Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Manuela, Platé"'
Autor:
Puja Mehta, Blanca Sanz-Magallón Duque de Estrada, Emma K. Denneny, Kane Foster, Carolin T. Turner, Andreas Mayer, Martina Milighetti, Manuela Platé, Kaylee B. Worlock, Masahiro Yoshida, Jeremy S. Brown, Marko Z. Nikolić, Benjamin M. Chain, Mahdad Noursadeghi, Rachel C. Chambers, Joanna C. Porter, Gillian S. Tomlinson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPersistent radiological lung abnormalities are evident in many survivors of acute coronavirus disease 2019 (COVID-19). Consolidation and ground glass opacities are interpreted to indicate subacute inflammation whereas reticulation is though
Externí odkaz:
https://doaj.org/article/0c20d7c4f93849d0869626a0bd37c791
Autor:
R Gisli Jenkins, A John Simpson, Nicholas D Weatherley, Guilhem Collier, Jim M Wild, David R Thickett, Shaney L Barratt, Nazia Chaudhuri, Ling-Pei Ho, Lisa G Spencer, John F Blaikley, Fasihul Khan, Iain Stewart, John Kenneth Baillie, Rod Lawson, Simon R Johnson, Paul Beirne, Mark Spears, Laura Fabbri, Joseph Jacob, Mark G Jones, Bibek Gooptu, Rachel C Chambers, Philip L Molyneaux, Peter M George, Michael A Gibbons, Emma K Denneny, Joanna C Porter, Manuela Platé, Stephen M Bianchi, Chris E Brightling, Richard James Allen, Annemarie Docherty, Jane A Mitchell, Ian P Hall, Jonathan Brooke, Louise V Wain, Malcolm Semple, Raminder Aul, Neil A Hanley, Krisnah Poinasamy, Pilar Rivera-Ortega, DJF Smith, Stefan C Stanel, A A Roger Thompson, Simon LF Walsh, Mark Everard Weeks, Dan G Wootton, Karen Piper Hanley
Publikováno v:
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/5d520253a7b4481e90cf8d3281a60c82
Autor:
Iain Stewart, Joseph Jacob, Peter M. George, Philip L. Molyneaux, Joanna C. Porter, Richard J. Allen, Shahab Aslani, J. Kenneth Baillie, Shaney L. Barratt, Paul Beirne, Stephen M. Bianchi, John F. Blaikley, James D. Chalmers, Rachel C. Chambers, Nazia Chadhuri, Christopher Coleman, Guilhem Collier, Emma K. Denneny, Annemarie Docherty, Omer Elneima, Rachael A. Evans, Laura Fabbri, Michael A. Gibbons, Fergus V. Gleeson, Bibek Gooptu, Neil J. Greening, Beatriz Guillen Guio, Ian P. Hall, Neil A. Hanley, Victoria Harris, Ewen M. Harrison, Melissa Heightman, Toby E. Hillman, Alex Horsley, Linzy Houchen-Wolloff, Ian Jarrold, Simon R. Johnson, Mark G. Jones, Fasihul Khan, Rod Lawson, Olivia Leavy, Nazir Lone, Michael Marks, Hamish McAuley, Puja Mehta, Dhruv Parekh, Karen Piper Hanley, Manuela Platé, John Pearl, Krisnah Poinasamy, Jennifer K. Quint, Betty Raman, Matthew Richardson, Pilar Rivera-Ortega, Laura Saunders, Ruth Saunders, Malcolm G. Semple, Marco Sereno, Aarti Shikotra, A. John Simpson, Amisha Singapuri, David J. F. Smith, Mark Spears, Lisa G. Spencer, Stefan Stanel, David R. Thickett, A. A. Roger Thompson, Mathew Thorpe, Simon L. F. Walsh, Samantha Walker, Nicholas David Weatherley, Mark E. Weeks, Jim M. Wild, Dan G. Wootton, Chris E. Brightling, Ling-Pei Ho, Louise V. Wain, Gisli R. Jenkins
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 207:693-703
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibr
Externí odkaz:
https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
Publikováno v:
European Respiratory Review, Vol 29, Iss 157 (2020)
Idiopathic pulmonary fibrosis (IPF) is characterised by the progressive deposition of excessive extracellular matrix proteins within the lung parenchyma and represents the most rapidly progressive and fatal of all fibrotic conditions. Current anti-fi
Externí odkaz:
https://doaj.org/article/d492010206b4400eaed8950a5892a9c8
Publikováno v:
Breathe, Vol 15, Iss 2, Pp 128-130 (2019)
Externí odkaz:
https://doaj.org/article/a8d076ee79264577ae349b3e842a4a2d
Autor:
Puja Mehta, Blanca Sanz-Magallón Duque de Estrada, Emma K Denneny, Kane Foster, Carolin T Turner, Andreas Mayer, Martina Milighetti, Manuela Platé, Kaylee B Worlock, Masahiro Yoshida, Jeremy S Brown, Marko Z Nikolić, Arjun Nair, Benjamin M Chain, Mahdad Noursadeghi, Rachel C Chambers, Joanna C Porter, Gillian S Tomlinson
RationalePersistent pulmonary sequelae are evident in many survivors of acute coronavirus disease 2019 (COVID-19) but the molecular mechanisms responsible are incompletely understood. Post-COVID radiological lung abnormalities comprise two broad cate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a9a38043410cc595cc35362b5a61e02
https://doi.org/10.1101/2023.03.28.23287759
https://doi.org/10.1101/2023.03.28.23287759
Autor:
Iain, Stewart, Joseph, Jacob, Peter M, George, Philip L, Molyneaux, Joanna C, Porter, Richard J, Allen, Shahab, Aslani, J Kenneth, Baillie, Shaney L, Barratt, Paul, Beirne, Stephen M, Bianchi, John F, Blaikley, James D, Chalmers, Rachel C, Chambers, Nazia, Chaudhuri, Christopher, Coleman, Guilhem, Collier, Emma K, Denneny, Annemarie, Docherty, Omer, Elneima, Rachel A, Evans, Laura, Fabbri, Michael A, Gibbons, Fergus V, Gleeson, Bibek, Gooptu, Neil J, Greening, Beatriz, Guillen Guio, Ian P, Hall, Neil A, Hanley, Victoria, Harris, Ewen M, Harrison, Melissa, Heightman, Toby E, Hillman, Alex, Horsley, Linzy, Houchen-Wolloff, Ian, Jarrold, Simon R, Johnson, Mark G, Jones, Fasihul, Khan, Rod, Lawson, Olivia, Leavy, Nazir, Lone, Michael, Marks, Hamish, McAuley, Puja, Mehta, Dhruv, Parekh, Karen, Piper Hanley, Manuela, Platé, John, Pearl, Krisnah, Poinasamy, Jennifer K, Quint, Betty, Raman, Matthew, Richardson, Pilar, Rivera-Ortega, Laura, Saunders, Ruth, Saunders, Malcolm G, Semple, Marco, Sereno, Aarti, Shikotra, A John, Simpson, Amisha, Singapuri, David Jf, Smith, Mark, Spears, Lisa G, Spencer, Stefan, Stanel, David, Thickett, A A Roger, Thompson, Mathew, Thorpe, Simon Lf, Walsh, Samantha, Walker, Nicholas David, Weatherley, Mark, Weeks, Jim M, Wild, Dan G, Wootton, Chris E, Brightling, Ling-Pei, Ho, Louise V, Wain, R Gisli, Jenkins
Publikováno v:
Stewart, I, Jacob, J, George, P M, Molyneaux, P L, Porter, J C, Allen, R J, Aslani, S, Baillie, J K, Barratt, S L, Beirne, P, Bianchi, S M, Blaikley, J F, Chalmers, J D, Chambers, R C, Chaudhuri, N, Coleman, C, Collier, G, Denneny, E K, Docherty, A, Elneima, O, Evans, R A, Fabbri, L, Gibbons, M A, Gleeson, F V, Gooptu, B, Greening, N J, Guillen Guio, B, Hall, I P, Hanley, N A, Harris, V, Harrison, E M, Heightman, M, Hillman, T E, Horsley, A, Houchen-Wolloff, L, Jarrold, I, Johnson, S R, Jones, M G, Khan, F, Lawson, R, Leavy, O, Lone, N, Marks, M, McAuley, H, Mehta, P, Parekh, D, Piper Hanley, K, Platé, M, Pearl, J, Poinasamy, K, Quint, J K, Raman, B, Richardson, M, Rivera-Ortega, P, Saunders, L, Saunders, R, Semple, M G, Sereno, M, Shikotra, A, Simpson, A J, Singapuri, A, Smith, D J, Spears, M, Spencer, L G, Stanel, S, Thickett, D, Thompson, A A R, Thorpe, M, Walsh, S L, Walker, S, Weatherley, N D, Weeks, M, Wild, J M, Wootton, D G, Brightling, C E, Ho, L-P, Wain, L V & Jenkins, R G 2022, ' Residual Lung Abnormalities Following COVID-19 Hospitalization : Interim Analysis of the UKILD Post-COVID Study ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.202203-0564OC
RATIONALE: Shared symptoms and genetic architecture between COVID-19 and lung fibrosis suggests SARS-CoV-2 infection may lead to progressive lung damage.OBJECTIVES: The UKILD Post-COVID study interim analysis was planned to estimate the prevalence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::895e907deebf37eb0f0a413c19a07912
https://www.pure.ed.ac.uk/ws/files/312743012/rccm.202203_0564oc.pdf
https://www.pure.ed.ac.uk/ws/files/312743012/rccm.202203_0564oc.pdf
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/35a6295d2586420286eccc316b713105
Autor:
Jennifer Rynne, Elena Ortiz-Zapater, Paniz Khooshemehri, Nicole O. Ponde, Giselda Bucca, Andrew Hesketh, Manuela Platé, Rachel Chambers, Colin Smith, Rocio T. Martinez-Nunez
Glucocorticoids (GCs) are one of the most used anti-inflammatory drugs worldwide. Despite their widespread use, our understanding of their post-transcriptional effects remains poorly understood. The tristetraprolin (TTP) RNA binding protein (RBP) fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ffd508aa9a1b101852bfb12272e0459
https://doi.org/10.1101/2022.09.27.509553
https://doi.org/10.1101/2022.09.27.509553