Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Manuel Portero"'
Autor:
Laia Fontdevila, Mònica Povedano, Raúl Domínguez, Jordi Boada, José CE Serrano, Reinald Pamplona, Victòria Ayala, Manuel Portero-Otín
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract This study aimed to assess differences in the enteral microbiome of relatively recent-onset amyotrophic lateral sclerosis (ALS) patients (
Externí odkaz:
https://doaj.org/article/51a806644fe64eb99cfee408084435b1
Autor:
Miriam Ceron-Codorniu, Pascual Torres, Anna Fernàndez-Bernal, Santiago Rico-Rios, José CE. Serrano, Maria P. Miralles, Maria Beltran, Ana Garcera, Rosa M. Soler, Reinald Pamplona, Manuel Portero-Otín
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103301- (2024)
The dysfunction of TAR DNA-binding protein 43 (TDP-43) is implicated in various neurodegenerative diseases, though the specific contributions of its toxic gain-of-function versus loss-of-function effects remain unclear. This study investigates the im
Externí odkaz:
https://doaj.org/article/216d6a56aee44db79da4fca5f601d662
Autor:
Joaquim Sol, Marta Ortega-Bravo, Manuel Portero-Otín, Gerard Piñol-Ripoll, Vicent Ribas-Ripoll, Eva Artigues-Barberà, Miquel Butí, Reinald Pamplona, Mariona Jové
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Slower paces of aging are related to lower risk of developing diseases and premature death. Therefore, the greatest challenge of modern societies is to ensure that the increase in lifespan is accompanied by an increase in health s
Externí odkaz:
https://doaj.org/article/579474dfcd3a4f3b9cb39d56a32e4d23
Autor:
Irene García Toledo, Juan Miguel Godoy Corchuelo, Zeinab Ali, Jesús Jimenez-Rodriguez, Irene Jimenez-Coca, Anna Fernández-Bernal, Mariona Jové, Èlia Obis, Jorge Matias-Guiu, Thommas Cunningham, Manuel Portero-Otin, Reinald Pamplona, Estela Area-Gomez, Silvia Corrochano
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S409- (2023)
Externí odkaz:
https://doaj.org/article/f70be57aa2d54e7bbf8ffee89f5dfa42
Autor:
Rebeca Berdún, Èlia Obis, Natàlia Mota-Martorell, Anna Bassols, Daniel Valent, José C. E. Serrano, Meritxell Martín-Garí, María Rodríguez-Palmero, José Antonio Moreno-Muñoz, Joan Tibau, Raquel Quintanilla, Reinald Pamplona, Manuel Portero-Otín, Mariona Jové
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 161 (2024)
Obesity is a risk factor for highly prevalent age-related neurodegenerative diseases, the pathogenesis of whichinvolves mitochondrial dysfunction and protein oxidative damage. Lipoxidation, driven by high levels of peroxidizable unsaturated fatty aci
Externí odkaz:
https://doaj.org/article/b3d3efe6744443ce93845815c53b86f3
Publikováno v:
Cells, Vol 12, Iss 13, p 1684 (2023)
Insulin resistance (IR) is commonly observed during aging and is at the root of many of the chronic nontransmissible diseases experienced as people grow older. Many factors may play a role in causing IR, but diet is undoubtedly an important one. Whet
Externí odkaz:
https://doaj.org/article/3317616a883647d19156ba057ceac0a5
Autor:
Pascual Torres, Carlos Anerillas, Omar Ramírez-Núñez, Anna Fernàndez, Mario Encinas, Mònica Povedano, Pol Andrés-Benito, Isidre Ferrer, Victòria Ayala, Reinald Pamplona, Manuel Portero-Otín
Publikováno v:
Disease Models & Mechanisms (2022)
To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous
Externí odkaz:
https://doaj.org/article/75192e82160841c9854369915c3bfd6b
Autor:
María Arnoriaga-Rodríguez, Jordi Mayneris-Perxachs, Aurelijus Burokas, Vicente Pérez-Brocal, Andrés Moya, Manuel Portero-Otin, Wifredo Ricart, Rafael Maldonado, José-Manuel Fernández-Real
Publikováno v:
Microbiome, Vol 8, Iss 1, Pp 1-10 (2020)
Abstract Background The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations of gut bacter
Externí odkaz:
https://doaj.org/article/9743bb5719b149bea9b8999d1331a269
Autor:
Mariona Jové, Natàlia Mota-Martorell, Èlia Obis, Joaquim Sol, Meritxell Martín-Garí, Isidre Ferrer, Manuel Portero-Otin, Reinald Pamplona
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 293 (2023)
One of the richest tissues in lipid content and diversity of the human body is the brain. The human brain is constitutively highly vulnerable to oxidative stress. This oxidative stress is a determinant in brain aging, as well as in the onset and prog
Externí odkaz:
https://doaj.org/article/a383516e892f45008dfc4fed86ba6b68
Autor:
Mariona Jové, Natàlia Mota-Martorell, Èlia Obis, Joaquim Sol, Meritxell Martín-Garí, Isidre Ferrer, Manuel Portero-Otín, Reinald Pamplona
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 177 (2023)
It is assumed that the human brain is especially susceptible to oxidative stress, based on specific traits such as a higher rate of mitochondrial free radical production, a high content in peroxidizable fatty acids, and a low antioxidant defense. How
Externí odkaz:
https://doaj.org/article/166d70b397c54cc6ace3a8b9df8c773e