Blocking ATP-releasing channels prevents high extracellular ATP levels and airway hyperreactivity in an asthmatic mouse model

Autor: Génesis Vega, Susan B. Morris, Rebeca Benavente, Andrew J. Rasky, Mariana Ríos, Llilian Arzola Martínez, Wendy Fonseca, Manuel Villalón, Nicholas W. Lukacs

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 321(2)

Allergic asthma is a chronic airway inflammatory response to different triggers like inhaled allergens. Excessive ATP in fluids from patients with asthma is considered an inflammatory signal and an important autocrine/paracrine modulator of airway ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63184af537cee8b3d6def9356fc8549f
https://pubmed.ncbi.nlm.nih.gov/34231389

Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease

Autor: Anita Guequén, Ambra Gianotti, Llilian Arzola, Manuel Villalón, Carlos A. Flores, Marcus A. Mall, Luis J. V. Galietta, Amber R. Philp, Génesis Vega, Olga Zegarra-Moran

Publikováno v: JCI Insight
JCI Insight, Vol 5, Iss 16 (2020)

Airway mucociliary clearance (MCC) is the main mechanism of lung defense keeping airways free of infection and mucus obstruction. Airway surface liquid volume, ciliary beating, and mucus are central for proper MCC and critically regulated by sodium a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef48a9057a77f5c7c6ddff7b61fe9989
http://hdl.handle.net/11588/818326

An autocrine ATP release mechanism regulates basal ciliary activity in airway epithelium

Autor: Camilo Navarrete, Manuel Villalón, Karla Droguett, Daniela V Carreño, Nelson P. Barrera, Christian Fuentes, Mariana Ríos

Publikováno v: The Journal of Physiology. 595:4755-4767

Key points Extracellular ATP, in association with [Ca2+]i regulation, is required to maintain basal ciliary beat frequency. Increasing extracellular ATP levels increases ciliary beating in airway epithelial cells, maintaining a sustained response by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c55dadcfbe2e77ba43bff8ad51ab7c4
https://doi.org/10.1113/jp273996

Nitric oxide activation by progesterone suppresses ATP-induced ciliary activity in oviductal ciliated cells

Autor: Bredford Kerr, Karla Droguett, Manuel Villalón, Mariana Ríos

Publikováno v: Reproduction, fertility, and development. 30(12)

Ciliary beat frequency (CBF) regulates the oviductal transport of oocytes and embryos, which are important components of the reproductive process. Local release of ATP transiently increases CBF by increasing [Ca2+]i. Ovarian hormones also regulate ci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83021af7c995329898fa775fe6f7e9da
https://pubmed.ncbi.nlm.nih.gov/29936934

Concanavalin-A Induces Granulosa Cell Death and Inhibits FSH-Mediated Follicular Growth and Ovarian Maturation in Female Rats

Autor: Ricardo D. Moreno, Mariana Ríos, Anne Rokka, Dalhia Abramovich, Manuel Villalón, Marta Tesone, Barbara Oliva, Elizabeth Nuñez, Felipe Orge, Garry L. Corthals, M. E. Ortiz, Horacio B. Croxatto, Fernanda Parborell, Renan Orellana, Gareth I. Owen, Carlos Lizama, Ethel V. Velasquez

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
ENDOCRINOLOGY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Reproductive success stems from a finely regulated balance between follicular maturation and atresia, in which the role of carbohydrate structure is poorly understood. Here, we describe for the first time a fraction of purified recombinant human FSH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de64950146752ebc5d4b91ccdfb7ae2
https://doi.org/10.1210/en.2012-1945