Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds

Autor: Alexandra G. Durán, Nuria Chinchilla, Ana M. Simonet, M. Teresa Gutiérrez, Jorge Bolívar, Manuel M. Valdivia, José M. G. Molinillo, Francisco A. Macías

Publikováno v: Toxins, Vol 15, Iss 5, p 348 (2023)

Naphthoquinones are a valuable source of secondary metabolites that are well known for their dye properties since ancient times. A wide range of biological activities have been described highlighting their cytotoxic activity, gaining the attention of

Externí odkaz: https://doaj.org/article/dac3774fee2746828d73a2da755c1289

Expression of the Highly Toxic Centromere Binding Protein CENP-B in E. coli Using the pET System in the Absence of the Inducer IPTG

Autor: J. Antonio Bocanegra, Luis A. Bejarano, Manuel M. Valdivia

Publikováno v: BioTechniques, Vol 22, Iss 5, Pp 798-802 (1997)

Externí odkaz: https://doaj.org/article/58e423e22618428d9e662e99f007360d

Bio-Guided Isolation of Acetogenins from Annona cherimola Deciduous Leaves: Production of Nanocarriers to Boost the Bioavailability Properties

Autor: José M. G. Molinillo, Francisco A. Macías, Maria Teresa Gutiérrez, Manuel M. Valdivia, Diego Megias, Alexandra G. Durán, Francisco J R Mejías

Publikováno v: Molecules
Volume 25
Issue 20
Molecules, Vol 25, Iss 4861, p 4861 (2020)
Molecules 2020, 25(20), 4861
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
Universidad de Cádiz

Annonaceous acetogenins (ACGs) are lipophilic polyketides isolated exclusively from Annonaceae. They are considered to be amongst the most potent antitumor compounds. Nevertheless, their applications are limited by their poor solubility. The isolatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a963b3db1314bc65c1dc482ca14b267b

γ-H2AX is present at mouse meiotic kinetochores

Autor: Andrea Guajardo, Alberto Viera, Julio S. Rufas, José A. Suja, Manuel M. Valdivia, María Teresa Parra

The histone variant H2AX phosphorylated on serine 139, named γ-H2AX, is a canonical DNA double-strand breaks marker. During mammalian meiotic prophase I, γ-H2AX participates in meiotic recombination, meiotic sex chromosome inactivation and meiotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be729ab938ad728b6bd1e1d4a573f91
https://doi.org/10.1101/2020.03.10.986273

Proteomics characterization of CENP-B epitope in Moroccan scleroderma patients with anti-centromere autoantibodies

Autor: Rajae El Aouad, Khaoula Hamdouch, Amina Barakat, Zeineb Zian, Manuel M. Valdivia, Naima Arji, Naima Ghailani Nourouti, Mouna Maamar, Mohcine Bennani Mechita

Publikováno v: Immunology letters. 221

Background Anti-centromere auto-antibodies (ACA) have been described as a marker in Systemic sclerosis (SSc) disease. CENP-B is the major centromere auto-antigen recognized by SSc patients with positive ACA. Our aim was to characterize the major epit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9724f59d3f24dabc384d135fcf9a23bd
https://pubmed.ncbi.nlm.nih.gov/32057908