Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Manuel Modolell"'
Autor:
Janny A Villa-Pulgarín, Consuelo Gajate, Javier Botet, Alberto Jimenez, Nicole Justies, Rubén E Varela-M, Álvaro Cuesta-Marbán, Ingrid Müller, Manuel Modolell, José L Revuelta, Faustino Mollinedo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005805 (2017)
Leishmaniasis is the world's second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from satisfactory. Alkylphospholipid analogs (APLs) are a family of anticancer drugs that show antileis
Externí odkaz:
https://doaj.org/article/b4bc8ef28cd54018b172542ea561c88d
Autor:
Fitsumbrhan Tajebe, Mulusew Getahun, Emebet Adem, Asrat Hailu, Mulualem Lemma, Helina Fikre, John Raynes, Aschalew Tamiru, Zemenay Mulugeta, Ermias Diro, Frederic Toulza, Ziv Shkedy, Tadesse Ayele, Manuel Modolell, Markus Munder, Ingrid Müller, Yegnasew Takele, Pascale Kropf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 7, p e0005727 (2017)
Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver a
Externí odkaz:
https://doaj.org/article/baeaf3ed0b6d4290a34c34a2b38f2ac5
Autor:
Endalew Yizengaw, Mulusew Getahun, Fitsumbrhan Tajebe, Edward Cruz Cervera, Getnet Mesfin, Emebet Adem, Asrat Hailu, Gert Van der Auwera, Vanessa Yardley, Mulualem Lemma, Ziv Skhedy, Ermias Diro, Arega Yeshanew, Roma Melkamu, Bewketu Mengesha, Manuel Modolell, Markus Munder, Ingrid Muller, Yegnasew Teferi, Pascale Kropf
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication. Neutrophils are highly versatile cells, which play a
Externí odkaz:
https://doaj.org/article/0dc483362745420490529fe575be1a0a
Autor:
Emebet Adem, Fitsumbirhan Tajebe, Mulusew Getahun, Amare Kiflie, Ermias Diro, Asrat Hailu, Ziv Shkedy, Bewketu Mengesha, Tadele Mulaw, Saba Atnafu, Tekalign Deressa, Biniam Mathewos, Ebba Abate, Manuel Modolell, Markus Munder, Ingrid Müller, Yegnasew Takele, Pascale Kropf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004468 (2016)
One of the key immunological characteristics of active visceral leishmaniasis (VL) is a profound immunosuppression and impaired production of Interferon-γ (IFN-γ). However, recent studies from Bihar in India showed using a whole blood assay, that w
Externí odkaz:
https://doaj.org/article/5313c0b6fcff41ee9f16ed5fff478c22
Autor:
Tamrat Abebe, Yegnasew Takele, Teklu Weldegebreal, Tom Cloke, Ellen Closs, Camille Corset, Asrat Hailu, Workagegnehu Hailu, Yifru Sisay, Karina Corware, Margaux Corset, Manuel Modolell, Markus Munder, Fabienne Tacchini-Cottier, Ingrid Müller, Pascale Kropf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2134 (2013)
The underlying mechanisms resulting in the profound immune suppression characteristic of human visceral leishmaniasis (VL) are not fully understood. Here, we tested the hypothesis that arginase, an enzyme associated with immunosuppression, is higher
Externí odkaz:
https://doaj.org/article/2fe3c333c0614eedb99cb50119d9a622
Autor:
Tom Cloke, Markus Munder, Philip Bergin, Shanthi Herath, Manuel Modolell, Graham Taylor, Ingrid Müller, Pascale Kropf
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72034 (2013)
We have recently identified a novel population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells of HIV seropositive patients. LDGs have a similar morphology to normal density granulocytes (NDGs), but are phenotypical
Externí odkaz:
https://doaj.org/article/c74905dffe104b7491452b073a52b792
Autor:
Yegnasew Takele, Tamrat Abebe, Teklu Weldegebreal, Asrat Hailu, Workagegnehu Hailu, Zewdu Hurissa, Jemal Ali, Ermiyas Diro, Yifru Sisay, Tom Cloke, Manuel Modolell, Markus Munder, Fabienne Tacchini-Cottier, Ingrid Müller, Pascale Kropf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 1 (2013)
Externí odkaz:
https://doaj.org/article/94e8ecbe65294b1cb560e9a6b2db2dba
Autor:
Yegnasew Takele, Tamrat Abebe, Teklu Weldegebreal, Asrat Hailu, Workagegnehu Hailu, Zewdu Hurissa, Jemal Ali, Ermiyas Diro, Yifru Sisay, Tom Cloke, Manuel Modolell, Markus Munder, Fabienne Tacchini-Cottier, Ingrid Müller, Pascale Kropf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 1, p e1977 (2013)
Visceral leishmaniasis is a parasitic disease associated with high mortality. The most important foci of visceral leishmaniasis in Ethiopia are in the Northwest and are predominantly associated with high rates of HIV co-infection. Co-infection of vis
Externí odkaz:
https://doaj.org/article/c517bfa47b964ef9aef2a757bb0024e5
Local increase of arginase activity in lesions of patients with cutaneous leishmaniasis in Ethiopia.
Autor:
Tamrat Abebe, Asrat Hailu, Mihretu Woldeyes, Woinshet Mekonen, Kassahun Bilcha, Thomas Cloke, Lionel Fry, Nafisa-Katrin Seich Al Basatena, Karina Corware, Manuel Modolell, Markus Munder, Fabienne Tacchini-Cottier, Ingrid Müller, Pascale Kropf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 6, p e1684 (2012)
Cutaneous leishmaniasis is a vector-borne disease that is in Ethiopia mainly caused by the parasite Leishmania aethiopica. This neglected tropical disease is common in rural areas and causes serious morbidity. Persistent nonhealing cutaneous leishman
Externí odkaz:
https://doaj.org/article/c6af55791b7c43f3b862a69e1a7f587e
Autor:
Rubén E Varela-M, Janny A Villa-Pulgarin, Edward Yepes, Ingrid Müller, Manuel Modolell, Diana L Muñoz, Sara M Robledo, Carlos E Muskus, Julio López-Abán, Antonio Muro, Iván D Vélez, Faustino Mollinedo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1612 (2012)
BACKGROUND: The leishmaniases are a complex of neglected tropical diseases caused by more than 20 Leishmania parasite species, for which available therapeutic arsenal is scarce and unsatisfactory. Pentavalent antimonials (SbV) are currently the first
Externí odkaz:
https://doaj.org/article/1a8c62ffbbea481489e277e0e09c0a99