Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Manuel Vázquez Carrera"'
Autor:
Adel Rostami, Xavier Palomer, Javier Pizarro-Delgado, Emma Barroso, Brenda Valenzuela-Alcaraz, Fátima Crispi, J. Francisco Nistal, María A. Hurlé, Raquel García, Walter Wahli, Manuel Vázquez-Carrera
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107515- (2024)
Diabetic cardiomyopathy (DCM) is a specific type of myocardial disease that often develops in patients suffering from diabetes, which has become the foremost cause of death among them. It is an insidious multifactorial disease caused by complex and p
Externí odkaz:
https://doaj.org/article/24b4094efce548fca931c15c675aa832
Autor:
Mona Peyman, Anna Babin-Ebell, Rosalía Rodríguez-Rodríguez, Matilde Rigon, David Aguilar-Recarte, Joan Villarroya, Anna Planavila, Francesc Villarroya, Xavier Palomer, Emma Barroso, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR) promote hepatic steatosis by increasing the delivery of triglyceride-rich lipoproteins to the l
Externí odkaz:
https://doaj.org/article/aa50fcc0fdab48139a2c97688557bd98
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 2, Pp 388-398 (2003)
Activation of nuclear factor-κB (NF-κB) is required for hypertrophic growth of cardiomyocytes. Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase I (CPT-I) that activates peroxisome proliferator-activated receptor α (PPARα) a
Externí odkaz:
https://doaj.org/article/181a12dee86c43af82fe64d310209ae0
Autor:
Emma Barroso, Marta Díaz, Ana Cristina Reguera, Mona Peyman, Jesús Balsinde, Javier Jurado-Aguilar, Meijian Zhang, Adel Rostami, Xavier Palomer, Lourdes Ibáñez, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background The placentas from newborns that are small for gestational age (SGA; birth weight
Externí odkaz:
https://doaj.org/article/0dde09ae81aa407db201bf013672fee5
Autor:
Meijian Zhang, Andrea Bagán, Donna Martínez, Emma Barroso, Xavier Palomer, Santiago Vázquez, Carmen Escolano, Manuel Vázquez-Carrera
Publikováno v:
Molecules, Vol 28, Iss 14, p 5468 (2023)
Targeting growth differentiation factor 15 (GDF15) is a recent strategy for the treatment of obesity and type 2 diabetes mellitus (T2DM). Here, we designed, synthesized, and pharmacologically evaluated in vitro a novel series of AMPK activators to up
Externí odkaz:
https://doaj.org/article/ed40fcf35d894d019b9ccc79b82ff181
Autor:
Triana Espinosa-Jiménez, Oriol Busquets, Amanda Cano, Elena Sánchez-López, Ester Verdaguer, Antoni Parcerisas, Jordi Olloquequi, Carme Auladell, Jaume Folch, Walter Wahli, Manuel Vázquez-Carrera, Antoni Camins, Miren Ettcheto
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the central nervous system, is involved in microglial homeostasis and metabolism, whose disturbances have been demonstrated to play a key role in memory i
Externí odkaz:
https://doaj.org/article/2721f1f916e94f66905ee7d3a6d12953
Autor:
Emma Barroso, Rosalía Rodríguez-Rodríguez, Mohammad Zarei, Javier Pizarro-Degado, Anna Planavila, Xavier Palomer, Francesc Villarroya, Manuel Vázquez-Carrera
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we investigated additional mechanisms that mig
Externí odkaz:
https://doaj.org/article/1e71b226e6b349409edc0fa281f69201
Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
Autor:
Mohammad Zarei, Emma Barroso, Xavier Palomer, Jianli Dai, Patricia Rada, Tania Quesada-López, Joan Carles Escolà-Gil, Lidia Cedó, Mohammad Reza Zali, Mahsa Molaei, Reza Dabiri, Santiago Vázquez, Eugènia Pujol, Ángela M. Valverde, Francesc Villarroya, Yong Liu, Walter Wahli, Manuel Vázquez-Carrera
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 117-131 (2018)
Objective: The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated the role of Peroxisome Proliferator-Activated Receptor (PPAR)β/δ and fibroblast growth fact
Externí odkaz:
https://doaj.org/article/baf2dc9394c64f748472e1cdb91dd1a9
Publikováno v:
Trends in Endocrinology & Metabolism. 33:741-754
Although a large number of drugs are available for the treatment of type 2 diabetes mellitus (T2DM), many patients do not achieve adequate disease control despite adhering to medication. Recent findings indicate that the pharmacological modulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467196f960febc4eb58f4ae37fb0a526
https://doi.org/10.1016/j.tem.2022.08.004
https://doi.org/10.1016/j.tem.2022.08.004
Publikováno v:
Trends in Pharmacological Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c7ec7e3e04fc73eb4a9e0d90ab4917
https://doi.org/10.1016/j.tips.2023.04.004
https://doi.org/10.1016/j.tips.2023.04.004