Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Manuel Rodríguez-Puyol"'
Autor:
Marco Hatem-Vaquero, Sergio de Frutos, Alicia Luengo, Alba González Abajo, Mercedes Griera, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Laura Calleros
Publikováno v:
Nefrología, Vol 38, Iss 6, Pp 639-646 (2018)
Resumen: Antecedentes: Los pacientes con enfermedad renal crónica presentan una acumulación de toxinas urémicas, las cuales han sido identificadas como agentes patogénicos asociados con la mortalidad cardiovascular, muy elevada en este grupo de e
Externí odkaz:
https://doaj.org/article/29862fc8f4bd49f6976d0d04d01b01ae
Autor:
Marco Hatem-Vaquero, Sergio de Frutos, Alicia Luengo, Alba González Abajo, Mercedes Griera, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Laura Calleros
Publikováno v:
Nefrología (English Edition), Vol 38, Iss 6, Pp 639-646 (2018)
Background: Patients with chronic kidney disease present with an accumulation of uremic toxins, which have been identified as pathogenic agents associated with cardiovascular mortality, which is very high is this patient group. A phenomenon common to
Externí odkaz:
https://doaj.org/article/3846886d4c704e468fc52dd21887f004
Autor:
Patricia Martínez-Miguel, Viviana Raoch, Carlos Zaragoza, Jose Manuel Valdivielso, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Susana López-Ongil
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 364-375 (2009)
The aim of our study was to analyze the relationships between atherosclerosis and endothelin-converting enzyme-1 (ECE-1). Four-week-old C57BL/6J [wild-type (WT)] and apolipoprotein E-deficient (apoE) mice were fed with a standard or Western-type fat
Externí odkaz:
https://doaj.org/article/1fde79c581ae411da276a18984c6413c
Autor:
Manuel Rodríguez-Puyol, Javier García-Marín, Sergio de Frutos, Ramón Alajarín, Juan J. Vaquero, Mercedes Griera-Merino, Diego Rodríguez-Puyol, Alejandra Matamoros-Recio
Publikováno v:
e_Buah Biblioteca Digital Universidad de Alcalá
instname
ACS Medicinal Chemistry Letters
instname
ACS Medicinal Chemistry Letters
Integrin-linked kinase (ILK) has emerged as a controversial pseudokinase protein that plays a crucial role in the signaling process initiated by integrin-mediated signaling. However, ILK also exhibits a scaffolding protein function inside cells, cont
Autor:
Ramón Alajarín, Javier García-Marín, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Juan J. Vaquero, Mercedes Griera
Publikováno v:
e_Buah Biblioteca Digital Universidad de Alcalá
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Chemmedchem
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Chemmedchem
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
13 p.-9 fig.-3 tab.
Protein tyrosine phosphatase 1B (PTP1B) is a very promising target for the treatment of metabolic disorders such as type II diabetes mellitus. Although it was validated as a promising target for this disease more than 30 year
Protein tyrosine phosphatase 1B (PTP1B) is a very promising target for the treatment of metabolic disorders such as type II diabetes mellitus. Although it was validated as a promising target for this disease more than 30 year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17986e7e90ffe68407050f5f25e07404
https://hdl.handle.net/10017/53965
https://hdl.handle.net/10017/53965
Autor:
Mercedes Griera, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Alicia Luengo, Alba González Abajo, Sergio de Frutos, Marco Hatem-Vaquero, Laura Calleros
Publikováno v:
Nefrología, Vol 38, Iss 6, Pp 639-646 (2018)
Resumen: Antecedentes: Los pacientes con enfermedad renal crónica presentan una acumulación de toxinas urémicas, las cuales han sido identificadas como agentes patogénicos asociados con la mortalidad cardiovascular, muy elevada en este grupo de e
Autor:
Manuel Rodríguez-Puyol, Ramón Alajarín, Javier García-Marín, Beatriz de Pascual-Teresa, Juan J. Vaquero, Francisco Mendicuti, Patricia Sánchez-Alonso, Bruno Di Geronimo, Mercedes Griera, Diego Rodríguez-Puyol
Publikováno v:
ChemMedChem. 15(19)
PTP1B dephosphorylates insulin receptor and substrates to modulate glucose metabolism. This enzyme is a validated therapeutic target for type 2 diabetes, but no current drug candidates have completed clinical trials. Pyrrolo[1,2-a]quinoxalines substi
Autor:
Manuel Rodríguez-Puyol, Patricia Sosa, Maria Piedad Ruiz, María Angeles Caballero, Ana Asenjo-Bueno, Patricia Plaza, Elena Alcalde-Estévez, Gemma Olmos, Susana López-Ongil
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Hyperphosphatemia has been associated with aging and chronic kidney disease (CKD). Sarcopenia, which is a related condition of these pathologies, is defined by loss of force and muscular mass. During aging, chronic systemic inflam
Autor:
Laura Calleros, Diego García-Ayuso, Mercedes Griera-Merino, Manuel Rodríguez-Puyol, Sergio De Frutos García, Diego Rodríguez-Puyol, Sofía Campillo de Blas, Lourdes Bohorquez Magro, Marta Barrionuevo-González, Elena Gutiérrez-Calabrés
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Insulin resistance (IR)-related metabolic disorders, such as diabetes type 2 and obesity, are linked to renal and cardiovascular risk. Unfortunately, they lack a better prognosis before their full establishment. An important mecha
Autor:
Sofía Campillo de Blas, Mercedes Griera-Merino, Lourdes Bohorquez Magro, Manuel Rodríguez-Puyol, Laura Calleros, David Vaillo, Diego Rodríguez-Puyol, Diego García-Ayuso, Elena Gutiérrez-Calabrés, Sergio De Frutos García
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Important mechanism associated to the development of Insulin resistance (IR) are dysregulation of lipid adjustment and excessive deposition of extracellular matrix (ECM) in the visceral white adipose tissue (WAT). The transgenic d