Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Manuel Vázquez-Carrera"'
Autor:
Mona Peyman, Anna Babin-Ebell, Rosalía Rodríguez-Rodríguez, Matilde Rigon, David Aguilar-Recarte, Joan Villarroya, Anna Planavila, Francesc Villarroya, Xavier Palomer, Emma Barroso, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR) promote hepatic steatosis by increasing the delivery of triglyceride-rich lipoproteins to the l
Externí odkaz:
https://doaj.org/article/aa50fcc0fdab48139a2c97688557bd98
Autor:
Emma Barroso, Marta Díaz, Ana Cristina Reguera, Mona Peyman, Jesús Balsinde, Javier Jurado-Aguilar, Meijian Zhang, Adel Rostami, Xavier Palomer, Lourdes Ibáñez, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background The placentas from newborns that are small for gestational age (SGA; birth weight
Externí odkaz:
https://doaj.org/article/0dde09ae81aa407db201bf013672fee5
Autor:
Marta Montori-Grau, David Aguilar-Recarte, Mohammad Zarei, Javier Pizarro-Delgado, Xavier Palomer, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) downregulation in skeletal muscle contributes to insulin resistance and type 2 diabetes mellitus. Here, we examined the effects of endoplasmic reticu
Externí odkaz:
https://doaj.org/article/451a5ea643dc4a84b44b5ac0d9421f14
Autor:
Meijian Zhang, Andrea Bagán, Donna Martínez, Emma Barroso, Xavier Palomer, Santiago Vázquez, Carmen Escolano, Manuel Vázquez-Carrera
Publikováno v:
Molecules, Vol 28, Iss 14, p 5468 (2023)
Targeting growth differentiation factor 15 (GDF15) is a recent strategy for the treatment of obesity and type 2 diabetes mellitus (T2DM). Here, we designed, synthesized, and pharmacologically evaluated in vitro a novel series of AMPK activators to up
Externí odkaz:
https://doaj.org/article/ed40fcf35d894d019b9ccc79b82ff181
Autor:
Triana Espinosa-Jiménez, Oriol Busquets, Amanda Cano, Elena Sánchez-López, Ester Verdaguer, Antoni Parcerisas, Jordi Olloquequi, Carme Auladell, Jaume Folch, Walter Wahli, Manuel Vázquez-Carrera, Antoni Camins, Miren Ettcheto
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the central nervous system, is involved in microglial homeostasis and metabolism, whose disturbances have been demonstrated to play a key role in memory i
Externí odkaz:
https://doaj.org/article/2721f1f916e94f66905ee7d3a6d12953
Autor:
Emma Barroso, Rosalía Rodríguez-Rodríguez, Mohammad Zarei, Javier Pizarro-Degado, Anna Planavila, Xavier Palomer, Francesc Villarroya, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we investigated additional mechanisms that mig
Externí odkaz:
https://doaj.org/article/1e71b226e6b349409edc0fa281f69201
Autor:
David Aguilar-Recarte, Emma Barroso, Anna Gumà, Javier Pizarro-Delgado, Lucía Peña, Maria Ruart, Xavier Palomer, Walter Wahli, Manuel Vázquez-Carrera
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109501- (2021)
Summary: Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine whether PPARβ/δ activation effects depend on growth diffe
Externí odkaz:
https://doaj.org/article/b6f0fb8048d340e8be15dc85700ffd26
Autor:
Ester Sala, Celia Vived, Júlia Luna, Noemí Alejandra Saavedra-Ávila, Upasana Sengupta, A. Raúl Castaño, Sabrina Villar-Pazos, Laura Haba, Joan Verdaguer, Ana B. Ropero, Thomas Stratmann, Javier Pizarro, Manuel Vázquez-Carrera, Angel Nadal, Jill M. Lahti, Conchi Mora
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundPancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependent Kinase 11) is downregulated by inflammation in
Externí odkaz:
https://doaj.org/article/43d700c8d29a47dc8cba0c3b8b15aa2f
Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
Autor:
Mohammad Zarei, Emma Barroso, Xavier Palomer, Jianli Dai, Patricia Rada, Tania Quesada-López, Joan Carles Escolà-Gil, Lidia Cedó, Mohammad Reza Zali, Mahsa Molaei, Reza Dabiri, Santiago Vázquez, Eugènia Pujol, Ángela M. Valverde, Francesc Villarroya, Yong Liu, Walter Wahli, Manuel Vázquez-Carrera
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 117-131 (2018)
Objective: The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated the role of Peroxisome Proliferator-Activated Receptor (PPAR)β/δ and fibroblast growth fact
Externí odkaz:
https://doaj.org/article/baf2dc9394c64f748472e1cdb91dd1a9
Publikováno v:
Trends in Endocrinology & Metabolism. 33:741-754
Although a large number of drugs are available for the treatment of type 2 diabetes mellitus (T2DM), many patients do not achieve adequate disease control despite adhering to medication. Recent findings indicate that the pharmacological modulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467196f960febc4eb58f4ae37fb0a526
https://doi.org/10.1016/j.tem.2022.08.004
https://doi.org/10.1016/j.tem.2022.08.004