Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Manuela, Völkner"'
Autor:
Madalena Carido, Manuela Völkner, Lisa Maria Steinheuer, Felix Wagner, Thomas Kurth, Natalie Dumler, Selen Ulusoy, Stephanie Wieneke, Anabel Villanueva Norniella, Cristina Golfieri, Shahryar Khattak, Bruno Schönfelder, Maria Scamozzi, Katja Zoschke, Sebastian Canzler, Jörg Hackermüller, Marius Ader, Mike O. Karl
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The possible applications for human retinal organoids (HROs) derived from human induced pluripotent stem cells (hiPSC) rely on the robustness and transferability of the methodology for their generation. Standardized strategies and parameters to effec
Externí odkaz:
https://doaj.org/article/11c92076dd06422d8dbd23b2ba307247
Autor:
Manuela Völkner, Felix Wagner, Lisa Maria Steinheuer, Madalena Carido, Thomas Kurth, Ali Yazbeck, Jana Schor, Stephanie Wieneke, Lynn J. A. Ebner, Claudia Del Toro Runzer, David Taborsky, Katja Zoschke, Marlen Vogt, Sebastian Canzler, Andreas Hermann, Shahryar Khattak, Jörg Hackermüller, Mike O. Karl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Complex neuropathologies, like macular degeneration, are common but incompletely understood. Here the authors report a complex human retina pathology organoid model induced by HBEGF-TNF, causing PIEZO1-mediated photoreceptor degeneration by cell extr
Externí odkaz:
https://doaj.org/article/30a2670f9c1c4f9abedd9ae8b2421fed
Autor:
Manuela Völkner, Felix Wagner, Thomas Kurth, Alex M. Sykes, Claudia Del Toro Runzer, Lynn J. A. Ebner, Cagri Kavak, Vasileia Ismini Alexaki, Peter Cimalla, Mirko Mehner, Edmund Koch, Mike O. Karl
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Neurodegenerative diseases remain incompletely understood and therapies are needed. Stem cell-derived organoid models facilitate fundamental and translational medicine research. However, to which extent differential neuronal and glial pathologic proc
Externí odkaz:
https://doaj.org/article/b6df85ddea224a268d9f688df0becab5
Autor:
Sylvia J. Gasparini, Karen Tessmer, Miriam Reh, Stephanie Wieneke, Madalena Carido, Manuela Völkner, Oliver Borsch, Anka Swiersy, Marta Zuzic, Olivier Goureau, Thomas Kurth, Volker Busskamp, Günther Zeck, Mike O. Karl, Marius Ader
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Once human photoreceptors die, they do not regenerate, thus, photoreceptor transplantation has emerged as a potential treatment approach for blinding diseases. Improvements in transplant organization, donor cell maturation, and synaptic connectivity
Externí odkaz:
https://doaj.org/article/fe4bf4e4232c467ab4736faa8c84bb59
Autor:
Manuela Völkner, Thomas Kurth, Jana Schor, Lynn J. A. Ebner, Lara Bardtke, Cagri Kavak, Jörg Hackermüller, Mike O. Karl
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Using retinal organoid systems, organ-like 3D tissues, relies implicitly on their robustness. However, essential key parameters, particularly retinal growth and longer-term culture, are still insufficiently defined. Here, we hypothesize that a previo
Externí odkaz:
https://doaj.org/article/286a71147cf540468eb701d7fc0128cf
Autor:
Manuela Völkner, Marlen Zschätzsch, Maria Rostovskaya, Rupert W. Overall, Volker Busskamp, Konstantinos Anastassiadis, Mike O. Karl
Publikováno v:
Stem Cell Reports, Vol 6, Iss 4, Pp 525-538 (2016)
The plasticity of pluripotent stem cells provides new possibilities for studying development, degeneration, and regeneration. Protocols for the differentiation of retinal organoids from embryonic stem cells have been developed, which either recapitul
Externí odkaz:
https://doaj.org/article/e3aa552620084479a3c39ec0e2ee5f18
Autor:
Sylvia J. Gasparini, Karen Tessmer, Miriam Reh, Stephanie Wieneke, Madalena Carido, Manuela Völkner, Oliver Borsch, Anka Swiersy, Marta Zuzic, Olivier Goureau, Thomas Kurth, Volker Busskamp, Günther Zeck, Mike O. Karl, Marius Ader
Publikováno v:
J Clin Invest
Once human photoreceptors die, they do not regenerate, thus, photoreceptor transplantation has emerged as a potential treatment approach for blinding diseases. Improvements in transplant organization, donor cell maturation, and synaptic connectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c420e2b104708c56ab0bf37ac1f0f4b
https://pubmed.ncbi.nlm.nih.gov/35482419
https://pubmed.ncbi.nlm.nih.gov/35482419
Publikováno v:
Human gene therapy 32(13-14), 694-706 (2021). doi:10.1089/hum.2020.321
The most widely used vectors for gene delivery in the retina are recombinant adeno-associated virus (rAAV) vectors. They have proven to be safe and effective in retinal gene therapy studies aimed to treat inherited retinal dystrophies, although with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd5b5edb63c35559d72c59fb4d525a9
Autor:
Manuela Völkner, Felix Wagner, Lisa Maria Steinheuer, Madalena Carido, Thomas Kurth, Ali Yazbeck, Jana Schor, Stephanie Wieneke, Lynn J. A. Ebner, Claudia Del Toro Runzer, David Taborsky, Katja Zoschke, Marlen Vogt, Sebastian Canzler, Andreas Hermann, Shahryar Khattak, Jörg Hackermüller, Mike O. Karl
Publikováno v:
Nature Communications 13(1), 6183 (2022). doi:10.1038/s41467-022-33848-y
Human organoids could facilitate research of complex and currently incurable neuropathologies, such as age-related macular degeneration (AMD) which causes blindness. Here, we establish a human retinal organoid system reproducing several parameters of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db990db6d94b0c5a875b41b7c561426
https://pubmed.ncbi.nlm.nih.gov/36261438
https://pubmed.ncbi.nlm.nih.gov/36261438
Publikováno v:
Methods in Molecular Biology ISBN: 9781493986682
New York, NY : Springer New York, Methods in Molecular Biology 1834, 119-141 (2019). doi:10.1007/978-1-4939-8669-9_9
Retinal Degeneration / Weber, Bernhard H. F. (Editor) ; New York, NY : Springer New York, 2019, Chapter 9 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-8668-2=978-1-4939-8669-9 ; doi:10.1007/978-1-4939-8669-9
New York, NY : Springer New York, Methods in Molecular Biology 1834, 119-141 (2019). doi:10.1007/978-1-4939-8669-9_9
Retinal Degeneration / Weber, Bernhard H. F. (Editor) ; New York, NY : Springer New York, 2019, Chapter 9 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-8668-2=978-1-4939-8669-9 ; doi:10.1007/978-1-4939-8669-9
The introduction of stem cell-based technologies for the derivation of three-dimensional retinal tissues, the so-called retinal organoids, offers many new possibilities for vision research: Organoids facilitate studies on retinal development and in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3377d5f9ad41c69856a37e6cc964ed
https://doi.org/10.1007/978-1-4939-8669-9_9
https://doi.org/10.1007/978-1-4939-8669-9_9