Effects of regorafenib on the mononuclear/phagocyte system and how these contribute to the inhibition of colorectal tumors in mice

Autor: Sylvia Grünewald, Maria Stecklum, Manuel Rizzo, Jonathan Rathjens, Lukas Fiebig, Dieter Zopf

Publikováno v: European Journal of Medical Research, Vol 28, Iss 1, Pp 1-13 (2023)

Abstract Background Regorafenib was previously shown to reduce tumor-associated macrophages and potently inhibit colony-stimulating factor 1 receptor (CSF1R), also known as CD115, in biochemical assays. The CSF1R signaling pathway is essential in the

Externí odkaz: https://doaj.org/article/93fe5b77d1f04ab5b5e6f2ba7319b804

Detection and estimation of additive outliers in seasonal time series

Autor: Domenico Cucina, Francesco Battaglia, Manuel Rizzo

The detection of outliers in a time series is an important issue because their presence may have serious negative effects on the analysis in many different ways. Moreover the presence of a complex seasonal pattern in the series could affect the prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b3481f8f7a4a1a0ee52133cd06838e
https://hdl.handle.net/11590/372791

Parsimonious periodic autoregressive models for time series with evolving trend and seasonality

Autor: Francesco Battaglia, Domenico Cucina, Manuel Rizzo

This paper proposes an extension of Periodic AutoRegressive (PAR) modelling for time series with evolving features. The large scale of modern datasets, in fact, implies that the time span may subtend several evolving patterns of the underlying series

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dd867af35a1adcd939d2c795f1a425
https://hdl.handle.net/11590/354894

Multiple changepoint detection for periodic autoregressive models with an application to river flow analysis

Autor: Eugen Ursu, Manuel Rizzo, Domenico Cucina

Publikováno v: Stochastic Environmental Research and Risk Assessment
Stochastic Environmental Research and Risk Assessment, Springer Verlag (Germany), In press, 33 (4-6), pp.1137-1157. ⟨10.1007/s00477-019-01692-0⟩

In river flow analysis and forecasting there are some key elements to consider in order to obtain reliable results. For example, seasonality is often accounted for in statistical models because climatic oscillations occurring every year have an obvio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce09f22a45b0dab42b5d739a4a4e69c
https://hal.archives-ouvertes.fr/hal-02878506

Identification of multiregime periodic autoregressive models by genetic algorithms

Autor: Domenico Cucina, Manuel Rizzo, Eugen Ursu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::594f88340af0aad7d353f384633bb5d7
http://hdl.handle.net/11386/4717114