Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Manuel S, Rodriguez"'
Autor:
Corentin Bouvier, Rachel Lawrence, Francesca Cavallo, Wendy Xolalpa, Allan Jordan, Roland Hjerpe, Manuel S. Rodriguez
Publikováno v:
Cells, Vol 13, Iss 7, p 578 (2024)
Proteolysis-targeting chimeras (PROTACs) describe compounds that bind to and induce degradation of a target by simultaneously binding to a ubiquitin ligase. More generally referred to as bifunctional degraders, PROTACs have led the way in the field o
Externí odkaz:
https://doaj.org/article/4bd15c3cb64b401fa3a65fab7f0f52dc
Autor:
Romane Leboutet, Céline Largeau, Leonie Müller, Magali Prigent, Grégoire Quinet, Manuel S Rodriguez, Marie-Hélène Cuif, Thorsten Hoppe, Emmanuel Culetto, Christophe Lefebvre, Renaud Legouis
Publikováno v:
eLife, Vol 12 (2023)
The ubiquitin-like proteins Atg8/LC3/GABARAP are required for multiple steps of autophagy, such as initiation, cargo recognition and engulfment, vesicle closure and degradation. Most of LC3/GABARAP functions are considered dependent on their post-tra
Externí odkaz:
https://doaj.org/article/bc2befe847e845c490254ece309a0f61
Autor:
Grégoire Quinet, Pierre Génin, Oznur Ozturk, Naima Belgareh-Touzé, Lilas Courtot, Renaud Legouis, Robert Weil, Mickael M. Cohen, Manuel S. Rodriguez
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Autophagy is an essential cellular pathway that ensures degradation of a wide range of substrates including damaged organelles or large protein aggregates. Understanding how this proteolytic pathway is regulated would increase our comprehens
Externí odkaz:
https://doaj.org/article/08b4ab36610f46e8925d67d37f5ac0b8
Autor:
Ana Sofia Carvalho, Henrique Baeta, Bruno Costa Silva, Maria Carolina Strano Moraes, Cristian Bodo, Hans Christian Beck, Manuel S. Rodriguez, Mayank Saraswat, Akhilesh Pandey, Rune Matthiesen
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 25, Iss 3, Pp 398-436 (2020)
Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs p
Externí odkaz:
https://doaj.org/article/fd69bf5388ef4187ab9df6b5e3388fec
Autor:
Immacolata Giordano, Lucia Pirone, Veronica Muratore, Eukene Landaluze, Coralia Pérez, Valerie Lang, Elisa Garde-Lapido, Monika Gonzalez-Lopez, Orhi Barroso-Gomila, Alfred C. O. Vertegaal, Ana M. Aransay, Jose Antonio Rodriguez, Manuel S. Rodriguez, James D. Sutherland, Rosa Barrio
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes. Here we analyze the relationship between two key transcription factors:
Externí odkaz:
https://doaj.org/article/9f902c27741442058737cfdbacf033b4
Autor:
Chantal M. Maghames, Sofia Lobato-Gil, Aurelien Perrin, Helene Trauchessec, Manuel S. Rodriguez, Serge Urbach, Philippe Marin, Dimitris P. Xirodimas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Protein NEDDylation increases upon proteotoxic stress but the function of this response remains to be elucidated. Here, the authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregat
Externí odkaz:
https://doaj.org/article/85faf55d5a3042e781053e60dc0a6572
Akademický článek
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Autor:
Romane Leboutet, Céline Largeau, Magali Prigent, Grégoire Quinet, Manuel S Rodriguez, Leonie Müller, Thorsten Hoppe, Marie-Hélène Cuif, Emmanuel Culetto, Christophe Lefebvre, Renaud Legouis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::132f584440312ba48d62feaed9fd6526
https://doi.org/10.15252/rc.2023159510
https://doi.org/10.15252/rc.2023159510
Publikováno v:
Molecules, Vol 25, Iss 10, p 2352 (2020)
Protein degradation is tightly regulated inside cells because of its utmost importance for protein homeostasis (proteostasis). The two major intracellular proteolytic pathways are the ubiquitin-proteasome and the autophagy-lysosome systems which ensu
Externí odkaz:
https://doaj.org/article/55b2972f11164e33ae0d8b04acdc0381
Autor:
Arantza Azpilikueta, Elixabet Bolaños, Valerie Lang, Sara Labiano, Maria A. Aznar, Iñaki Etxeberria, Alvaro Teijeira, Maria E. Rodriguez-Ruiz, Jose L. Perez-Gracia, Maria Jure-Kunkel, Juan M. Zapata, Manuel S. Rodriguez, Ignacio Melero
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
TRAF2 dependent K63-polyubiquitinations have been recently shown to connect CD137 (4–1BB) stimulation to NF-κB activation. In a search of deubiquitinase enzymes (DUBs) that could regulate such a signaling route, A20 and CYLD were found to coimmuno
Externí odkaz:
https://doaj.org/article/022068d6125a462a82274c3b8d1b8e58