Declines in prevalence alter the optimal level of sexual investment for the malaria parasite

Autor: Angela M, Early, Flavia, Camponovo, Stéphane, Pelleau, Gustavo C, Cerqueira, Yassamine, Lazrek, Béatrice, Volney, Manuela, Carrasquilla, Benoît, de Thoisy, Caroline O, Buckee, Lauren M, Childs, Lise, Musset, Daniel E, Neafsey

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(30)

Successful infectious disease interventions can result in large reductions in parasite prevalence. Such demographic change has fitness implications for individual parasites and may shift the parasite's optimal life history strategy. Here, we explore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ef8d2abc556bf850a7910a0c7521ca0
https://pubmed.ncbi.nlm.nih.gov/35867831

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Autor: Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V Avery, Vicky M Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E Boucher, Fabrice F Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L Colon, Daisy D Colón-López, Yolanda Corbett, Gregory J Crowther, Noemi Cowan, Sarah D'Alessandro, Na Le Dang, Michael Delves, Joseph L DeRisi, Alan Y Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T Ferdig, José A Fernández Robledo, David A Fidock, Isabelle Florent, Patrick V T Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M Goldgof, Rajarshi Guha, W Armand Guiguemde, Nil Gural, R Kiplin Guy, Michael A E Hansen, Kirsten K Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T Jensen, Rays H Y Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P Kumar, Dennis E Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N Mfopa, Raj N Misra, Seunghyun Moon, John P Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J Quinn, Christopher A Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J Sullivan, William Sullivan, Sundari Suresh, Brian M Suzuki, Yo Suzuki, S Joshua Swamidass, Donatella Taramelli, Lauve R Y Tchokouaha, Anjo Theron, David Thomas, Kathryn F Tonissen, Simon Townson, Abhai K Tripathi, Valentin Trofimov, Kenneth O Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M Vinetz, Phat Voong Vinh, Hoan Vu, Nao-Aki Watanabe, Kate Weatherby, Pamela M White, Andrew F Wilks, Elizabeth A Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H A Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A Willis

Publikováno v: PLoS Pathogens, Vol 12, Iss 7, p e1005763 (2016)

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg

Externí odkaz: https://doaj.org/article/18b88a00726d44659ebd19c6f7c84d1b

Red blood cell tension protects against severe malaria in the Dantu blood group

Autor: Dominic P. Kwiatkowski, Yen-Chun Lin, Thomas N. Williams, Johnstone Makale, Alex Macharia, Julian C. Rayner, Benjamin J. Ravenhill, Wilfred Nyamu, Manuela Carrasquilla, Michael P. Weekes, Pietro Cicuta, Kirk A. Rockett, Alejandro Marin-Menendez, Jurij Kotar, Viola Introini, Metrine Tendwa, J. Alexandra Rowe, Silvia N. Kariuki

Publikováno v: Kariuki, S, Marin-Menendez, A, Introini, V, Ravenhill, B J, Lin, Y C, Macharia, A, Makale, J, Tendwa, M, Nyamu, W, Kotar, J, Carrasquilla, M, Rowe, A J, Rockett, K A, Kwiatkowski, D P, Weekes, M P, Cicuta, P, Williams, T N & Rayner, J C 2020, ' Red blood cell tension protects against severe malaria in the Dantu blood group ', Nature, vol. 585, no. 7826, pp. 579-583 . https://doi.org/10.1038/s41586-020-2726-6
Nature

Malaria has had a major effect on the human genome, with many protective polymorphisms-such as the sickle-cell trait-having been selected to high frequencies in malaria-endemic regions1,2. The blood group variant Dantu provides 74% protection against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19654963f2d00c404ce3c5e3ff314214