Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Manuela Calin"'
Autor:
Geanina Voicu, Cristina Ana Mocanu, Florentina Safciuc, Maria Anghelache, Mariana Deleanu, Sergiu Cecoltan, Mariana Pinteala, Cristina Mariana Uritu, Ionel Droc, Maya Simionescu, Ileana Manduteanu, Manuela Calin
Publikováno v:
Materials Today Bio, Vol 20, Iss , Pp 100620- (2023)
Runx2 is a key transcription factor involved in valvular interstitial cells (VIC) osteodifferentiation, a process actively entwined with the calcific aortic valve disease (CAVD). We hypothesize that a strategy intended to silence Runx2 could be a val
Externí odkaz:
https://doaj.org/article/53f5761dc0514927ade14d308f53a6ed
Publikováno v:
Nanomaterials, Vol 13, Iss 23, p 3015 (2023)
Cardiovascular diseases (CVD) is a general term for disorders affecting the heart or blood vessels and represent a major cause of disability and death worldwide [...]
Externí odkaz:
https://doaj.org/article/69668fe7b9854fae858df78237d534e8
Autor:
Irina Mihaela Pelin, Irina Popescu, Manuela Calin, Daniela Rebleanu, Geanina Voicu, Daniela Ionita, Marius-Mihai Zaharia, Marieta Constantin, Gheorghe Fundueanu
Publikováno v:
Gels, Vol 9, Iss 11, p 905 (2023)
Composite hydrogels containing apatite-like particles can act as scaffolds for osteoblast proliferation, with applications in bone tissue engineering. In this respect, porous biocompatible hydrogels were obtained from chitosan, oxidized pullulan, and
Externí odkaz:
https://doaj.org/article/8d43d6aa5c8d4d1e87c4e269b4079cdf
Autor:
Mirela-Fernanda Zaltariov, Mihaela Turtoi, Dragos Peptanariu, Ana-Maria Macsim, Lilia Clima, Corneliu Cojocaru, Nicoleta Vornicu, Bianca-Iulia Ciubotaru, Alexandra Bargan, Manuela Calin, Maria Cazacu
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2838 (2022)
Two chemical motifs of interest for medicinal chemistry, silatrane as 1-(3-aminopropyl) silatrane (SIL M), and nitro group attached in position 5 to salicylaldehyde, are coupled in a new structure, 1-(3-{[(2-hydroxy-5-nitrophenyl)methylidene]amino}pr
Externí odkaz:
https://doaj.org/article/83cb73ea234d45628b1e24dfe062d74b
Autor:
Mihaela Turtoi, Maria Anghelache, Andrei A. Patrascu, Mariana Deleanu, Geanina Voicu, Mihai Raduca, Florentina Safciuc, Ileana Manduteanu, Manuela Calin, Delia-Laura Popescu
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1217 (2022)
A wide variety of metal-based compounds have been obtained and studied for their antitumor activity since the intensely used cytostatic drugs (e.g., cisplatin) failed to accomplish their expected pharmacological properties. Thus, we aimed to develop
Externí odkaz:
https://doaj.org/article/ec3d112f135d4ca58feb573e773996ec
Autor:
Gheorghe Fundueanu, Marieta Constantin, Mihaela Turtoi, Sanda-Maria Bucatariu, Bogdan Cosman, Maria Anghelache, Geanina Voicu, Manuela Calin
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 865 (2022)
The cellular internalization of drug carriers occurs via different endocytic pathways that ultimately involve the endosomes and the lysosomes, organelles where the pH value drops to 6.0 and 5.0, respectively. We aimed to design and characterize pH/te
Externí odkaz:
https://doaj.org/article/abe49dddace44834a1404c391c2fca95
Autor:
Geanina Voicu, Daniela Rebleanu, Cristina Ana Mocanu, Gabriela Tanko, Ionel Droc, Cristina Mariana Uritu, Mariana Pinteala, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3824 (2022)
Calcific aortic valve disease (CAVD) is a progressive inflammatory disorder characterized by extracellular matrix remodeling and valvular interstitial cells (VIC) osteodifferentiation leading to valve leaflets calcification and impairment movement. R
Externí odkaz:
https://doaj.org/article/437ce64fb9ff45fabbb3622d58ba7be9
Autor:
Maria Anghelache, Mihaela Turtoi, Anca Roxana Petrovici, Adrian Fifere, Mariana Pinteala, Manuela Calin
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1414 (2021)
Vascular inflammation plays a crucial role in the progression of various pathologies, including atherosclerosis (AS), and thus it has become an attractive therapeutic target. The protocatechuic acid (PCA), one of the main metabolites of complex polyp
Externí odkaz:
https://doaj.org/article/1e46063cce3f4fa3a8e2cbb7856dfe26
Autor:
Mihaela Turtoi, Maria Anghelache, Andrei A. Patrascu, Catalin Maxim, Ileana Manduteanu, Manuela Calin, Delia-Laura Popescu
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 562 (2021)
Type 2 diabetes became an alarming global health issue since the existing drugs do not prevent its progression. Herein, we aimed to synthesize and characterize a family of oxidovanadium(V) complexes with Schiff base ligands derived from L-/D-valine (
Externí odkaz:
https://doaj.org/article/1078c18428c14dd0bb67f06f6691f0aa
Autor:
Elena Valeria Fuior, Cristina Ana Mocanu, Mariana Deleanu, Geanina Voicu, Maria Anghelache, Daniela Rebleanu, Maya Simionescu, Manuela Calin
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1066 (2020)
Naringenin, an anti-inflammatory citrus flavonoid, is restrained from large-scale use by its reduced water solubility and bioavailability. To overcome these limitations, naringenin was loaded into lipid nanoemulsions directed towards vascular cell ad
Externí odkaz:
https://doaj.org/article/d16072d8947a474daaf6d4ee6a00dbf6