Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Manuel Stucki"'
Autor:
Mara De Marco Zompit, Mònica Torres Esteban, Clémence Mooser, Salomé Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, Ann-Marie K. Shorrocks, Andrew N. Blackford, Daniel Durocher, Manuel Stucki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei formation and chromosomal instability.
Externí odkaz:
https://doaj.org/article/6bb76f98748d456bb28f51f91a387637
Autor:
Clémence Mooser, Ioanna-Eleni Symeonidou, Pia-Amata Leimbacher, Alison Ribeiro, Ann-Marie K. Shorrocks, Stephanie Jungmichel, Sara C. Larsen, Katja Knechtle, Arti Jasrotia, Diana Zurbriggen, Alain Jeanrenaud, Colin Leikauf, Daniel Fink, Michael L. Nielsen, Andrew N. Blackford, Manuel Stucki
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleol
Externí odkaz:
https://doaj.org/article/1e40f7a690df46ba8c9721ca498fe614
Publikováno v:
Reproductive Biology and Endocrinology, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor in
Externí odkaz:
https://doaj.org/article/7fb468786f1e482688ca6bc1b47c50ba
Autor:
Monica M. Olcina, Ryan K. Kim, Nikolas G. Balanis, Caiyun Grace Li, Rie von Eyben, Thomas G. Graeber, Daniel Ricklin, Manuel Stucki, Amato J. Giaccia
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101594- (2020)
Summary: The importance of innate immunity in cancer is increasingly being recognized with recent reports suggesting tumor cell-intrinsic intracellular functions for innate immunity proteins. However, such functions are often poorly understood, and i
Externí odkaz:
https://doaj.org/article/64c2b7db01984770a3fda8aeaa8c2c2f
Autor:
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Gabriel N Valbuena, Silvia Guglietta, Carsten Krieg, Damavandi Mahnaz Darvish, Tatsuya Suwa, Alistair Easton, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Albert C Koong, Trent M. Woodruff, Edward E. Graves, Tim Maughan, Simon J. A. Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J. Leedham, Amato J. Giaccia, Monica M Olcina
An immunosuppressive microenvironment causes poor tumour T-cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumours is still a challenge. Using an integrated s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067c11b230c8c3a656c28cd8e2962f11
https://doi.org/10.1101/2023.01.10.521547
https://doi.org/10.1101/2023.01.10.521547
Autor:
Nicole Hustedt, Henrique Melo, Dheva Setiaputra, Jessica Desjardins, Artur Veloso, Rachel K. Szilard, Shou Yun Yin, Alejandro Álvarez-Quilón, Michael Zinda, Timothy F. Ng, Meagan Munro, Robert Papp, Daniel Durocher, Mara De Marco Zompit, Yibo Xue, Giovanni Martino, Jordan T.F. Young, Nathalie Moatti, Salomé Adam, Natasha Chaudhary, Vivek Bhaskaran, Manuel Stucki, Sylvie M. Noordermeer, Toshiro K. Ohsumi, Silvia Emma Rossi
Publikováno v:
Nature Cancer, 2(12), 1357-+. NATURE PORTFOLIO
BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination (HR). Identification of these adaptive mechanisms may provide therapeutic strategies to target tumors caused by the loss of these gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9275bd317b6ceebb275c11ab3f1a0320
https://doi.org/10.5167/uzh-216678
https://doi.org/10.5167/uzh-216678
Autor:
Romana Koppensteiner, Eleftherios P Samartzis, Aurelia Noske, Adriana von Teichman, Ioannis Dedes, Myriam Gwerder, Patrick Imesch, Kristian Ikenberg, Holger Moch, Daniel Fink, Manuel Stucki, Konstantin J Dedes
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100041 (2014)
AIM OF THE STUDY:To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and to determine whether loss of MRE11 renders the cancer cells sensitive to Poly(ADP-ribose) polymerase (PARP)-inhibi
Externí odkaz:
https://doaj.org/article/e2b03d62fc24439bab61e7e592227dc6
Autor:
Silvia Emma Rossi, Henrique Melo, Michael Zinda, Veloso A, Bhaskaran, Desjardins J, Zompit Mdm, Timothy F. Ng, Papp R, Salomé Adam, Daniel Durocher, Nathalie Moatti, Alejandro Álvarez-Quilón, Sylvie M. Noordermeer, Meagan Munro, Yin Sy, Young Jt, Nicole Hustedt, Natasha Chaudhary, Rachel K. Szilard, Dheva Setiaputra, Martino G, Manuel Stucki, Ohsumi Tk
BRCA1/2-mutated cancer cells must adapt to the genome instability caused by their deficiency in homologous recombination. Identifying and targeting these adaptive mechanisms may provide new therapeutic strategies. Here we present the results of genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74faea63b60db263e7506b7972da4eb1
https://doi.org/10.1101/2021.02.08.430060
https://doi.org/10.1101/2021.02.08.430060
Autor:
Mooser C, Manuel Stucki, De Marco Zompit M, Daniel Fink, Daniel Durocher, Salomé Adam, Pia-Amata Leimbacher, Jeanrenaud A, Silvia Emma Rossi
The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB repair in favor of a tethering mechanism that stabilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f3a17add813095c14715c4c406bc135
https://doi.org/10.1101/2021.02.08.430274
https://doi.org/10.1101/2021.02.08.430274
Autor:
Mara, De Marco Zompit, Mònica Torres, Esteban, Clémence, Mooser, Salomé, Adam, Silvia Emma, Rossi, Alain, Jeanrenaud, Pia-Amata, Leimbacher, Daniel, Fink, Ann-Marie K, Shorrocks, Andrew N, Blackford, Daniel, Durocher, Manuel, Stucki
Publikováno v:
Nature communications. 13(1)
The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB repair in favor of a tethering mechanism that stabilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d80e0144914e61bb7229b5cad78c9085
https://pubmed.ncbi.nlm.nih.gov/35842428
https://pubmed.ncbi.nlm.nih.gov/35842428