Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Manuel Zancanella"'
Autor:
Gwenaella Rescourio, Ana Z. Gonzalez, Salman Jabri, Brian Belmontes, Gordon Moody, Doug Whittington, Xin Huang, Sean Caenepeel, Mario Cardozo, Alan C. Cheng, David Chow, Hannah Dou, Adrie Jones, Ron C. Kelly, Yihong Li, Mike Lizarzaburu, Mei-Chu Lo, Rommel Mallari, Cesar Meleza, Yosup Rew, Scott Simonovich, Daqing Sun, Simon Turcotte, Xuelei Yan, Simon G. Wong, Evelyn Yanez, Manuel Zancanella, Jonathan Houze, Julio C. Medina, Paul E. Hughes, Sean P. Brown
Publikováno v:
Journal of Medicinal Chemistry. 62:10258-10271
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of tumors. Herein, we report our efforts towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e56bfd1df312774368ff5b90efcd7cc
https://doi.org/10.1021/acs.jmedchem.9b01310
https://doi.org/10.1021/acs.jmedchem.9b01310
Autor:
Jia-Nan Gong, Angela Coxon, Sean Caenepeel, Cyril H. Benes, Andrew W. Roberts, Tao Osgood, Donia M Moujalled, Elaina Cajulis, Andrew H. Wei, Regina K. Egan, Mario G. Cardozo, Pedro J. Beltran, Liusheng Zhu, Marc Vimolratana, Sean P. Brown, Brian Lucas, Xin Huang, Gordon Moody, Paul E. Hughes, David C.S. Huang, Giovanna Pomilio, Joshua Taygerly, Jan Sun, Danny Chui, Leszek Poppe, Jude Canon, Douglas A. Whittington, Yunxiao Li, Manuel Zancanella, Nick A. Paras, Joseph McClanaghan, Xianghong Wang, Alan C. Cheng, Kathleen S. Keegan, Jonathan B. Houze, Leah J. Damon, Patricia Greninger, Brian Belmontes
Publikováno v:
Cancer discovery. 8(12)
The prosurvival BCL2 family member MCL1 is frequently dysregulated in cancer. To overcome the significant challenges associated with inhibition of MCL1 protein–protein interactions, we rigorously applied small-molecule conformational restriction, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecf4086e51963a2ef56014b0508efb2
https://pubmed.ncbi.nlm.nih.gov/31262746
https://pubmed.ncbi.nlm.nih.gov/31262746
Autor:
Piotr Cieplak, Gil Ma, Robyn D. Richardson, Jeffrey W. Smith, Yatsandra Oyola, Daniel Romo, Lynn M. Knowles, Manuel Zancanella
Publikováno v:
Journal of Medicinal Chemistry. 51:5285-5296
Fatty acid synthase (FAS) is necessary for growth and survival of tumor cells and is a promising drug target for oncology. Here, we report on the syntheses and activity of novel inhibitors of the thioesterase domain of FAS. Using the structure of orl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b93b81e7103276befde7f96e17e3c82
https://doi.org/10.1021/jm800321h
https://doi.org/10.1021/jm800321h
Autor:
Manuel Zancanella, Daniel Romo
Publikováno v:
Organic Letters. 10:3685-3688
A facile synthesis of the trans-fused azabicyclo[3.3.0]octane core of palau'amine and related pyrrole-imidazole alkaloids is described. Following gamma-lactam cleavage with concomitant epimerization at C12 of a previously reported tricycle, a facile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170293ea3bf1db751cda011e1ee8ca6b
https://doi.org/10.1021/ol801289b
https://doi.org/10.1021/ol801289b
Autor:
Rodney P. Feazell, John Brannon Gary, Jason A. Kautz, Kevin K. Klausmeyer, Ching Wah Wong, Manuel Zancanella
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 60:m532-m534
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d664df304c93e7401fc9c0bec87bd823
https://doi.org/10.1107/s1600536804006701
https://doi.org/10.1107/s1600536804006701
Publikováno v:
ChemInform. 42
The pyrrole-2-aminoimidazole (P-2-AI) alkaloids are a growing family of marine alkaloids, now numbering well over 150 members, with high topographical and biological information content. Their intriguing structural complexity, rich and compact stereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6253910729d28074d36259cf47495b06
https://doi.org/10.1002/chin.201147256
https://doi.org/10.1002/chin.201147256
Autor:
Daniel Romo, Jeffrey W. Smith, Gil Ma, Robyn D. Richardson, Yatsandra Oyola, Manuel Zancanella
Publikováno v:
Organic letters. 8(20)
Concise syntheses of orlistat (Xenical), a two-carbon transposed orlistat derivative, and valilactone are described that employ the tandem Mukaiyama aldol-lactonization (TMAL) process as a key step. This process allows facile modification of the alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d2dfb3f39fd049e1ea5bbe9a84b973
https://pubmed.ncbi.nlm.nih.gov/16986934
https://pubmed.ncbi.nlm.nih.gov/16986934
Autor:
Robyn D. Richardson, Gil Ma, Yatsandra Oyola, Manuel Zancanella, Lynn M. Knowles, Piotr Cieplak, Daniel Romo, Jeffrey W. Smith
Publikováno v:
Journal of Medicinal Chemistry; Jul2008, Vol. 51 Issue 17, p5285-5296, 12p