Zobrazeno 1 - 10
of 421
pro vyhledávání: '"Manuel Nogueras"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9744 (2024)
The inhibition of the hLDHA (human lactate dehydrogenase A) enzyme has been demonstrated to be of great importance in the treatment of cancer and other diseases, such as primary hyperoxalurias. In that regard, we have designed, using virtual docking
Externí odkaz:
https://doaj.org/article/e0dadf432ea148ee87ba64b9c3ba741d
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 4579-4595 (2019)
A high-throughput method to obtain several pyrimido[4,5-e][1,4]diazepines is described by a two-step acylation/cyclization sequence from key intermediates 6-amino-5-(amino)methylpyrimidines, which were prepared from the precursor 6-aminopyrimidin-5-c
Externí odkaz:
https://doaj.org/article/f357075dca744b38a51c46dbfd616092
Autor:
Lina Fernanda Castaño, Jairo Quiroga, Rodrigo Abonia, Daniel Insuasty, Oscar M. Vidal, Rosalia Seña, Vivian Rubio, Gloria Puerto, Manuel Nogueras, Justo Cobo, Juan Guzman, Alberto Insuasty, Braulio Insuasty
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12589 (2022)
A new series of sulfonamides, 8a-b, 10, 12, and 14a-b, were synthesized by N-sulfonation reaction with sulfonyl chlorides 6a-b. Five new series of chalcone-sulfonamide hybrids (16-20)a-f were prepared via Claisen–Schmidt condensation of the newly o
Externí odkaz:
https://doaj.org/article/e82eae18a7db4659bf3ce3168d2cec16
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 792 (2022)
A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were stud
Externí odkaz:
https://doaj.org/article/53ffc590be2245bc951f32c4e08a141b
Publikováno v:
Molecules, Vol 19, Iss 11, Pp 18656-18675 (2014)
A new series of NH-pyrazoline derivatives 6 was synthesized by cyclocondensation reaction of novel [(7-chloroquinolin-4-yl)oxy]chalcones 5 with hydrazine hydrate. The treatment of pyrazolines 6 with acetic anhydride or formic acid yielded the N-acety
Externí odkaz:
https://doaj.org/article/8409cf05ed6c47b987eb671d29cf8a41
Autor:
José M. de la Torre, Manuel Nogueras, Eduardo J. Borkowski, Fernando D. Suvire, Ricardo D. Enriz, Justo Cobo
Publikováno v:
ARKIVOC, Vol 2014, Iss 5, Pp 42-63 (2014)
Externí odkaz:
https://doaj.org/article/703d7516a8dc4355b4ed917ffbed03af
Autor:
Jairo Quiroga, Jaime Gálvez, Rodrigo Abonia, Braulio Insuasty, Alejandro Ortíz, Justo Cobo, Manuel Nogueras
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4284-4300 (2014)
Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields. The reactions proceeded by
Externí odkaz:
https://doaj.org/article/39ff6b3b4f1740b9968a60f72dd5585a
Autor:
Susana A. Zacchino, Justo Cobo, María Victoria Rodríguez, Manuel Nogueras, Rodrigo Abonia, Jairo Quiroga, Carlos Echeverry, Marcela Raimondi, Juan Ramírez, Alberto Insuasty, Braulio Insuasty
Publikováno v:
Molecules, Vol 18, Iss 5, Pp 5482-5497 (2013)
New hetaryl- and alkylidenerhodanine derivatives 3a–d, 3e, and 4a–d were prepared from heterocyclic aldehydes 1a–d or acetaldehyde 1e. The treatment of several rhodanine derivatives 3a–d and 3e with piperidine or morpholine in THF under reflu
Externí odkaz:
https://doaj.org/article/c9610e177bc8496b87b41411191122ad
Publikováno v:
Applied Sciences, Vol 3, Iss 2, Pp 457-468 (2013)
A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines
Externí odkaz:
https://doaj.org/article/d0f83f3d702543e1939ba9b9235be68c
Autor:
Justo Cobo, José M. de la Torre, Manuel Nogueras, Jairo Quiroga, Luis Gabriel López, Dency José Pacheco, Jorge Trilleras
Publikováno v:
Molecules, Vol 15, Iss 10, Pp 7227-7234 (2010)
A series of pyrimido[4,5-b]quinolines (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N4-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-di
Externí odkaz:
https://doaj.org/article/fd9a9f8d892043e7b59af8bf4196d499