Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Manuel Torres Diz"'
1
Akademický článek
High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance
Autor: Mariela Cortés-López, Laura Schulz, Mihaela Enculescu, Claudia Paret, Bea Spiekermann, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Sebastian Unic, Anke Busch, Anna Orekhova, Monika Kuban, Mikhail Mesitov, Miriam M. Mulorz, Rawan Shraim, Fridolin Kielisch, Jörg Faber, Yoseph Barash, Andrei Thomas-Tikhonenko, Kathi Zarnack, Stefan Legewie, Julian König
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify
Externí odkaz: https://doaj.org/article/c08d347a8dc943b8ab905da6ad76b36d
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2
Akademický článek
Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts
Autor: Laura Schulz, Manuel Torres-Diz, Mariela Cortés-López, Katharina E. Hayer, Mukta Asnani, Sarah K. Tasian, Yoseph Barash, Elena Sotillo, Kathi Zarnack, Julian König, Andrei Thomas-Tikhonenko
Publikováno v: Genome Biology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing events, including recently reported excision of a cryptic intron embedded within CD19
Externí odkaz: https://doaj.org/article/7a025226aeea4eeeb954f32ea7752bb3
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6
Data from Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4–LEF1 Binding
Autor: Andrei Thomas-Tikhonenko, Struan F.A. Grant, James A. Pippin, Manuel Torres-Diz, Katharina Hayer, Priyanka Sehgal, Claudia B. Lanauze
About 10% to 30% of patients with colorectal cancer harbor either loss of or missense mutations in SMAD4, a critical component of the TGFβ signaling pathway. The pathophysiologic function of missense mutations in Smad4 is not fully understood. They
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98265ca73ce1e4a48df2705e6b56cac5
https://doi.org/10.1158/1541-7786.c.6545193.v1
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8
Data from MYC Hyperactivates Wnt Signaling in APC/CTNNB1-Mutated Colorectal Cancer Cells through miR-92a–Dependent Repression of DKK3
Autor: Andrei Thomas-Tikhonenko, Christopher J. Lengner, Ben Z. Stanger, Yogev Sela, N. Adrian Leu, Manuel Torres-Diz, Katharina E. Hayer, Xin Wang, Claudia Lanauze, Priyanka Sehgal
Activation of Wnt signaling is among the earliest events in colon cancer development. It is achieved either via activating mutations in the CTNNB1 gene encoding β-catenin, the key transcription factor in the Wnt pathway, or most commonly by inactiva
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9c4527f515cf88cde97282be383efb3
https://doi.org/10.1158/1541-7786.c.6544982.v1
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