 (2019)
T cell activation is immediately followed by internalization of the T cell receptor (TCR). TCR endocytosis is required for T cell activation, but the mechanisms supporting removal of TCR from the cell surface remain incompletely understood. Here we r
Externí odkaz:
https://doaj.org/article/fba9da09679d4992b3eab52372ef8510
Autor:
Nicholas Hanuscheck, Carine Thalman, Micaela Domingues, Samantha Schmaul, Muthuraman Muthuraman, Florian Hetsch, Manuela Ecker, Heiko Endle, Mohammadsaleh Oshaghi, Gianvito Martino, Tanja Kuhlmann, Katarzyna Bozek, Tim van Beers, Stefan Bittner, Jakob von Engelhardt, Johannes Vogt, Christina Francisca Vogelaar, Frauke Zipp
Publikováno v:
Journal of Experimental Medicine. 219
Evidence is emerging that immune responses not only play a part in the central nervous system (CNS) in diseases but may also be relevant for healthy conditions. We discovered a major role for the interleukin-4 (IL-4)/IL-4 receptor alpha (IL-4Rα) sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cce99385aabc511d3fbdcdf2ed8975
https://doi.org/10.1084/jem.20211887
https://doi.org/10.1084/jem.20211887
Autor:
Bruce JW. Evans, Robert Yammouni, Fabrizio Zeri, Silvia Tavazzi, Giulia Carlotta Rizzo, Bo Lauenborg, Rasmus Hagenau, Amanda Wittendorf, Manuela Eckert Andersen, Dimple Shah, Natalia Vlasak
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40137- (2024)
Trial design: Double-masked crossover RCT (Research Registry: #8136) comparison of a new HOYA one-day disposable multifocal contact lens (HOMCL) with Alcon DAILIES TOTAL1® Multifocal (ADT1). Methods: Sixty presbyopic participants from three countrie
Externí odkaz:
https://doaj.org/article/575c33c9f7504180b318912556b337ae
Autor:
Manuela Ecker, Richard Schregle, Natasha Kapoor-Kaushik, Pascal Rossatti, Verena M Betzler, Daryan Kempe, Maté Biro, Nicholas Ariotti, Gregory MI Redpath, Jeremie Rossy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06155b8adaffa79d2d212dca0aff23b0
https://doi.org/10.7554/elife.67550.sa2
https://doi.org/10.7554/elife.67550.sa2
Autor:
Manuela Ecker, Richard Schregle, Natasha Kapoor-Kaushik, Pascal Rossatti, Verena M Betzler, Daryan Kempe, Maté Biro, Nicholas Ariotti, Gregory MI Redpath, Jeremie Rossy
Publikováno v:
eLife
eLife, Vol 11 (2022)
eLife, Vol 11 (2022)
T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of activated T cells. While the role of TCR clustering in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::394fddd7680054f32036a3d04bb21119
https://pubmed.ncbi.nlm.nih.gov/35050850
https://pubmed.ncbi.nlm.nih.gov/35050850
Publikováno v:
Molecular Biology of the Cell
Endocytic trafficking controls the density of molecules at the plasma membrane and by doing so, the cell surface profile, which in turn determines how cells interact with their environment. A full apprehension of any cellular process necessitates und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0de6e45024774488017f51094f1d03
Autor:
Natasha Kapoor-Kaushik, Daryan Kempe, Haig Vartoukian, Jérémie Rossy, Nicholas Ariotti, Gregory M. I. Redpath, Manuela Ecker, Michael Carnell, Maté Biro
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The targeted endocytic recycling of the T cell receptor (TCR) to the immunological synapse is essential for T cell activation. Despite this, the mechanisms that underlie the sorting of internalised receptors into recycling endosomes remain poorly und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb8d7e1eee810cdeb5d52e7642fb379