Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Manuel Sánchez-Martin"'
Autor:
Tânia Albuquerque, Ana Raquel Neves, Milan Paul, Swati Biswas, Elena Vuelta, Ignacio García-Tuñón, Manuel Sánchez-Martin, Telma Quintela, Diana Costa
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 7, p 362 (2023)
The circadian clock controls behavior and physiology. Presently, there is clear evidence of a connection between this timing system and cancer development/progression. Moreover, circadian rhythm consideration in the therapeutic action of anticancer d
Externí odkaz:
https://doaj.org/article/f1614c48910e4ee1af46c4be82818902
Autor:
Higinio Dopeso, Paulo Rodrigues, Fernando Cartón-García, Irati Macaya, Josipa Bilic, Estefanía Anguita, Li Jing, Bruno Brotons, Núria Vivancos, Laia Beà, Manuel Sánchez-Martín, Stefania Landolfi, Javier Hernandez-Losa, Santiago Ramon y Cajal, Rocío Nieto, María Vicario, Ricard Farre, Simo Schwartz, Jr., Sven C.D. van Ijzendoorn, Kazuto Kobayashi, Águeda Martinez-Barriocanal, Diego Arango
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109400- (2024)
Summary: Rho GTPases are molecular switches regulating multiple cellular processes. To investigate the role of RhoA in normal intestinal physiology, we used a conditional mouse model overexpressing a dominant negative RhoA mutant (RhoAT19N) in the in
Externí odkaz:
https://doaj.org/article/9d852163178f465ea052ec089ed5a27d
Autor:
María José Ruiz-Pastor, Xavier Sánchez-Sáez, Oksana Kutsyr, Henar Albertos-Arranz, Carla Sánchez-Castillo, Isabel Ortuño-Lizarán, Natalia Martínez-Gil, Lorena Vidal-Gil, Lucía Méndez, Manuel Sánchez-Martín, Victoria Maneu, Pedro Lax, Nicolás Cuenca
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-17 (2023)
Abstract Central areolar choroidal dystrophy is an inherited disorder characterized by progressive choriocapillaris atrophy and retinal degeneration and is usually associated with mutations in the PRPH2 gene. We aimed to generate and characterize a m
Externí odkaz:
https://doaj.org/article/e0e59e4df12f4f508050012bf7b865b6
Autor:
Fernando Sánchez-Sáez, Raquel Sainz-Urruela, Natalia Felipe-Medina, Yazmine B. Condezo, Manuel Sánchez-Martín, Elena Llano, Alberto M. Pendás
Publikováno v:
Cells, Vol 11, Iss 22, p 3706 (2022)
Meiosis is a highly conserved specialized cell division process that generates haploid gametes. Many of its events are associated with dynamically regulated chromosomal structures and chromatin remodeling, which are mainly modulated by histone modifi
Externí odkaz:
https://doaj.org/article/7bf345bdb42a4b218aed5460b1545e54
Autor:
Jésica Pérez-García, Abel Martel-Martel, Paula García-Vallés, Luis A. Corchete, Juan L. García, Nerea Gestoso-Uzal, Rosario Vidal-Tocino, Óscar Blanco, Lucía Méndez, Manuel Sánchez-Martín, Manuel Fuentes, Ana B. Herrero, Andreana N. Holowatyj, José Perea, Rogelio González-Sarmiento
Publikováno v:
Cancers, Vol 14, Iss 16, p 4029 (2022)
The incidence of early-onset colorectal cancer (EOCRC; age younger than 50 years) has been progressively increasing over the last decades globally, with causes unexplained. A distinct molecular feature of EOCRC is that compared with cases of late-ons
Externí odkaz:
https://doaj.org/article/cbca0ba9f48246e19f75afc5a120f832
Autor:
Elena Vuelta, José L. Ordoñez, David J. Sanz, Sandra Ballesteros, Jesús M. Hernández-Rivas, Lucía Méndez-Sánchez, Manuel Sánchez-Martín, Ignacio García-Tuñón
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6386 (2022)
Chronic myeloid leukaemia (CML) is a haematological neoplasm driven by the BCR/ABL fusion oncogene. The monogenic aspect of the disease and the feasibility of ex vivo therapies in haematological disorders make CML an excellent candidate for gene ther
Externí odkaz:
https://doaj.org/article/15d472f820954c5fab3388e1d2d5c3e9
Autor:
Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, Ignacio García-Tuñón, Manuel Sánchez-Martín, Ángel Hernández-Hernández
Publikováno v:
Haematologica, Vol 106, Iss 1 (2020)
The regulation of protein function by reversible oxidation is increasingly recognized as a key mechanism for the control of cellular signaling, modulating crucial biological processes such as cell differentiation. In this scenario, NADPH oxidases mus
Externí odkaz:
https://doaj.org/article/ece7c130a93e41759a244432feea5802
Autor:
Rodrigo Prieto-Bermejo, Marta Romo-González, Alejandro Pérez-Fernández, María Carmen García-Macías, Carmen Sánchez-Bernal, Ignacio García-Tuñón, Jesús Sánchez-Yagüe, Manuel Sánchez-Martín, Ángel Hernández-Hernández
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8701 (2021)
Haematopoiesis is a paradigm of cell differentiation because of the wide variety and overwhelming number of mature blood cells produced daily. Under stress conditions, the organism must adapt to a boosted demand for blood cells. Chronic granulomatous
Externí odkaz:
https://doaj.org/article/631e180724c94dde8625e7053ced956d
Autor:
Laura Gómez-H, Natalia Felipe-Medina, Manuel Sánchez-Martín, Owen R. Davies, Isabel Ramos, Ignacio García-Tuñón, Dirk G. de Rooij, Ihsan Dereli, Attila Tóth, José Luis Barbero, Ricardo Benavente, Elena Llano, Alberto M. Pendas
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element
Externí odkaz:
https://doaj.org/article/5a816d0aaec44215a0dd259f498219bc
Autor:
Laura Gómez-H, Natalia Felipe-Medina, Yazmine B Condezo, Rodrigo Garcia-Valiente, Isabel Ramos, José Angel Suja, José Luis Barbero, Ignasi Roig, Manuel Sánchez-Martín, Dirk G de Rooij, Elena Llano, Alberto M Pendas
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008316 (2019)
The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. In mammals, the pr
Externí odkaz:
https://doaj.org/article/84914a7598074ee385fc28b2784651a2