Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness

Autor: Sandra Muñoz-Galván, Blanca Felipe-Abrio, Eva M. Verdugo-Sivianes, Marco Perez, Manuel P. Jiménez-García, Elisa Suarez-Martinez, Purificacion Estevez-Garcia, Amancio Carnero

Publikováno v: Molecular Cancer, Vol 19, Iss 1, Pp 1-16 (2020)

Abstract Background Ovarian cancer is one of the most common and malignant cancers, partly due to its late diagnosis and high recurrence. Chemotherapy resistance has been linked to poor prognosis and is believed to be linked to the cancer stem cell (

Externí odkaz: https://doaj.org/article/ad7f3ea6697f4f288783b7c2b9e5acc6

Supplementary Data from NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP

Autor: Amancio Carnero, Sandra Muñoz-Galvan, Manuel P. Jiménez-García, Daniel Otero-Albiol, Antonio Lucena-Cacace

Figure S1: Overall survival probability of the patients according to NAMPT levels segregated by colon cancer stage. Figure S2. Tumorigenic properties induces by NAMPT Figure S3. Effect of a second shRNA against NAMPT in the tumorigenic capability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9440764a79e1a0bdcbae254e6dfc39
https://doi.org/10.1158/1078-0432.22465461

Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis

Autor: Daniel Otero-Albiol, Antonio Lucena-Cacace, Manuel P. Jiménez-García, Amancio Carnero

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)

[Background] Sarcomas are a very heterogeneous group of tumors with intrinsic developmental programs derived from the cell of origin. This implies a functional hierarchy inside tumors governed by sarcoma stem cells. Therefore, genetic and/or epigenet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c259fa769ae7a79e1f5a9062bf99665
http://europepmc.org/articles/PMC8348834

NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP

Autor: Daniel Otero-Albiol, Sandra Muñoz-Galván, Amancio Carnero, Antonio Lucena-Cacace, Manuel P. Jiménez-García

Publikováno v: Clinical Cancer Research. 24:1202-1215

Purpose: Colorectal cancer is the second most common cancer in women and the third most common in men worldwide. However, despite current progress, many patients with advanced and metastatic tumors still die from the malignancy. Refractory disease of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f8e834fa07c8eebf2c20bd4c0c8372
https://doi.org/10.1158/1078-0432.ccr-17-2575

New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools

Autor: Manuel P. Jiménez-García, Daniel Otero-Albiol, Elisa Suarez-Martinez, Amancio Carnero, Adoración G. Quiroga, Blanca Felipe-Abrio, Asunción Espinosa-Sánchez, Lola E. Navas, Eva M. Verdugo-Sivianes, Julia Domínguez-Piñol, Purificacion Estevez-Garcia, Sandra Muñoz-Galván, Juan Marín, Miguel García-Carrasco, José M. García-Heredia

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Digital.CSIC. Repositorio Institucional del CSIC

[Background] Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response probability to subsequent lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29f9ddcd8136f42d5b5e8b1f491efa2
https://hdl.handle.net/10668/3169