Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Manuel Rosa Garrido"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Cardiac sex differences represent a pertinent focus in pursuit of the long-awaited goal of personalized medicine. Despite evident disparities in the onset and progression of cardiac pathology between sexes, historical oversight has led to the neglect
Externí odkaz:
https://doaj.org/article/240f2013e0d044af8789e6559e7b86d3
Autor:
Yang Cao, Laurent Vergnes, Yu-Chen Wang, Calvin Pan, Karthickeyan Chella Krishnan, Timothy M. Moore, Manuel Rosa-Garrido, Todd H. Kimball, Zhiqiang Zhou, Sarada Charugundla, Christoph D. Rau, Marcus M. Seldin, Jessica Wang, Yibin Wang, Thomas M. Vondriska, Karen Reue, Aldons J. Lusis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this paper, the authors show that sex differences in mitochondrial DNA levels and function in the heart contribute to sex biases in functions relevant to heart failure, identifying Acsl6 as a mitochondrial sex-biased regulator of diastolic functio
Externí odkaz:
https://doaj.org/article/89de6b77175046a88778990393d83932
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Background: We had shown that cardiomyocytes (CMs) were more efficiently differentiated from human induced pluripotent stem cells (hiPSCs) when the hiPSCs were reprogrammed from cardiac fibroblasts rather than dermal fibroblasts or blood mononuclear
Externí odkaz:
https://doaj.org/article/598613ae2358421caa772939d51d9ed9
Autor:
Noemí Cabré, Fedra Luciano-Mateo, Douglas J. Chapski, Gerard Baiges-Gaya, Salvador Fernández-Arroyo, Anna Hernández-Aguilera, Helena Castañé, Elisabet Rodríguez-Tomàs, Marta París, Fàtima Sabench, Daniel Del Castillo, Josep M. del Bas, Mercedes Tomé, Clément Bodineau, Alejandro Sola-García, José López-Miranda, Alejandro Martín-Montalvo, Raúl V. Durán, Thomas M. Vondriska, Manuel Rosa-Garrido, Jordi Camps, Javier A. Menéndez, Jorge Joven
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7830 (2022)
The surgically induced remission of liver disease represents a model to investigate the signalling processes that trigger the development of nonalcoholic steatohepatitis with the aim of identifying novel therapeutic targets. We recruited patients wit
Externí odkaz:
https://doaj.org/article/98b8b7e9308e419daf0a83b1afd3442c
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2019)
Packaging of the genome in the nucleus is a non-random process that is thought to directly contribute to cell type-specific transcriptomes, although this hypothesis remains untested. Epigenome architecture, as assayed by chromatin conformation captur
Externí odkaz:
https://doaj.org/article/5ccc51d259fd464a8f622895287fe280
Autor:
Shuaishuai Hu, Douglas J. Chapski, Natalie Gehred, Todd H. Kimball, Tatiana Gromova, Angelina Flores, Amy C. Rowat, Junjie Chen, René R. Sevag Packard, Emily Olszewski, Jennifer Davis, Christoph D. Rau, Timothy A. McKinsey, Manuel Rosa Garrido, Thomas M. Vondriska
SummaryTuning of genome structure and function is accomplished by chromatin binding proteins, which determine the transcriptome and phenotype of the cell. We sought to investigate how communication between extracellular stress and chromatin structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1363c83902002223822dc37e46b5d9f8
https://doi.org/10.1101/2022.11.29.518399
https://doi.org/10.1101/2022.11.29.518399
Autor:
Adrian Arrieta, Anna Reese, David Wong, Douglas J Chapski, Manuel Rosa-Garrido, Ashley Zhu, Thomas M Vondriska
Publikováno v:
Circulation Research. 131
Background: During neonatal cardiac development, myocytes integrate cues such as changes in blood pressure and circulating hormones to execute a temporal genetic response that drives physiological cardiac hypertrophy. Chromatin remodeling precedes th
Autor:
Caitlin Lahue, Brian Gural, Abdalla Alkhawaja, Douglas Chapski, Manuel Rosa-Garrido, Eleanor Wong, Wilson Tan, Shuxun Ren, Roger Foo, Thomas M Vondriska, Yibin Wang, Christoph Rau
Publikováno v:
Circulation Research. 131
Background: Heart Failure (HF) is driven by the interactions of multiple genetic, epigenetic, and environmental factors both within and between the cell types of the heart. Our lab uses the Hybrid Mouse Diversity Panel (HMDP), a large cohort of inbre
Autor:
Todd Kimball, Douglas Chapski, Ashley Agubata, Vincent Ren, Yibin Wang, Manuel Rosa-Garrido, Thomas Vondriska
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:103-104
Publikováno v:
Journal of Molecular and Cellular Cardiology. 151:89-105
Recent technological advancements in the field of chromatin biology have rewritten the textbook on nuclear organization. We now appreciate that the folding of chromatin in the three-dimensional space (i.e. its 3D "architecture") is non-random, hierar