Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Manuel J Del Rey"'
1
Akademický článek
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis
Autor: Alicia Usategui, Cristina Municio, Elena G. Arias-Salgado, María Martín, Beatriz Fernández-Varas, Manuel J. Del Rey, Patricia Carreira, Antonio González, Gabriel Criado, Rosario Perona, José L. Pablos
Publikováno v: Immunity & Ageing, Vol 19, Iss 1, Pp 1-9 (2022)
Abstract Background To investigate the role of cell senescence in systemic sclerosis (SSc), we analyzed telomere shortening (TS) in SSc patients and the effect of targeting DNA damage in the bleomycin model of skin fibrosis. Results Telomere length (
Externí odkaz: https://doaj.org/article/c39d1f7ddcdd4e77af7df6790b4c5c07
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2
Akademický článek
IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms
Autor: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jesús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado, José L. Pablos
Publikováno v: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Introduction The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target
Externí odkaz: https://doaj.org/article/d966f2637fe742f6aedba0c75a9ebd6b
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3
Akademický článek
TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunction
Autor: Manuel J. Del Rey, Carolina Meroño, Cristina Municio, Alicia Usategui, María Mittelbrunn, Inés García-Consuegra, Gabriel Criado, José L. Pablos
Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and functio
Externí odkaz: https://doaj.org/article/1976ea94fa7f478699300552ccb8d024
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4
Akademický článek
Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
Autor: Manuel J. Del Rey, Álvaro Valín, Alicia Usategui, Sandra Ergueta, Eduardo Martín, Cristina Municio, Juan D. Cañete, Francisco J. Blanco, Gabriel Criado, José L. Pablos
Publikováno v: Immunity & Ageing, Vol 16, Iss 1, Pp 1-9 (2019)
Abstract Background Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence in human synovial tissues (ST),
Externí odkaz: https://doaj.org/article/c7efb0a91ee24610af4df5388ee0e113
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5
Akademický článek
Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
Autor: Manuel J. Del Rey, Álvaro Valín, Alicia Usategui, Carmen M. García-Herrero, María Sánchez-Aragó, José M. Cuezva, María Galindo, Beatriz Bravo, Juan D. Cañete, Francisco J. Blanco, Gabriel Criado, José L. Pablos
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The
Externí odkaz: https://doaj.org/article/e4ee554040b04e408dfa0f0ad44bfcfc
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6
Akademický článek
Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk.
Autor: Manuel J Del Rey, Regina Faré, Elena Izquierdo, Alicia Usategui, José L Rodríguez-Fernández, Abel Suárez-Fueyo, Juan D Cañete, José L Pablos
Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99607 (2014)
Synovial fibroblasts (SF) undergo phenotypic changes in rheumatoid arthritis (RA) that contribute to inflammatory joint destruction. This study was undertaken to evaluate the clinical and functional significance of ectopic podoplanin (gp38) expressio
Externí odkaz: https://doaj.org/article/ba51c98777ef494b92b02779dd306599
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7
TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunction
Autor: Carolina Meroño, Manuel J. Del Rey, Cristina Municio, María Mittelbrunn, Inés García-Consuegra, José L. Pablos, Alicia Usategui, Gabriel Criado
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and functio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a5fc2e2a947851f011152e345e422d
http://hdl.handle.net/10261/269484
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8
Il6/Sil6R Regulates Tnfα-Inflammatory Response In Synovial Fibroblasts Through Modulation of Transcriptional and Post-Transcriptional Mechanisms
Autor: Marina Romero, Yolanda Ruano, José L. Pablos, Francisco J. Blanco, Alicia Usategui, Cristina Municio, Alvaro Valin, Gabriel Criado, Jesús Fernández-Felipe, Juan D. Cañete, Manuel J. Del Rey
Publikováno v: BMC Molecular and Cell Biology
RUC. Repositorio da Universidade da Coruña
instname
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-12 (2020)
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)
Introduction The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to IL6/s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ff462129737279ed2447ac4a13bdce
https://doi.org/10.21203/rs.3.rs-32228/v1
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9
Akademický článek
Immature blood vessels in rheumatoid synovium are selectively depleted in response to anti-TNF therapy.
Autor: Elena Izquierdo, Juan D Cañete, Raquel Celis, Begoña Santiago, Alicia Usategui, Raimon Sanmartí, Manuel J Del Rey, José L Pablos
Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8131 (2009)
BACKGROUND:Angiogenesis is considered an important factor in the pathogenesis of Rheumatoid Arthritis (RA) where it has been proposed as a therapeutic target. In other settings, active angiogenesis is characterized by pathologic, immature vessels tha
Externí odkaz: https://doaj.org/article/b564999162dd4472b773635f9eb8cdf5
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10
Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
Autor: María Galindo, José M. Cuezva, Carmen M. García-Herrero, Francisco J. Blanco, Manuel J. Del Rey, Juan D. Cañete, Alicia Usategui, Beatriz Bravo, María Sánchez-Aragó, José L. Pablos, Alvaro Valin, Gabriel Criado
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
RUC. Repositorio da Universidade da Coruña
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
Digital.CSIC. Repositorio Institucional del CSIC
Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The purpose o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29b83d767cff20bced9bbf700ac251c
https://doaj.org/article/e4ee554040b04e408dfa0f0ad44bfcfc
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