Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Manuel Vázquez-Carrera"'
Autor:
Meijian Zhang, Emma Barroso, Lucía Peña, Patricia Rada, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117303- (2024)
The role of peroxisome proliferator-activated receptor (PPAR)β/δ in hepatic fibrosis remains a subject of debate. Here, we examined the effects of a PPARβ/δ agonist on the pathogenesis of liver fibrosis and the activation of hepatic stellate cell
Externí odkaz:
https://doaj.org/article/bd3f461a588d498c847ef3d9ba500e5e
Autor:
Mona Peyman, Anna Babin-Ebell, Rosalía Rodríguez-Rodríguez, Matilde Rigon, David Aguilar-Recarte, Joan Villarroya, Anna Planavila, Francesc Villarroya, Xavier Palomer, Emma Barroso, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR) promote hepatic steatosis by increasing the delivery of triglyceride-rich lipoproteins to the l
Externí odkaz:
https://doaj.org/article/aa50fcc0fdab48139a2c97688557bd98
Autor:
Emma Barroso, Marta Díaz, Ana Cristina Reguera, Mona Peyman, Jesús Balsinde, Javier Jurado-Aguilar, Meijian Zhang, Adel Rostami, Xavier Palomer, Lourdes Ibáñez, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background The placentas from newborns that are small for gestational age (SGA; birth weight
Externí odkaz:
https://doaj.org/article/0dde09ae81aa407db201bf013672fee5
Autor:
Mona Peyman, Emma Barroso, Andreea L. Turcu, Francesc Estrany, Jr., Dáire Smith, Javier Jurado-Aguilar, Patricia Rada, Christophe Morisseau, Bruce D. Hammock, Ángela M. Valverde, Xavier Palomer, Carles Galdeano, Santiago Vázquez, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115667- (2023)
Soluble epoxide hydrolase (sEH) is a drug target with the potential for therapeutic utility in the areas of inflammation, neurodegenerative disease, chronic pain, and diabetes, among others. Proteolysis-targeting chimeras (PROTACs) molecules offer ne
Externí odkaz:
https://doaj.org/article/5a58d1a50ea04ea4b20efc84ec133208
Autor:
Meijian Zhang, Emma Barroso, Maria Ruart, Lucía Peña, Mona Peyman, David Aguilar-Recarte, Marta Montori-Grau, Patricia Rada, Clara Cugat, Carla Montironi, Mohammad Zarei, Javier Jurado-Aguilar, Antoni Camins, Jesús Balsinde, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115623- (2023)
Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR)α and β/δ agonist that has reached a phase III clinical trial for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we examined the effec
Externí odkaz:
https://doaj.org/article/482a0be0b5064142a7d350a00b86da03
Autor:
Marta Montori-Grau, David Aguilar-Recarte, Mohammad Zarei, Javier Pizarro-Delgado, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) downregulation in skeletal muscle contributes to insulin resistance and type 2 diabetes mellitus. Here, we examined the effects of endoplasmic reticu
Externí odkaz:
https://doaj.org/article/451a5ea643dc4a84b44b5ac0d9421f14
Autor:
Meijian Zhang, Andrea Bagán, Donna Martínez, Emma Barroso, Xavier Palomer, Santiago Vázquez, Carmen Escolano, Manuel Vázquez-Carrera
Publikováno v:
Molecules, Vol 28, Iss 14, p 5468 (2023)
Targeting growth differentiation factor 15 (GDF15) is a recent strategy for the treatment of obesity and type 2 diabetes mellitus (T2DM). Here, we designed, synthesized, and pharmacologically evaluated in vitro a novel series of AMPK activators to up
Externí odkaz:
https://doaj.org/article/ed40fcf35d894d019b9ccc79b82ff181
Autor:
Triana Espinosa-Jiménez, Oriol Busquets, Amanda Cano, Elena Sánchez-López, Ester Verdaguer, Antoni Parcerisas, Jordi Olloquequi, Carme Auladell, Jaume Folch, Walter Wahli, Manuel Vázquez-Carrera, Antoni Camins, Miren Ettcheto
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the central nervous system, is involved in microglial homeostasis and metabolism, whose disturbances have been demonstrated to play a key role in memory i
Externí odkaz:
https://doaj.org/article/2721f1f916e94f66905ee7d3a6d12953
Autor:
Emma Barroso, Rosalía Rodríguez-Rodríguez, Mohammad Zarei, Javier Pizarro-Degado, Anna Planavila, Xavier Palomer, Francesc Villarroya, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we investigated additional mechanisms that mig
Externí odkaz:
https://doaj.org/article/1e71b226e6b349409edc0fa281f69201
Autor:
David Aguilar-Recarte, Emma Barroso, Anna Gumà, Javier Pizarro-Delgado, Lucía Peña, Maria Ruart, Xavier Palomer, Walter Wahli, Manuel Vázquez-Carrera
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109501- (2021)
Summary: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine whether PPARβ/δ activation effects depend on growth diffe
Externí odkaz:
https://doaj.org/article/b6f0fb8048d340e8be15dc85700ffd26