Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Manuel Llinás"'
Autor:
Laura M. Hagenah, Satish K. Dhingra, Jennifer L. Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A. Schindler, Gabriel W. Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D. Roepe, Manuel Llinás, David A. Fidock
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTMalaria elimination efforts in Southeast Asia have been hindered by multidrug-resistant Plasmodium falciparum. High-grade resistance to piperaquine (PPQ, used in combination with dihydroartemisinin) is associated with PfCRT mutations that aro
Externí odkaz:
https://doaj.org/article/ccd09ec4400a4cee8b8849d9566f3a45
Autor:
Laura E. de Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M. J. Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito
Externí odkaz:
https://doaj.org/article/5a569da9aa694e86aa5e04aa0c21ba75
Autor:
John Okombo, Sachel Mok, Tarrick Qahash, Tomas Yeo, Jade Bath, Lindsey M Orchard, Edward Owens, Imhoi Koo, Istvan Albert, Manuel Llinás, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010926 (2022)
The emergence of Plasmodium falciparum parasite resistance to dihydroartemisinin + piperaquine (PPQ) in Southeast Asia threatens plans to increase the global use of this first-line antimalarial combination. High-level PPQ resistance appears to be med
Externí odkaz:
https://doaj.org/article/5c25b32a34e4401c9b86a31cea46de14
Autor:
Timothy James Russell, Erandi K De Silva, Valerie M Crowley, Kathryn Shaw-Saliba, Namita Dube, Gabrielle Josling, Charisse Flerida A Pasaje, Irene Kouskoumvekaki, Gianni Panagiotou, Jacquin C Niles, Marcelo Jacobs-Lorena, C Denise Okafor, Francisco-Javier Gamo, Manuel Llinás
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010887 (2022)
Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial dru
Externí odkaz:
https://doaj.org/article/32dbbe0804b44aea83886f60da9addc8
Autor:
Jessica Connacher, Gabrielle A. Josling, Lindsey M. Orchard, Janette Reader, Manuel Llinás, Lyn-Marié Birkholtz
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and morphological cha
Externí odkaz:
https://doaj.org/article/553d408fb73241498f3bbf3cac847379
Autor:
Joshua H. Butler, Heather J. Painter, Emily K. Bremers, Priscilla Krai, Manuel Llinás, Maria B. Cassera
Publikováno v:
Molecules, Vol 28, Iss 6, p 2600 (2023)
Cripowellins from Crinum erubescens are known pesticidal and have potent antiplasmodial activity. To gain mechanistic insights to this class of natural products, studies to determine the timing of action of cripowellins within the asexual intraerythr
Externí odkaz:
https://doaj.org/article/6cf11419fab045429664fe7e78ccc009
Autor:
Sachel Mok, Barbara H. Stokes, Nina F. Gnädig, Leila S. Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R. Bottrill, Jaishree Tripathi, Rick M. Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B. Tobin, David A. Fidock
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The emergence and spread of artemisinin resistance has compromised antimalarial efficacy. Here, Mok et al. apply quantitative transcriptomics, proteomics, and metabolomics to provide evidence that K13 mutations alter multiple aspects of the parasite
Externí odkaz:
https://doaj.org/article/bc2f468af6fd4c64bd1c2706fa3f4ce6
Autor:
Janette Reader, Mariëtte E. van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, Andre Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey M. Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Theresa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Here, Reader et al. screen the Medicines for Malaria Venture Pandemic Response Box in parallel against Plasmodiumasexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides. They identify two potent transmission-bl
Externí odkaz:
https://doaj.org/article/469ad5b32c23403795a07ad1d5fdbabe
Autor:
Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or meta
Externí odkaz:
https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f7
Autor:
Lia Chappell, Philipp Ross, Lindsey Orchard, Timothy J. Russell, Thomas D. Otto, Matthew Berriman, Julian C. Rayner, Manuel Llinás
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background Plasmodium parasites undergo several major developmental transitions during their complex lifecycle, which are enabled by precisely ordered gene expression programs. Transcriptomes from the 48-h blood stages of the major human mal
Externí odkaz:
https://doaj.org/article/172e3be00fae4ab4a4c40f83eb55a557