Feasability of Introducing a Thioether Ring in Vasopressin by nisBTC Co-expression in Lactococcus lactis

Autor: Qian Li, Manuel Montalban-Lopez, Oscar P. Kuipers

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Introducing one or more intramolecular thioether bridges in a peptide provides a promising approach to create more stable molecules with improved pharmacodynamic properties and especially to protect peptides against proteolytic degradation. Lanthipep

Externí odkaz: https://doaj.org/article/ee95af2ecebe414697f2decabab0ebe8

Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers

Autor: Manuel Montalban, Xiqun Chen, Jamal I. Alkabsh, Sarah Huntwork-Rodriguez, Michael A. Schwarzschild, Giuseppe Astarita, Junhua Wang, Eric A. Macklin, Rachit Bakshi, Alberto Ascherio, Romeo Maciuca, Sonnet S. Davis, Grace F. Crotty

Publikováno v: Neurology. 95:e3428-e3437

ObjectiveTo identify markers of resistance to developing Parkinson disease (PD) among LRRK2 mutation carriers (LRRK2+), we carried out metabolomic profiling in individuals with PD and unaffected controls (UC), with and without the LRRK2 mutation.Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65db1f390a80107fd757e0fd977bd274
https://doi.org/10.1212/wnl.0000000000010863

Procalcitonin as a biomarker for acute kidney injury in patients with sepsis and septic shock

Autor: Guillermo Garcia-Garcia, Jose Manuel Montalban-Castellanos, Jonathan S Chávez-Iñiguez, Rodolfo Alejandro Moreno-Alvarado, Luis Arnoldo Muñoz-Nevárez, Evelyn Fabiola Morraz-Mejía, Marisol López-Ceja

Publikováno v: Revista Colombiana de Nefrología, Vol 6, Iss 2, Pp 130-137 (2019)
Revista Colombiana de Nefrología, Volume: 6, Issue: 2, Pages: 130-137, Published: DEC 2019

Resumen Introducción: hasta el 60 % de los pacientes con sepsis desarrollan daño renal agudo. La procalcitonina indica la presencia de sepsis y puede predecir un daño renal agudo. Objetivos: determinar los valores de procalcitonina como biomarcado

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047131babdcadb5c8aa139e23cd18e04
https://revistanefrologia.org/index.php/rcn/article/view/351

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10

Autor: Michael T. Maloney, Manuel Montalban, Vitaliy V. Bondar, Nathan J. Moerke, Shan V. Andrews, Xiang Wang, Elvira Negrou, Laralynne Przybyla, Hilda Solanoy, Anastasia G. Henry, Romeo Maciuca, Sarah Huntwork-Rodriguez, Hoang Nguyen, Annie Arguello, Ceyda Llapashtica

Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, including the common variant G2019S, result in increased LRRK2 kinase act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87a9d65082cebaaff4815f08ad800704
https://doi.org/10.1101/2021.02.23.432545

Association of caffeine and related analytes with resistance to Parkinson disease among

Autor: Grace F, Crotty, Romeo, Maciuca, Eric A, Macklin, Junhua, Wang, Manuel, Montalban, Sonnet S, Davis, Jamal I, Alkabsh, Rachit, Bakshi, Xiqun, Chen, Alberto, Ascherio, Giuseppe, Astarita, Sarah, Huntwork-Rodriguez, Michael A, Schwarzschild

Publikováno v: Neurology
article-version (Version of Record) 3

Objective To identify markers of resistance to developing Parkinson disease (PD) among LRRK2 mutation carriers (LRRK2+), we carried out metabolomic profiling in individuals with PD and unaffected controls (UC), with and without the LRRK2 mutation. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa6024e003e6007403c93830cb3878db
https://pubmed.ncbi.nlm.nih.gov/32999056