Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Manuel Rodríguez Paredes"'
Autor:
Sabrina Schütz, Llorenç Solé-Boldo, Carlota Lucena-Porcel, Jochen Hoffmann, Alexander Brobeil, Anke S. Lonsdorf, Manuel Rodríguez-Paredes, Frank Lyko
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cutaneous squamous cell carcinoma (cSCC) is a serious public health problem due to its high incidence and metastatic potential. It may progress from actinic keratosis (AK), a precancerous lesion, or the in situ carcinoma, Bowen’s disease (
Externí odkaz:
https://doaj.org/article/7dfd2b2a17394f908dbe8cf7eb3a6200
Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses
Autor:
Llorenç Solé‐Boldo, Günter Raddatz, Julian Gutekunst, Oliver Gilliam, Felix Bormann, Michelle S Liberio, Daniel Hasche, Wiebke Antonopoulos, Jan‐Philipp Mallm, Anke S Lonsdorf, Manuel Rodríguez‐Paredes, Frank Lyko
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp 1-22 (2022)
Abstract Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations, posing a significant medical and economic burden to health systems. KC originate in the epidermis and mainly comprise basal cell carcinoma (BCC) and
Externí odkaz:
https://doaj.org/article/f1877efb7d4b4f92a9c149e53c79c250
Autor:
Jonas Koch, Manuel Neuberger, Martina Schmidt-Dengler, Jinyun Xu, Vitor Coutinho Carneiro, Jörg Ellinger, Maximilian C. Kriegmair, Philipp Nuhn, Philipp Erben, Maurice Stephan Michel, Mark Helm, Manuel Rodríguez-Paredes, Malin Nientiedt, Frank Lyko
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107300- (2023)
Summary: METTL3 is the major writer of N6-Methyladenosine (m6A) and has been associated with controversial roles in cancer. This is best illustrated in urothelial carcinoma of the bladder (UCB), where METTL3 was described to have both oncogenic and t
Externí odkaz:
https://doaj.org/article/9811c78962a84ac8864006c4041344a1
Autor:
Florian Köhler, Felix Bormann, Günter Raddatz, Julian Gutekunst, Samuel Corless, Tanja Musch, Anke S. Lonsdorf, Sylvia Erhardt, Frank Lyko, Manuel Rodríguez-Paredes
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals exp
Externí odkaz:
https://doaj.org/article/00088c8a4a8149b6ae3e7d7c5020a4fa
Autor:
Felix Bormann, Manuel Rodríguez-Paredes, Felix Lasitschka, Dominic Edelmann, Tanja Musch, Axel Benner, Yehudit Bergman, Sebastian M. Dieter, Claudia R. Ball, Hanno Glimm, Heinz G. Linhart, Frank Lyko
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3407-3418 (2018)
Summary: Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, prov
Externí odkaz:
https://doaj.org/article/e86c318f3a9a4f9bb5b8774c69ab0e1e
Autor:
Manuel Rodríguez-Paredes, Felix Bormann, Günter Raddatz, Julian Gutekunst, Carlota Lucena-Porcel, Florian Köhler, Elisabeth Wurzer, Katrin Schmidt, Stefan Gallinat, Horst Wenck, Joachim Röwert-Huber, Evgeniya Denisova, Lars Feuerbach, Jeongbin Park, Benedikt Brors, Esther Herpel, Ingo Nindl, Thomas G. Hofmann, Marc Winnefeld, Frank Lyko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from dis
Externí odkaz:
https://doaj.org/article/26b413b8fcbb4405904d85c489f5f2a2
Autor:
Elena Gómez-Marín, Melanija Posavec-Marjanović, Laura Zarzuela, Laura Basurto-Cayuela, José A Guerrero-Martínez, Gonzalo Arribas, Rosario Yerbes, María Ceballos-Chávez, Manuel Rodríguez-Paredes, Mercedes Tomé, Raúl V Durán, Marcus Buschbeck, José C Reyes
Publikováno v:
Nucleic Acids Research. 50:9838-9857
High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. The protein HMG20A is predicted by the AlphaFold2 software to contain three distinct structural elements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9ecd6c96d7adaa0fa9313e24ee7d2b
https://doi.org/10.1093/nar/gkac766
https://doi.org/10.1093/nar/gkac766
Autor:
Laura Wiehle, Günter Raddatz, Stefan Pusch, Julian Gutekunst, Andreas von Deimling, Manuel Rodríguez-Paredes, Frank Lyko
Publikováno v:
Cell Stress, Vol 1, Iss 1, Pp 55-67 (2017)
Isocitrate dehydrogenases 1 and 2 (IDH1/2) are recurrently mutated in acute myeloid leukemia (AML), but their mechanistic role in leukemogenesis is poorly understood. The inhibition of TET enzymes by D-2-hydroxyglutarate (D-2-HG), which is produced b
Externí odkaz:
https://doaj.org/article/6a4c908b649d42ec9d47b5fa4fa3fc7b
Autor:
Andreas Trumpp, Martin R. Sprick, Wilko Weichert, Oliver Strobel, Janel L. Kopp, Ilse Rooman, H. Efsun Arda, Dieter Weichenhan, Katja Steiger, Benedikt Brors, Christoph Plass, Thilo Hackert, Nicole Pfarr, Matthias Schlesner, Roland Eils, Hsi-Yu Yen, Elisa Donato, Manuel Rodríguez-Paredes, Matthias M. Gaida, Soheila Zarei, Elyne Backx, Alex Y.L. Lee, Karnjit Sarai, Alexander Muckenhuber, Steffi O. Kossi, Vera Thiel, Manuel Reitberger, Jacob Insua-Rodríguez, Mattia Falcone, Vanessa Vogel, Corinna Klein, Silke Weisenburger, Mariam Safavi, Magdalena Büscher, Nathalia A. Giese, Charles D. Imbusch, Zuguang Gu, Elisa Espinet
Supplementary Figures S1 to S15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6bcfdd799ab0ad68bc5c33c677dcd0
https://doi.org/10.1158/2159-8290.22536175.v1
https://doi.org/10.1158/2159-8290.22536175.v1
