Zobrazeno 1 - 10
of 418
pro vyhledávání: '"Manuel Mayr"'
Autor:
Manar Elkenani, Javier Barallobre-Barreiro, Moritz Schnelle, Belal A. Mohamed, Bo E. Beuthner, Christoph Friedemann Jacob, Niels B. Paul, Xiaoke Yin, Konstantinos Theofilatos, Andreas Fischer, Miriam Puls, Elisabeth M. Zeisberg, Ajay M. Shah, Manuel Mayr, Gerd Hasenfuß, Karl Toischer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
AimsPatients with severe aortic stenosis (AS), low transvalvular flow (LF) and low gradient (LG) with normal ejection fraction (EF)—are referred to as paradoxical LF-LG AS (PLF-LG). PLF-LG patients develop more advanced heart failure symptoms and h
Externí odkaz:
https://doaj.org/article/66c50dcf5e0d438197600afb3e70ea8d
Autor:
Guanhong Miao, Raimund Pechlaner, Oliver Fiehn, Kimberly M. Malloy, Ying Zhang, Jason G. Umans, Manuel Mayr, Johann Willeit, Stefan Kiechl, Jinying Zhao
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background Dyslipidemia is an independent risk factor for coronary heart disease (CHD). Standard lipid panel cannot capture the complexity of the blood lipidome (ie, all molecular lipids in the blood). To date, very few large‐scale epidemiological
Externí odkaz:
https://doaj.org/article/bb5f5b085ef44c80a5ea23240606d18b
Autor:
Mirjana Malnar Črnigoj, Urša Čerček, Xiaoke Yin, Manh Tin Ho, Barbka Repic Lampret, Manuela Neumann, Andreas Hermann, Guy Rouleau, Beat Suter, Manuel Mayr, Boris Rogelj
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one disease mechanism, sense and antisense transcripts of the repeat are pre
Externí odkaz:
https://doaj.org/article/b29cd3b5c510491ea05a97aba7af8fed
Autor:
Sara G. Romeo, Ilaria Secco, Edoardo Schneider, Christina M. Reumiller, Celio X. C. Santos, Anna Zoccarato, Vishal Musale, Aman Pooni, Xiaoke Yin, Konstantinos Theofilatos, Silvia Cellone Trevelin, Lingfang Zeng, Giovanni E. Mann, Varun Pathak, Kevin Harkin, Alan W. Stitt, Reinhold J. Medina, Andriana Margariti, Manuel Mayr, Ajay M. Shah, Mauro Giacca, Anna Zampetaki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The microvasculature plays a key role in tissue perfusion and exchange of gases and metabolites. In this study we use human blood vessel organoids (BVOs) as a model of the microvasculature. BVOs fully recapitulate key features of the human m
Externí odkaz:
https://doaj.org/article/353954422197417aa51e7b271e88c1e2
Autor:
Irina Zalivina, Temo Barwari, Xiaoke Yin, Sarah R. Langley, Javier Barallobre-Barreiro, Hiroko Wakimoto, Anna Zampetaki, Manuel Mayr, Metin Avkiran, Seda Eminaga
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100056- (2023)
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder, characterized by cardiomyocyte hypertrophy, cardiomyocyte disarray and fibrosis, which has a prevalence of ∼1: 200–500 and predisposes individuals to heart f
Externí odkaz:
https://doaj.org/article/b8223816a67346999e77b33054cf0c71
Autor:
Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. Sheffield, Clint L. Miller
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113380- (2023)
Summary: Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the arterial wall. CAD progression involves complex interactions and phenotypic plasticity among vascular and immune cell lineages. Single-cell RNA-seq (sc
Externí odkaz:
https://doaj.org/article/f36322cc9dc74a4986bc713522f0f6e4
Autor:
Elisa Duregotti, Christina M. Reumiller, Ursula Mayr, Maria Hasman, Lukas E. Schmidt, Sean A. Burnap, Konstantinos Theofilatos, Javier Barallobre-Barreiro, Arne Beran, Maria Grandoch, Alessandro Viviano, Marjan Jahangiri, Manuel Mayr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Adipose tissue is an important secretory organ, but less is known about the secretory activity of perivascular fat. Here the authors use proteomics analysis on secretomes from perivascular fat to identify neuronal growth regulator 1 as an adipocyte-d
Externí odkaz:
https://doaj.org/article/314f652efb89427593b06c3be4c7327b
Autor:
Clemens Gutmann, Manuel Mayr
Publikováno v:
Platelets, Vol 33, Iss 4, Pp 512-519 (2022)
Platelets are essential mediators of physiological hemostasis and pathological thrombosis. Currently available tests and markers of platelet activation did not prove successful in guiding treatment decisions for patients with cardiovascular disease,
Externí odkaz:
https://doaj.org/article/a32bffe2a00c449db4fb1dd6d25ae33a
Autor:
Ella Reed, Adam Fellows, Ruifang Lu, Marieke Rienks, Lukas Schmidt, Xiaoke Yin, Elisa Duregotti, Mona Brandt, Susanne Krasemann, Kristin Hartmann, Javier Barallobre-Barreiro, Owen Addison, Friederike Cuello, Arne Hansen, Manuel Mayr
Publikováno v:
Matrix Biology Plus, Vol 16, Iss , Pp 100122- (2022)
Aortic smooth muscle cells (SMCs) have an intrinsic role in regulating vessel homeostasis and pathological remodelling. In two-dimensional (2D) cell culture formats, however, SMCs are not embedded in their physiological extracellular matrix (ECM) env
Externí odkaz:
https://doaj.org/article/580ca8a960804e2e8115303fc00c8289
Autor:
Christian Schulte, Bhawana Singh, Konstantinos Theofilatos, Nils A. Sörensen, Jonas Lehmacher, Tau Hartikainen, Paul M. Haller, Dirk Westermann, Tanja Zeller, Stefan Blankenberg, Johannes T. Neumann, Manuel Mayr
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 1, Iss , Pp 100014- (2022)
Background: While cardiac-specific troponin (cTn) allows for rapid diagnosis of acute type 1 myocardial infarction (T1MI), its performance to differentiate acute myocardial injury (AI) or type 2 myocardial infarction (T2MI) is limited. The objective
Externí odkaz:
https://doaj.org/article/75d14cc3cae049b1911772c7ea12753e