Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Manuel O. Diaz"'
Autor:
Manuel O. Diaz, Nancy J. Zeleznik-Le, Michael J. Thirman, Roger Luo, Wei Wei, Mark Koonce, Donna A. Santillan, Jing Chen
Supplementary Figures 1-2 from Loss of MLL PHD Finger 3 Is Necessary for MLL-ENL–Induced Hematopoietic Stem Cell Immortalization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8b2a71490085bc2444dc43a7647b3c
https://doi.org/10.1158/0008-5472.22371117
https://doi.org/10.1158/0008-5472.22371117
Autor:
Manuel O. Diaz, Nancy J. Zeleznik-Le, Michael J. Thirman, Roger Luo, Wei Wei, Mark Koonce, Donna A. Santillan, Jing Chen
Reciprocal chromosomal translocations at the MLL gene locus result in expression of novel fusion proteins, such as MLL-ENL, associated with leukemia. The three PHD finger cassette, one of the highly conserved domains in MLL, is absent in all fusion p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28a6f5cf8775a00775f1e610be8aedbc
https://doi.org/10.1158/0008-5472.c.6496671
https://doi.org/10.1158/0008-5472.c.6496671
Autor:
Markus Blatter, Charlotte Meylan, Antoine Cléry, Roberto Giambruno, Yaroslav Nikolaev, Michel Heidecker, Jessica Arvindbhai Solanki, Manuel O. Diaz, Davide Gabellini, Frédéric H.-T. Allain
Publikováno v:
Science Advances, 9 (16)
Mixed-lineage leukemia 1 (MLL1) is a transcription activator of the HOX family, which binds to specific epigenetic marks on histone H3 through its third plant homeodomain (PHD3) domain. Through an unknown mechanism, MLL1 activity is repressed by cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03131604c531e493919b5477b8954e8
Autor:
Sergio Moreno, Ruben Olivares, José A. Salvadó, Jose M. Cabello, Manuel O. Diaz, Alfredo Velasco
Publikováno v:
Journal of Urology. 197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37994af82e45e1c9d6024ec934c244f5
https://doi.org/10.1016/j.juro.2017.02.1547
https://doi.org/10.1016/j.juro.2017.02.1547
Publikováno v:
Blood. 134:2969-2969
Background: Myeloproliferative neoplasms (MPNs), commonly polycythemia vera (PV), primary myelofibrosis (PMF) and essential thrombocythemia (ET), are a group of malignant hematologic disorders characterized by proliferation and accumulation of termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eb916073ac18c9a73a39a29699c1837
https://doi.org/10.1182/blood-2019-124805
https://doi.org/10.1182/blood-2019-124805
Autor:
Shyh Jen Shih, Manuel O. Diaz, Dawei Lin, Andrew T M Vaughan, Joseph Fass, Vincent Buffalo, Sheetal Singh
Publikováno v:
British Journal of Haematology. 159:50-57
Summary MLL rearrangements were analysed in the blood of a patient receiving chemotherapy for diffuse large B-cell lymphoma using inverse polymerase chain reaction targeting exon 12, parallel sequencing and a custom algorithm design. Of thirteen MLL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ac3e030c186929236fc6a2d7cae05c
https://doi.org/10.1111/j.1365-2141.2012.09248.x
https://doi.org/10.1111/j.1365-2141.2012.09248.x
Publikováno v:
Actas Urológicas Españolas (English Edition). 35:119-122
Introduction Primary hyperaldosteronism is one of the few potentially curable causes of secondary arterial hypertension. One of the most important variants is the adenoma of the adrenal cortex that produces aldosterona (Conn's Syndrome). The treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca53542115344d1463f483411b342bd
https://doi.org/10.1016/s2173-5786(11)70031-2
https://doi.org/10.1016/s2173-5786(11)70031-2
Autor:
Gayathree Raman, Rebecca H. Schwantes, Sangho Park, John H. Bushweller, Manuel O. Diaz, Ute Osmers
Publikováno v:
Biochemistry
The mixed lineage leukemia (MLL) gene plays a critical role in epigenetic regulation of gene expression and is a frequent target of chromosomal translocations leading to leukemia. MLL plant homeodomain 3 (PHD3) is lost in all MLL translocation produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05417b8a2175b436e9a5f7f4f964e28d
https://doi.org/10.1021/bi1009387
https://doi.org/10.1021/bi1009387
Autor:
Yinshi Guo, Wei Wei, Stephan W. Morris, Gladell P. Paner, Ameet R. Kini, Peter Breslin, Minghui Tang, Manuel O. Diaz, Jiwang Zhang, Patrick J. Stiff, Serhan Alkan, Shubin Zhang, Chao Niu
Publikováno v:
Blood. 114:2097-2106
It has been found that c-Myc protein plays a critical role in controlling self-renewal versus differentiation in hematopoietic stem cells. We report that c-Myc also controls the fate of megakaryocyte-erythrocyte progenitors through regulating the dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fe6be9197bb6dba46d7621dc0318b6
https://doi.org/10.1182/blood-2009-01-197947
https://doi.org/10.1182/blood-2009-01-197947
Autor:
Mark A. Koonce, Roger T. Luo, Donna A. Santillan, Nancy J. Zeleznik-Le, Wei Wei, Michael J. Thirman, Manuel O. Diaz, Jing Chen
Publikováno v:
Cancer Research. 68:6199-6207
Reciprocal chromosomal translocations at the MLL gene locus result in expression of novel fusion proteins, such as MLL-ENL, associated with leukemia. The three PHD finger cassette, one of the highly conserved domains in MLL, is absent in all fusion p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c788f6b774beeb62eb37fe4ef2b33a7
https://doi.org/10.1158/0008-5472.can-07-6514
https://doi.org/10.1158/0008-5472.can-07-6514