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pro vyhledávání: '"Manuel Ingo Günther"'
Peptides and Astroglia Improve the Regenerative Capacity of Alginate Gels in the Injured Spinal Cord
Autor:
Rainer Müller, Thomas Schackel, Manuel Brunner, Norbert Weidner, Radhika Puttagunta, Beatrice Sandner, Prateek Kumar, Shengwen Liu, Manuel Ingo Günther, Armin Blesch
Publikováno v:
Tissue Engineering Part A. 25:522-537
Axonal bridging across a lesion in the injured spinal cord requires a growth substrate and guidance cues. Using alginate hydrogels with capillary channels we show that poly-l-ornithine and laminin can be stably bound and improve cell adhesion and neu
Publikováno v:
Acta Biomaterialia. 27:140-150
Despite recent progress in enhancing axonal growth in the injured spinal cord, the guidance of regenerating axons across an extended lesion site remains a major challenge. To determine whether regenerating axons can be guided in rostrocaudal directio
Publikováno v:
Journal of Neuroscience Methods. 251:143-150
Background Regeneration of axons is one means to restore function after central nervous system and peripheral nervous system injury. Besides increasing the number of regenerating axons, guidance of axons over long distances into and across a lesion s