Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Manuel Maler"'
Autor:
Jung-Hyun Lee, Christian Ostalecki, Timo Oberstein, Stefan Schierer, Elisabeth Zinser, Martin Eberhardt, Katja Blume, Bianca Plosnita, Lena Stich, Heiko Bruns, Roland Coras, Julio Vera-Gonzales, Manuel Maler, Andreas S. Baur
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103903- (2022)
Summary: Background: Plasma extracellular vesicles (pEV) can harbor a diverse array of factors including active proteases and the amyloid-precursor-protein (APP) cleavage product Aβ, involved in plaque formation in Alzheimer`s diseases (AD). A poten
Externí odkaz:
https://doaj.org/article/0ef1dff6be234781983852ab5596a110
Autor:
Carina Lehmer, Patrick Oeckl, Jochen H Weishaupt, Alexander E Volk, Janine Diehl‐Schmid, Matthias L Schroeter, Martin Lauer, Johannes Kornhuber, Johannes Levin, Klaus Fassbender, Bernhard Landwehrmeyer, German Consortium for Frontotemporal Lobar Degeneration, Martin H Schludi, Thomas Arzberger, Elisabeth Kremmer, Andrew Flatley, Regina Feederle, Petra Steinacker, Patrick Weydt, Albert C Ludolph, Dieter Edbauer, Markus Otto, Adrian Danek, Emily Feneberg, Sarah Anderl‐Straub, Christine von Arnim, Holger Jahn, Anja Schneider, Manuel Maler, Maryna Polyakova, Lina Riedl, Jens Wiltfang, Georg Ziegler
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 859-868 (2017)
Abstract The C9orf72 GGGGCC repeat expansion is a major cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). Non‐conventional repeat translation results in five dipeptide repeat proteins (DPRs), but their clinical utility
Externí odkaz:
https://doaj.org/article/48101d2464c042379d4ddcf8b0a5e918
Autor:
Sonja Schönecker, Christiane Neuhofer, Markus Otto, Albert Ludolph, Jan Kassubek, Bernhard Landwehrmeyer, Sarah Anderl-Straub, Elisa Semler, Janine Diehl-Schmid, Catharina Prix, Christian Vollmar, Juan Fortea, Deutsches FTLD-Konsortium, Hans-Jürgen Huppertz, Thomas Arzberger, Dieter Edbauer, Berend Feddersen, Marianne Dieterich, Matthias L. Schroeter, Alexander E. Volk, Klaus Fließbach, Anja Schneider, Johannes Kornhuber, Manuel Maler, Johannes Prudlo, Holger Jahn, Tobias Boeckh-Behrens, Adrian Danek, Thomas Klopstock, Johannes Levin, Carola Roßmeier, Franziska Albrecht, Katharina Schümberg, Sandrine Bisenius
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Background: The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so
Externí odkaz:
https://doaj.org/article/01f120886008472ab3b584a1d9e1e46a
Autor:
Anna-Lena Haas, Pauline Olm, Janine Utz, Eva-Maria Siegmann, Philipp Spitzer, Anna Florvaag, Manuel Alexander Schmidt, Arnd Doerfler, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler, Timo Jan Oberstein, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAlzheimer’s disease (AD) is indicated by a decrease in amyloid beta 42 (Aβ42) level or the Aβ42/Aβ40 ratio, and by increased levels of Tau with phosphorylated threonine at position 181 (pTau181) in cerebrospinal fluid (CSF) years bef
Externí odkaz:
https://doaj.org/article/a0515777f9ec40f49d049a47a82ea07a
Autor:
Eva-Maria Siegmann, Pauline Olm, Bernd Lenz, Christiane Mühle, Timo Jan Oberstein, Juan Manuel Maler, Johannes Kornhuber
Publikováno v:
Brain Sciences, Vol 13, Iss 9, p 1229 (2023)
The development of Alzheimer’s disease (AD) is influenced by sex hormones—estrogens and androgens in particular. However, the impact of prenatal sex hormone exposure is less clear; very few investigations have examined the relationship between th
Externí odkaz:
https://doaj.org/article/b603820ebfc34e1581061e5ead8425c6
Autor:
Janine Utz, Judith Berner, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Juan Manuel Maler, Philipp Spitzer
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
IntroductionIn Alzheimer’s disease, the severity of symptoms is linked to a loss of synaptic density and the spread of pathologically hyperphosphorylated tau. The established cerebrospinal fluid markers Aβ, tau and phospho-tau reflect the histopat
Externí odkaz:
https://doaj.org/article/9ae513643beb43a1a3d7623e36c195fd
Autor:
Timo Jan Oberstein, Janine Utz, Philipp Spitzer, Hans Wolfgang Klafki, Jens Wiltfang, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Astrocytes may not only be involved in the clearance of Amyloid beta peptides (Aβ) in Alzheimer's disease (AD), but appear to produce N-terminally truncated Aβ (Aβn−x) independently of BACE1, which generates the N-Terminus of Aβ starting with A
Externí odkaz:
https://doaj.org/article/a2e902a0eca44304b3e443ee4eb7ea2e
Autor:
Jochen A Sembill, Christoph Lusse, Mathias Linnerbauer, Maximilian I Sprügel, Anne Mrochen, Michael Knott, Tobias Engelhorn, Manuel Alexander Schmidt, Arnd Doerfler, Timo Jan Oberstein, Juan Manuel Maler, Johannes Kornhuber, Piotr Lewczuk, Veit Rothhammer, Stefan Schwab, Joji B Kuramatsu
Publikováno v:
Brain Communications.
Integrating CSF-biomarkers into diagnostic workup of patients with sporadic cerebral amyloid angiopathy may support early and correct identification. We aimed to identify and validate clinical- and CSF-biomarkers for in-vivo diagnosis of cerebral amy
Autor:
Timo Jan Oberstein, Lava Taha, Philipp Spitzer, Janina Hellstern, Martin Herrmann, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The neuropathological hallmarks of Alzheimer’s disease (AD), i.e., neuritic plaques and neurofibrillary tangles, consist of beta amyloid peptides (Aβ) and hyperphosphorylated Tau. These are accompanied by reactive microglia and astrocytes in the v
Externí odkaz:
https://doaj.org/article/7f4f140b5e3f40c6bdcc9e45982e687f
Autor:
Timo Jan Oberstein, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, Juan Manuel Maler
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 24-35 (2015)
The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by ac
Externí odkaz:
https://doaj.org/article/716113bc60174697895a62fcb024bb73