Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Manuela Currao"'
Autor:
Christian A. Di Buduo, Manuela Currao, Alessandro Pecci, David L. Kaplan, Carlo L. Balduini, Alessandra Balduini
Publikováno v:
Haematologica, Vol 101, Iss 12 (2016)
Eltrombopag is a small, non-peptide thrombopoietin mimetic that has been approved for increasing platelet count not only in immune thrombocytopenia and Hepatitis C virus-related thrombocytopenia, but also in aplastic anemia. Moreover, this drug is un
Externí odkaz:
https://doaj.org/article/71a981bbc84147998e8572ffd25f8554
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54723 (2013)
Romiplostim (AMG531) is a Thrombopoietin (TPO) receptor agonist with no homology with the endogenous TPO that has been used to treat patients affected by immune thrombocytopenia (ITP). Despite the use of TPO mimetics in the clinical practice, the mec
Externí odkaz:
https://doaj.org/article/63c6e2e525624b22ab614fbec5eb5f88
Autor:
Alessandra Balduini, Christian Andrea Di Buduo, Alessandro Malara, Anna Lecchi, Paola Rebuzzini, Manuela Currao, Isabella Pallotta, Joseph A. Jakubowski, Marco Cattaneo
Publikováno v:
Haematologica, Vol 97, Iss 11 (2012)
Background The interaction of adenosine diphosphate with its P2Y1 and P2Y12 receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes.Design and Methods W
Externí odkaz:
https://doaj.org/article/59d53b63d88a40829f93546db5a197b1
Autor:
Alessandro Pecci, Christian A. Di Buduo, David L. Kaplan, Carlo L. Balduini, Manuela Currao, Alessandra Balduini
Publikováno v:
Haematologica. 101:1479-1488
Eltrombopag is a small, non-peptide thrombopoietin mimetic that has been approved for increasing platelet count not only in immune thrombocytopenia and Hepatitis C virus-related thrombocytopenia, but also in aplastic anemia. Moreover, this drug is un
Autor:
Christian A. Di Buduo, Manuela Currao, Lorenzo Tozzi, Vittorio Abbonante, Alessandro Malara, Alessandra Balduini
Publikováno v:
Cellular and Molecular Life Sciences. 72:1517-1536
Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday production and release of millions of platelets into the bloodstream. Since the discovery and cloning, in 1994, of their principal humoral factor, thrombopoietin, an
Autor:
Marco Cattaneo, Alessandra Balduini, Christian A. Di Buduo, Alessandro Malara, Anna Lecchi, Isabella Pallotta, Paola Rebuzzini, Manuela Currao, Joseph A. Jakubowski
Publikováno v:
Haematologica. 97:1657-1665
Background The interaction of adenosine diphosphate with its P2Y1 and P2Y12 receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes.Design and Methods W
Autor:
Christian A. Di Buduo, Vittorio Abbonante, Manuela Currao, Lorenzo Tozzi, Alessandra Balduini, Alessandro Malara
Hyaluronan (HA) is a glycosamminoglican involved in cell biology as well as a relevant polymer for tissue engineering and regenerative medicine. Megakaryocytes (Mks) are immersed in a mesh of extracellular matrix (ECM) components that regulate their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ad8214cf7e7d4dd5f6db3bd4532c64
https://europepmc.org/articles/PMC5071306/
https://europepmc.org/articles/PMC5071306/
Autor:
Andrea Peloso, Paolo Dionigi, Ilaria Benzoni, Massimo Abelli, Alessandro Malara, Carolina Bianco, Gaspari A, Jacopo Ferrario, Alessandra Balduini, Manuela Currao, Antonio Citro, Giuseppe Orlando, Marcello Maestri, Benedetta Maiga, Lorenzo Piemonti
Publikováno v:
Organogenesis
Kidney transplantation is the only potentially curative treatment for patient facing end-stage renal disease, and it is now routinely used. Its use is mainly limited by the supply of transplantable donor organs, which far exceeds the demand. Regenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a975dbc874684ac556ce0e25ee1b70
https://doi.org/10.1080/15476278.2015.1072661
https://doi.org/10.1080/15476278.2015.1072661
Autor:
Paquita Nurden, Eric Solary, William Vainchenker, Hana Raslova, Silverio Perrotta, Alessandra Balduini, Patrizia Noris, Guy Leverger, Najet Debili, Nathalie Balayn, Rémi Favier, Caroline Deswarte, Dominique Bluteau, Manuela Currao
Publikováno v:
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2014, 124 (2), pp.580-591. ⟨10.1172/JCI71861⟩
Europe PubMed Central
Journal of Clinical Investigation, 2014, 124 (2), pp.580-591. ⟨10.1172/JCI71861⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2014, 124 (2), pp.580-591. ⟨10.1172/JCI71861⟩
Europe PubMed Central
Journal of Clinical Investigation, 2014, 124 (2), pp.580-591. ⟨10.1172/JCI71861⟩
International audience; Point mutations in the 5′ UTR of ankyrin repeat domain 26 (ANKRD26) are associated with familial throm-bocytopenia 2 (THC2) and a predisposition to leukemia. Here, we identified underlying mechanisms of ANKRD26-associated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eefdcd3589935df7e507211e686c91c
https://hal.sorbonne-universite.fr/hal-01329310
https://hal.sorbonne-universite.fr/hal-01329310
Autor:
Gianluca Viarengo, David L. Kaplan, Manuela Currao, Chiara Buracchi, Cristian Gruppi, Alessandra Balduini, Giuseppe Celesti, Luigi Laghi, Alessandro Malara
Publikováno v:
Stem cells (Dayton, Ohio). 32(4)
Megakaryocytes associate with the bone marrow vasculature where they convert their cytoplasm into proplatelets that protrude through the vascular endothelium into the lumen and release platelets. The extracellular matrix (ECM) microenvironment plays