Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Manuel Portero‐Otín"'
Autor:
Laia Fontdevila, Mònica Povedano, Raúl Domínguez, Jordi Boada, José CE Serrano, Reinald Pamplona, Victòria Ayala, Manuel Portero-Otín
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract This study aimed to assess differences in the enteral microbiome of relatively recent-onset amyotrophic lateral sclerosis (ALS) patients (
Externí odkaz:
https://doaj.org/article/51a806644fe64eb99cfee408084435b1
Autor:
Miriam Ceron-Codorniu, Pascual Torres, Anna Fernàndez-Bernal, Santiago Rico-Rios, José CE. Serrano, Maria P. Miralles, Maria Beltran, Ana Garcera, Rosa M. Soler, Reinald Pamplona, Manuel Portero-Otín
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103301- (2024)
The dysfunction of TAR DNA-binding protein 43 (TDP-43) is implicated in various neurodegenerative diseases, though the specific contributions of its toxic gain-of-function versus loss-of-function effects remain unclear. This study investigates the im
Externí odkaz:
https://doaj.org/article/216d6a56aee44db79da4fca5f601d662
Autor:
Joaquim Sol, Marta Ortega-Bravo, Manuel Portero-Otín, Gerard Piñol-Ripoll, Vicent Ribas-Ripoll, Eva Artigues-Barberà, Miquel Butí, Reinald Pamplona, Mariona Jové
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Slower paces of aging are related to lower risk of developing diseases and premature death. Therefore, the greatest challenge of modern societies is to ensure that the increase in lifespan is accompanied by an increase in health s
Externí odkaz:
https://doaj.org/article/579474dfcd3a4f3b9cb39d56a32e4d23
Autor:
Rebeca Berdún, Èlia Obis, Natàlia Mota-Martorell, Anna Bassols, Daniel Valent, José C. E. Serrano, Meritxell Martín-Garí, María Rodríguez-Palmero, José Antonio Moreno-Muñoz, Joan Tibau, Raquel Quintanilla, Reinald Pamplona, Manuel Portero-Otín, Mariona Jové
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 161 (2024)
Obesity is a risk factor for highly prevalent age-related neurodegenerative diseases, the pathogenesis of whichinvolves mitochondrial dysfunction and protein oxidative damage. Lipoxidation, driven by high levels of peroxidizable unsaturated fatty aci
Externí odkaz:
https://doaj.org/article/b3d3efe6744443ce93845815c53b86f3
Autor:
José C. E. Serrano, Eva Castro-Boqué, Alicia García-Carrasco, María Inés Morán-Valero, Daniel González-Hedström, Marcelino Bermúdez-López, José Manuel Valdivielso, Alberto E. Espinel, Manuel Portero-Otín
Publikováno v:
Nutrients, Vol 15, Iss 17, p 3691 (2023)
The use of garlic (Allium sativum) for treating arterial hypertension has been recognized as effective for several decades. However, tolerance to treatment is low, and several technological modifications have been developed to improve its tolerabilit
Externí odkaz:
https://doaj.org/article/adf90d84b69640f892df99bcf4650ce2
Autor:
Pascual Torres, Carlos Anerillas, Omar Ramírez-Núñez, Anna Fernàndez, Mario Encinas, Mònica Povedano, Pol Andrés-Benito, Isidre Ferrer, Victòria Ayala, Reinald Pamplona, Manuel Portero-Otín
Publikováno v:
Disease Models & Mechanisms (2022)
To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous
Externí odkaz:
https://doaj.org/article/75192e82160841c9854369915c3bfd6b
Autor:
Mariona Jové, Natàlia Mota-Martorell, Èlia Obis, Joaquim Sol, Meritxell Martín-Garí, Isidre Ferrer, Manuel Portero-Otín, Reinald Pamplona
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 177 (2023)
It is assumed that the human brain is especially susceptible to oxidative stress, based on specific traits such as a higher rate of mitochondrial free radical production, a high content in peroxidizable fatty acids, and a low antioxidant defense. How
Externí odkaz:
https://doaj.org/article/166d70b397c54cc6ace3a8b9df8c773e
Autor:
Francisco Purroy, Enric Sánchez, Albert Lecube, Gloria Arqué, Mikel Vicente-Pascual, Gerard Mauri-Capdevila, Núria Torreguitart, Marta Hernández, Ferrán Barbé, Elvira Fernández, Reinald Pamplona, Cristina Farràs, Dídac Mauricio, Marcelino Bermúdez-López, the ILERVAS project, José Manuel Valdivielso, Serafí Cambray, Eva Castro, Montserrat Martínez-Alonso, Manuel Portero-otín, Mariona Jové, Ferran Rius, Jessica González, Silvia Barril, Gerard Torres, Pere Godoy, Eva Miquel, Marta Ortega, Esmeralda Castelblanco, Josep Franch-Nadal
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background: Little is known about the prevalence of cerebral microangiopathy (CM), which is related to cognitive impairment, in an asymptomatic population. Pulsatility index (PI) is an easily measurable parameter of cerebral vascular resistance in tr
Externí odkaz:
https://doaj.org/article/0ba309dcdfd4489fa8c0dee7016e106b
Autor:
Ángela del Castillo-Izquierdo, José María Moreno-Navarrete, Jessica Latorre, María Arnoriaga-Rodríguez, Marta Ballanti, Giovanni Monteleone, Omero Alessandro Paoluzi, Geltrude Mingrone, Josep Puig, Rafael Ramos, Josep Garre-Olmo, Mariona Jové, Reinald Pamplona, Manuel Portero-Otín, Joaquim Sol, Philippe Lefebvre, Bart Staels, Massimo Federici, José Manuel Fernández-Real, Jordi Mayneris-Perxachs
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2177 (2022)
Dipeptidyl peptidase 9 (DPP9) is a member of the dipeptidyl peptidase IV family. Inhibition of DPP9 has recently been shown to activate the nucleotide-binding domain leucine-rich repeat 1 (NLRP1) inflammasome. NLRP1 is known to bind nucleic acids wit
Externí odkaz:
https://doaj.org/article/ca7a7aa43585444bb2cd8f18b4ed149b
Autor:
Ana Belen Granado-Serrano, Meritxell Martín-Garí, Virginia Sánchez, Marissa Riart Solans, Antonia Lafarga Giribets, Rebeca Berdún, Ester Vilaprinyó, Manuel Portero-Otín, José C. E. Serrano
Publikováno v:
Nutrients, Vol 14, Iss 3, p 525 (2022)
This study aimed to determine how the microbiota profile might be predisposed to a better response in blood lipid profiles due to dietary fibre supplementation. A three-arm intervention study that included three different fibre types (mainly insolubl
Externí odkaz:
https://doaj.org/article/00616777778644258fdadd1ba6976bab