Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Manuel van Gijsel-Bonnello"'
Autor:
Manuel van Gijsel-Bonnello, Kévin Baranger, Philippe Benech, Santiago Rivera, Michel Khrestchatisky, Max de Reggi, Bouchra Gharib
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194586 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0175369.].
Externí odkaz:
https://doaj.org/article/8a7c6ee5233e41edb94d94df8749a8d8
Autor:
Manuel van Gijsel-Bonnello, Kévin Baranger, Philippe Benech, Santiago Rivera, Michel Khrestchatisky, Max de Reggi, Bouchra Gharib
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175369 (2017)
Astrocytes play critical roles in central nervous system homeostasis and support of neuronal function. A better knowledge of their response may both help understand the pathophysiology of Alzheimer's disease (AD) and implement new therapeutic strateg
Externí odkaz:
https://doaj.org/article/a1366b9dd1474a049497a19d32c84036
Autor:
Meriam Nefla, Manuel van Gijsel Bonnello, J. Simon C. Arthur, Nicola J. Darling, Philip Cohen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Salt Inducible Kinases (SIKs), of which there are 3 isoforms, are established to play roles in innate immunity, metabolic control and neuronal function, but their role in adaptive immunity is unknown. To address this gap, we used a combination of SIK
Autor:
Lorenzo Morè, Lucia Privitera, Philippa Perrett, Daniel D. Cooper, Manuel Van Gijsel Bonnello, J. Simon C. Arthur, Bruno G. Frenguelli
The transcription factor cAMP response element binding protein (CREB) is widely regarded as orchestrating the genomic response that underpins a range of physiological functions in the central nervous system, including learning and memory. Of the mean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8f766d9f84b8dd9bed3e7b6a7bbd63
http://wrap.warwick.ac.uk/168875/1/WRAP-CREB-serine-spatial-cognitive-flexibility-long-term-potentiation-22.pdf
http://wrap.warwick.ac.uk/168875/1/WRAP-CREB-serine-spatial-cognitive-flexibility-long-term-potentiation-22.pdf
Autor:
Manuel van Gijsel-Bonnello, Nicola J. Darling, Takashi Tanaka, Samuele Di Carmine, Francesco Marchesi, Sarah Thomson, Kristopher Clark, Mariola Kurowska-Stolarska, Henry J. McSorley, Philip Cohen, J. Simon C. Arthur
Publikováno v:
Journal of Biological Chemistry. 298:102644
Idiopathic pulmonary fibrosis is a progressive and normally fatal disease with limited treatment options. The tyrosine kinase inhibitor nintedanib has recently been approved for the treatment of idiopathic pulmonary fibrosis, and its effectiveness ha
Autor:
Tsvetana Petrova, Manuel van Gijsel-Bonnello, Kirsty F. Houslay, J. Simon C. Arthur, Shaista Naqvi
IL-23 is an IL-12 family cytokine that is important in promoting Th17 responses and has been strongly linked to autoimmunity and psoriasis. It is a heterodimeric cytokine made up of a p19 subunit unique to IL-23 and a p40 subunit that is shared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a369ae1a5d23825f4dce07083a2a20b2
https://doi.org/10.1101/2020.07.07.189142
https://doi.org/10.1101/2020.07.07.189142
Autor:
Santiago Rivera, Max de Reggi, Wassila Carpentier, Delphine Stephan, Kévin Baranger, Bouchra Gharib, Manuel van Gijsel-Bonnello, Michel Khrestchatisky, Philippe Benech
Publikováno v:
Neurotherapeutics
Neurotherapeutics, 2019, ⟨10.1007/s13311-019-00754-z⟩
Neurotherapeutics, Springer Verlag, 2019, ⟨10.1007/s13311-019-00754-z⟩
Neurotherapeutics, 2019, ⟨10.1007/s13311-019-00754-z⟩
Neurotherapeutics, Springer Verlag, 2019, ⟨10.1007/s13311-019-00754-z⟩
The low-molecular weight thiol pantethine, known as a hypolipidemic and hypocholesterolemic agent, is the major precursor of co-enzyme A. We have previously shown that pantethine treatment reduces amyloid-β (Aβ)-induced IL-1β release and alleviate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816d9d8dd461de7cc8a2ae198fc05d4d
https://hal.science/hal-02339537
https://hal.science/hal-02339537
Autor:
Michel Khrestchatisky, Yves Molino, Max de Reggi, Lionel Bretillon, Bouchra Gharib, Niyazi Acar, Manuel van Gijsel-Bonnello
Publikováno v:
Journal of Cellular Physiology. 230:2415-2425
Pantethine, a natural low-molecular-weight thiol, shows broad activity in a large range of essential cellular pathways. It has been long known as a hypolipidemic and hypocholesterolemic agent. We showed recently that it exerts a neuroprotective actio
Autor:
Silvia Gaggero, Jonathan Martinez-Fabregas, Adeline Cozzani, Paul K. Fyfe, Malo Leprohon, Jie Yang, F. Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G. Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff-Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra
Publikováno v:
Gaggero, S, Martinez-Fabregas, J, Cozzani, A, Fyfe, P K, Leprohon, M, Yang, J, Thomasen, F E, Winkelmann, H, Magnez, R, Conti, A G, Wilmes, S, Pohler, E, van Gijsel Bonnello, M, Thuru, X, Quesnel, B, Soncin, F, Piehler, J, Lindorff-Larsen, K, Roychoudhuri, R, Moraga, I & Mitra, S 2022, ' IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein ', Science immunology, vol. 7, no. 78, eade5686 . https://doi.org/10.1126/sciimmunol.ade5686
Cytokines interact with their receptors in the extracellular space to control immune responses. How the physicochemical properties of the extracellular space influence cytokine signaling is incompletely elucidated. Here, we show that the activity of