Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Manuel Rhiel"'
Autor:
Vigneshwaran Venkatesan, Abisha Crystal Christopher, Manuel Rhiel, Manoj Kumar K. Azhagiri, Prathibha Babu, Kaivalya Walavalkar, Bharath Saravanan, Geoffroy Andrieux, Sumathi Rangaraj, Saranya Srinivasan, Karthik V. Karuppusamy, Annlin Jacob, Abhirup Bagchi, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Rekha Pai, Srujan Kumar Marepally, Kumarasamypet Murugesan Mohankumar, Shaji R. Velayudhan, Melanie Boerries, Dimple Notani, Toni Cathomen, Alok Srivastava, Saravanabhavan Thangavel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 671-688 (2023)
Reactivation of fetal hemoglobin (HbF) is a commonly adapted strategy to ameliorate β-hemoglobinopathies. However, the continued production of defective adult hemoglobin (HbA) limits HbF tetramer production affecting the therapeutic benefits. Here,
Externí odkaz:
https://doaj.org/article/444686798a7c40d7a355be2ff089b162
Autor:
Ruba Hammad, Jamal Alzubi, Manuel Rhiel, Kay O. Chmielewski, Laura Mosti, Julia Rositzka, Marcel Heugel, Jan Lawrenz, Valentina Pennucci, Birgitta Gläser, Judith Fischer, Axel Schambach, Thomas Moritz, Nico Lachmann, Tatjana I. Cornu, Claudio Mussolino, Richard Schäfer, Toni Cathomen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 985 (2024)
The CRISPR-Cas12a platform has attracted interest in the genome editing community because the prototypical Acidaminococcus Cas12a generates a staggered DNA double-strand break upon binding to an AT-rich protospacer-adjacent motif (PAM, 5′-TTTV). Th
Externí odkaz:
https://doaj.org/article/119eb899f651407ca1f5944ad9f5c6cc
Autor:
Ala Dibas, Manuel Rhiel, Vidisha Bhavesh Patel, Geoffroy Andrieux, Melanie Boerries, Tatjana I. Cornu, Jamal Alzubi, Toni Cathomen
Publikováno v:
Cells, Vol 12, Iss 21, p 2581 (2023)
While chimeric antigen receptor (CAR) T cell therapy has shown promising outcomes among patients with hematologic malignancies, it has also been associated with undesirable side-effects such as cytokine release syndrome (CRS). CRS is triggered by CAR
Externí odkaz:
https://doaj.org/article/bf43cad4c6ab4739b2fc2db99a085e44
Autor:
Manuel Rhiel, Kerstin Geiger, Geoffroy Andrieux, Julia Rositzka, Melanie Boerries, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Transcription activator-like effector nucleases (TALENs) are programmable nucleases that have entered the clinical stage. Each subunit of the dimer consists of a DNA-binding domain composed of an array of TALE repeats fused to the catalytically activ
Externí odkaz:
https://doaj.org/article/cdd565ffee514bbdabc0f8daa0adbfe8
Autor:
Jamal Alzubi, Dominik Lock, Manuel Rhiel, Sabrina Schmitz, Stefan Wild, Claudio Mussolino, Markus Hildenbeutel, Caroline Brandes, Julia Rositzka, Simon Lennartz, Simone A. Haas, Kay O. Chmielewski, Thomas Schaser, Andrew Kaiser, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 379-388 (2021)
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contaminatio
Externí odkaz:
https://doaj.org/article/e8aa757ae0ec4109904f3108d8338f68
Autor:
Saskia König, Manfred Fliegauf, Manuel Rhiel, Bodo Grimbacher, Tatjana I. Cornu, Toni Cathomen, Claudio Mussolino
Publikováno v:
Genes, Vol 13, Iss 10, p 1912 (2022)
Dominant negative mutations in the STAT3 gene account for autosomal dominant hyper-IgE syndrome (AD-HIES). Patients typically present high IgE serum levels, recurrent infections, and soft tissue abnormalities. While current therapies focus on allevia
Externí odkaz:
https://doaj.org/article/5266a3cfee8f4a0d9b8d629f543e5e1b
Autor:
Tomasz M. Witkos, Wing Lee Chan, Merja Joensuu, Manuel Rhiel, Ed Pallister, Jane Thomas-Oates, A. Paul Mould, Alex A. Mironov, Christophe Biot, Yann Guerardel, Willy Morelle, Daniel Ungar, Felix T. Wieland, Eija Jokitalo, May Tassabehji, Uwe Kornak, Martin Lowe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
COPI is recruited to the membrane by binding to Arf GTPases. Here the authors find that GORAB, a trans-Golgi protein, promotes COPI recruitment by forming membrane domains that also contain the COPI-interacting protein Scyl1, which is required for ef
Externí odkaz:
https://doaj.org/article/dc9f0e13809c4552a229477915667865
Autor:
Jamal Alzubi, Dominik Lock, Manuel Rhiel, Sabrina Schmitz, Stefan Wild, Claudio Mussolino, Markus Hildenbeutel, Caroline Brandes, Julia Rositzka, Simon Lennartz, Simone A. Haas, Kay O. Chmielewski, Thomas Schaser, Andrew Kaiser, Toni Cathomen, Tatjana I. Cornu
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 379-388 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 379-388 (2021)
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated with production failure and product contaminatio
Autor:
Marianna Romito, Alexandre Juillerat, Yik Lim Kok, Markus HIldenbeutel, Manuel Rhiel, Geoffroy Andrieux, Johannes Geiger, Carsten Rudolph, Claudio Mussolino, Aymeric Duclert, Karin Metzner, Philippe Duchateau, Toni Cathomen, Tatjana Cornu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8be911dec1765bbbd32add1d649420e
https://doi.org/10.22541/au.158990011.12602649
https://doi.org/10.22541/au.158990011.12602649
Autor:
Philippe Duchateau, Claudio Mussolino, Johannes Geiger, Aymeric Duclert, Markus Hildenbeutel, Alexandre Juillerat, Geoffroy Andrieux, Tatjana I. Cornu, Carsten Rudolph, Marianna Romito, Yik Lim Kok, Manuel Rhiel, Toni Cathomen, Karin J. Metzner
Publikováno v:
Biotechnology journal. 16(1)
Therapies to treat patients infected with human immunodeficiency virus (HIV) aim at preventing viral replication but fail to eliminate the virus. Although transplantation of allogeneic CCR5Δ32 homozygous stem cell grafts provided a cure for a few pa