The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5

Autor: Onur K. Polat, Elena Isaeva, Yashwanth R. Sudhini, Brenna Knott, Ke Zhu, Manuel Noben, Varsha Suresh Kumar, Nicole Endlich, Steve Mangos, Tejasree Vallapu Reddy, Beata Samelko, Changli Wei, Mehmet M. Altintas, Stuart E. Dryer, Sanja Sever, Alexander Staruschenko, Jochen Reiser

Publikováno v: Kidney International. 103:1056-1062

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b169b5a4adcceab2673ea3d0b2a3a2d
https://doi.org/10.1016/j.kint.2023.01.016

Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology

Autor: Severine Vermeire, Wiebe Vanhove, Kaline Arnauts, Marc Ferrante, Gert Van Assche, Catherine M. Verfaillie, Manuel Noben, Anabela S. Ramalho

Publikováno v: United European Gastroenterology Journal

Determining the exact pathogenesis of chronic gastrointestinal diseases remains difficult due to the complex in vivo environment. In this review we give an overview of the available epithelial cell culture systems developed to investigate pathophysio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e10fe93c59381755f15342ab9fecdd2
https://europepmc.org/articles/PMC5721984/

Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease

Autor: Kris Nys, Sebastiaan De Schepper, Gert Van Assche, Isabelle Cleynen, Manuel Noben, Ingrid Arijs, Marc Ferrante, Wiebe Vanhove, Severine Vermeire

Publikováno v: Journal of Crohns and Colitis
Journal of Crohn's and Colitis

Background Endoplasmic reticulum [ER] stress was shown to be pivotal in the pathogenesis of inflammatory bowel disease. Despite progress in inflammatory bowel disease [IBD] drug development, not more than one-third of patients achieve steroid-free re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ce4e1bd96080b0a2a8f28ad389e47c
https://pubmed.ncbi.nlm.nih.gov/29029005

Helicobacter pylori gamma-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance

Autor: Joachim Maxeiner, Mathias Oertli, Anne Müller, Raphaela P. Semper, Manuel Noben, Markus Gerhard, Daniela B. Engler, Christian Taube, Sebastian Reuter

Publikováno v: Proceedings of the National Academy of Sciences, 110(8), 3047-3052
Proc Natl Acad Sci U S A.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection with the gastric bacterial pathogen Helicobacter pylori is typically contracted in early childhood and often persists for decades. The immunomodulatory properties of H. pylori that allow it to colonize humans persistently are believed to al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7938d68376b4e96f758d28b03b6cd377
https://hdl.handle.net/1887/102258

DOP052 Active smoking, and pre-operative anti-flagellin Fla2 and pANCA antibodies may predict postoperative Crohn's disease recurrence: results from a prospective mono-centric trial

Autor: A. de Buck van Overstraeten, G. De Hertogh, Sharat Singh, G. Van Assche, A. Wolthuis, Fred Princen, A. D'Hoore, Severine Vermeire, Manuel Noben, Steven Lockton, Marc Ferrante

Publikováno v: Journal of Crohn's and Colitis. 8:S39-S40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c17de5375fb8986296a3e2faefce97b
https://doi.org/10.1016/s1873-9946(14)60077-5